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SMT3 suppressor of mif two 3 homolog 4

This gene is a member of the SUMO gene family. This family of genes encode small ubiquitin-related modifiers that are attached to proteins and control the target proteins' subcellular localization, stability, or activity. The protein described in this record is located in the cytoplasm and specifically modifies IKBA, leading to negative regulation of NF-kappa-B-dependent transcription of the IL12B gene. A specific polymorphism in this SUMO gene, which leads to the M55V substitution, has been associated with type I diabetes. The RefSeq contains this polymorphism. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: Ubiquitin, Insulin, Smt3, HAD, CTLA-4
Papers on SUMO4
A proteomic study of the regulatory role for STAT-1 in cytokine-induced beta-cell death.
Overbergh et al., Leuven, Belgium. In Proteomics Clin Appl, Oct 2015
Finally, a central role in this STAT-1-regulated mechanism was assigned to small ubiquitin-related modifier 4 (SUMO4).
[Associations of SUMO4 polymorphisms with tacrolimus concentrations in Chinese renal transplant recipients].
Huang et al., In Yao Xue Xue Bao, Feb 2015
The study aims to investigate the associations of SUMO4 polymorphisms with tacrolimus concentrations in Chinese renal transplant recipients.
Genetic polymorphisms of NFκB1 -94 del/ins ATTG, NFκB1A 2758 A>G and SUMO rs237025 G>A in psoriasis.
Al Robaee et al., Saudi Arabia. In Int J Health Sci (qassim), 2015
BACKGROUND: Nuclear factor-κB (NF-κB) and small ubiquitin-like modifier (SUMO4) are key transcription factors involved in the regulation of immune responses and apoptosis.
Association between Genetic Variants and Diabetes Mellitus in Iranian Populations: A Systematic Review of Observational Studies.
Amoli et al., Tehrān, Iran. In J Diabetes Res, 2014
We found significant association between CTLA-4, IL-18, VDR, TAP2, IL-12, and CD4 genes and T1DM, HNFα and MODY, haptoglobin, paraoxonase, leptin, TCF7L2, calreticulin, ERα, PPAR-γ2, CXCL5, calpain-10, IRS-1 and 2, GSTM1, KCNJ11, eNOS, VDR, INSR, ACE, apoA-I, apo E, adiponectin, PTPN1, CETP, AT1R, resistin, MMP-3, BChE K, AT2R, SUMO4, IL-10, VEGF, MTHFR, and GSTM1 with T2DM or its complications.
Association of SUMO4 M55V and -94ins/del gene variants with type-2 diabetes.
Cakmakoglu et al., İstanbul, Turkey. In In Vivo, 2014
In the present study, we aimed to investigate the role of small ubiquitin-like modifier 4 (SUMO4) M55V and nuclear factor kappa B1 (NFKB1)-94del/ins in type-2 diabetes mellitus.
Engineering pre-SUMO4 as efficient substrate of SENP2.
Liao et al., Riverside, United States. In Protein Eng Des Sel, 2014
SUMO4, the latest discovered member in the SUMO family, has been found as a type 1 diabetes susceptibility gene and its maturation is not understood so far.
Inflammatory factor-specific sumoylation regulates NF-κB signalling in glomerular cells from diabetic rats.
Liu et al., Shenyang, China. In Inflamm Res, 2014
We investigated whether small ubiquitin-like modifier 4 (SUMO4) regulates renal NF-κB signalling in diabetic rats.
Sumoylation in neurodegenerative diseases.
Weishaupt et al., Basel, Switzerland. In Cell Mol Life Sci, 2013
Later, it turned out that the homologous mammalian proteins SUMO1 to SUMO4 are reversible protein modifiers that can form isopeptide bonds with lysine residues of respective target proteins (Mahajan et al. in Cell 88:97-107, 2).
Small ubiquitin-like modifier 4 M55V polymorphism is not associated with diabetic nephropathy in Iranian type 2 diabetes patients.
