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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Dec 2016.

Sulfatase 2

SULF2, sulfatase 2, HSulf-2
Heparan sulfate proteoglycans (HSPGs) act as coreceptors for numerous heparin-binding growth factors and cytokines and are involved in cell signaling. Heparan sulfate 6-O-endosulfatases, such as SULF2, selectively remove 6-O-sulfate groups from heparan sulfate. This activity modulates the effects of heparan sulfate by altering binding sites for signaling molecules (Dai et al., 2005 [PubMed 16192265]).[supplied by OMIM, Mar 2008] (from NCBI)
Top mentioned proteins: sulfatase, CAN, V1a, iMpact, HAD
Papers on SULF2
Heparan Sulfate 6-O-EndoSulfatases, Sulf1 and Sulf2, Regulate Glomerular Integrity by Modulating Growth Factor Signaling.
Nagata et al., Tsukuba, Japan. In Am J Physiol Renal Physiol, Feb 2016
We investigated the roles of heparan sulfate 6-O-endosulfatases, Sulf1 and Sulf2, in glomerular homeostasis.
Chemopreventive and hepatoprotective roles of adiponectin (SULF2 inhibitor) in hepatocelluar carcinoma.
Hamdan et al., In Biol Chem, Feb 2016
UNASSIGNED: Sulfatase 2 (SULF2) is an extracellular enzyme that catalyzes the removal of 6-O-sulfate groups from the heparan sulfate (HS).
Sulfatase 2 promotes breast cancer progression through regulating some tumor-related factors.
Gu et al., Shanghai, China. In Oncol Rep, Jan 2016
UNASSIGNED: In previous studies Sulf2 has been evidenced to play an important role in tumor progression through editing sulfate moieties on heparan sulfate proteoglycans (HSPGs) and modulating heparin binding growth factors.
Correlation of the Osteoarthritis Susceptibility Variants That Map to Chromosome 20q13 With an Expression Quantitative Trait Locus Operating on NCOA3 and With Functional Variation at the Polymorphism rs116855380.
Reynard et al., Newcastle upon Tyne, United Kingdom. In Arthritis Rheumatol, Nov 2015
OBJECTIVE: To functionally characterize the osteoarthritis (OA) susceptibility variants that map to a region of high linkage disequilibrium (LD) on chromosome 20q13 marked by the single-nucleotide polymorphism (SNP) rs6094710 and encompassing NCOA3 and SULF2.
Intussusceptive-like angiogenesis in human fetal lung xenografts: Link with bronchopulmonary dysplasia-associated microvascular dysangiogenesis?
Boekelheide et al., Providence, United States. In Exp Lung Res, Nov 2015
qRT-PCR analysis confirmed significant upregulation of SULF2, IGF2, and HMOX1 in graft regions with PFA.
Expression of Sulf1 and Sulf2 in cartilage, bone and endochondral fracture healing.
Dhoot et al., London, United Kingdom. In Histochem Cell Biol, Nov 2015
UNASSIGNED: SULF1/SULF2 enzymes regulate cell signalling that impacts the growth and differentiation of many tissues.
Cellular interaction and cytotoxicity of the iowa mutation of apolipoprotein A-I (ApoA-IIowa) amyloid mediated by sulfate moieties of heparan sulfate.
Sakashita et al., Tokushima, Japan. In J Biol Chem, Nov 2015
We also found that cellular interaction and cytotoxicity of apoA-IIowa amyloid were significantly attenuated in CHO cells that stably expressed the human extracellular endoglucosamine 6-sulfatases HSulf-1 and HSulf-2.
Identification of genes regulating TRAIL-induced apoptosis in rheumatoid arthritis fibroblasts-like synoviocytes.
Morel et al., Montpellier, France. In Genes Immun, Oct 2015
These factors are implicated in different functions, such as the respiratory chain (ND3), the transport of lipids (OSBP2, PLTP), the regulation of signaling linked to extracellular factors (SULF2, GALNT1, SIAE) or the regulation of gene expression (TET2 and LARP6).