Asadifar et al., Khorramābād, Iran. In Indian J Hum Genet, 2013
INTRODUCTION: We studied the impact of small ubiquitin-like modifier 4 (SUMO4) M55V polymorphism on susceptibility to diabetic nephropathy in Iranian type 2 diabetes patients.
Sumo paralogs: redundancy and divergencies.
Chiocca et al., Milano, Italy. In Front Biosci (schol Ed), 2012
Although sharing a common conjugation pathway, SUMO1, SUMO2/3 and SUMO4 seem to play preferential roles in the cell.
The genetics of Behçet's disease in a Chinese population.
Yang et al., Chongqing, China. In Front Med, 2012
A large number of gene polymorphisms were studied including STAT4, IL23R, CD40, CCR1/CCR3, STAT3, OPN, IL17, JAK2, MCP-1, CTLA4, PD-1, PD-L1, PD-L2, TGRBR3, CCR6, PTPN22, FCRL3, IRF5, SUMO4 and UBAC2.
[Association between SUMO4 polymorphisms and coronary artery disease with and without type 2 diabetes mellitus].
Jin et al., Beijing, China. In Zhonghua Yi Xue Yi Chuan Xue Za Zhi, 2012
OBJECTIVE: To assess the role of small ubiquitin-like modifier 4 (SUMO4) gene polymorphisms (rs237025, rs237024 and rs600739) in the susceptibility to coronary artery disease (CAD) with and without type 2 diabetes mellitus (T2DM) in Chinese Han ethnic population in Beijing.
[Association between SUMO4 polymorphisms and type 2 diabetes mellitus].
Jin et al., Beijing, China. In Yi Chuan, 2012
the association between small ubiquitin-like modifier 4 (SUMO4) gene polymorphisms and type 2 diabetes mellitus
Association of small ubiquitin-like modifier 4 gene polymorphisms with rheumatoid arthritis in a Tunisian population.
Hamzaoui et al., In Clin Exp Rheumatol, 2011
Letter: report SUMO4 polymorphisms associated with protective effect in Tunisian rheumatoid arthritis patients.
No association of the SUMO4 polymorphism M55V variant in type 2 diabetes in Iranian subjects.
Hedayati et al., Tehrān, Iran. In Diabetes Res Clin Pract, 2010
The SUMO4 gene single nucleotide polymorphism variant is not associated with susceptibility of the type 2 diabetes polymorphism.
Association of SUMO4 M55V polymorphism with type 1 diabetes in Chinese children.
Yan et al., Beijing, China. In J Pediatr Endocrinol Metab, 2010
SUMO4 gene M55V variant is associated with the genetic susceptibility of type 1 diabetes mellitus (T1D) in Chinese children.
Association of small ubiquitin-like modifier 4 (SUMO4) polymorphisms in a Tunisian population with Behçet's disease.
Hamzaoui et al., Tunisia. In Clin Exp Rheumatol, 2010
SUMO4 gene polymorphisms may be involved in the development of skin lesions, vascular Behcet's disease, as well as the severity of the disease.
Candidate genes implicated in type 1 diabetes susceptibility.
Aribi, Tlemcen, Algeria. In Curr Diabetes Rev, 2008
Multiplex families studies, using genetic markers allowed the identification of various genes, including HLA, insulin, SUMO-4 and CTLA-4 all being linked with different degrees to disease risk.
A functional variant of SUMO4, a new I kappa B alpha modifier, is associated with type 1 diabetes.
Wang et al., Augusta, United States. In Nat Genet, 2004
we report evidence for an association between T1D and multiple single-nucleotide polymorphisms in 197 kb of genomic DNA in the IDDM5 interval.
A genome-wide search for human type 1 diabetes susceptibility genes.
Palmer et al., Radcliffe, United Kingdom. In Nature, 1994
Linkages to chromosomes 11q (IDDM4) and 6q (IDDM5) were confirmed by replication, and chromosome 18 may encode a fifth disease locus.
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