Korpershoek et al., Delft, Netherlands. In J Hypertens, Jun 2015
Five genes showed an FDR below 0.01 and were overexpressed in malignant tumours with a ratio higher than 4, including Contactin 4 (CNTN4), Iroquois Homeobox 3 (IRX3), and Sulfatase 2 (SULF2).
Sulf1 and Sulf2 Differentially Modulate Heparan Sulfate Proteoglycan Sulfation during Postnatal Cerebellum Development: Evidence for Neuroprotective and Neurite Outgrowth Promoting Functions.
Dierks et al., Bielefeld, Germany. In Plos One, 2014
INTRODUCTION: Sulf1 and Sulf2 are cell surface sulfatases, which remove specific 6-O-sulfate groups from heparan sulfate (HS) proteoglycans, resulting in modulation of various HS-dependent signaling pathways.
Inhibition of Pediatric Glioblastoma Tumor Growth by the Anti-Cancer Agent OKN-007 in Orthotopic Mouse Xenografts.
Towner et al., Oklahoma City, United States. In Plos One, 2014
Furthermore, in relationship to the PDGFRα pathway, OKN-007 was able to significantly decrease SULF2 (p<0.05) and PDGFR-α (platelet-derived growth factor receptor-α) (p<0.05)
The Role of Heparanase and Sulfatases in the Modification of Heparan Sulfate Proteoglycans within the Tumor Microenvironment and Opportunities for Novel Cancer Therapeutics.
Dredge et al., Brisbane, Australia. In Front Oncol, 2013
As substrates for the key enzymes sulfatases and heparanase, the modification of HSPGs is typically characterized by the degradation of heparan sulfate (HS) chains/sulfation patterns via the endo-6-O-sulfatases (Sulf1 and Sulf2) or by heparanase, an endo-glycosidase that cleaves the HS polymers releasing smaller fragments from HSPG complexes.
SULF2 methylation is prognostic for lung cancer survival and increases sensitivity to topoisomerase-I inhibitors via induction of ISG15.
Belinsky et al., Albuquerque, United States. In Oncogene, 2012
genes and pathways modulated by epigenetic inactivation of SULF2 and the effects on sensitivity to chemotherapy were characterized in lung cancer in vitro and in vivo; silencing SULF2 primarily increased expression of interferon-inducible genes including ISG15
Organ-specific sulfation patterns of heparan sulfate generated by extracellular sulfatases Sulf1 and Sulf2 in mice.
Keino-Masu et al., Tsukuba, Japan. In J Biol Chem, 2012
Sulf1 and Sulf2 differentially contribute to the generation of organ-specific sulfation patterns of heparan sulfate.
Heparan sulfate sulfatase SULF2 regulates PDGFRα signaling and growth in human and mouse malignant glioma.
Werb et al., San Francisco, United States. In J Clin Invest, 2012
Heparan sulfate sulfatase SULF2 regulates PDGFRalpha signaling and growth in human and mouse malignant glioma
Sulf2 gene is alternatively spliced in mammalian developing and tumour tissues with functional implications.
Dhoot et al., London, United Kingdom. In Biochem Biophys Res Commun, 2011
This study demonstrates that unlike normal adult lung with little or no SULF2 expression, this enzyme is expressed at high levels in most lung tumours showing differential cellular distribution of full length and shorter SULF2 variants in such tumours.
SULFs in human neoplasia: implication as progression and prognosis factors.
Klein et al., Montpellier, France. In J Transl Med, 2010
SULF1 and SULF2 are overexpressed in various human cancer types and can be associated to progression and prognosis.
Heparin-degrading sulfatases in hepatocellular carcinoma: roles in pathogenesis and therapy targets.
Roberts et al., Rochester, United States. In Future Oncol, 2008
Two recently identified human heparin-degrading endosulfatases, named sulfatase 1 (SULF1) and sulfatase 2 (SULF2), have been found to be involved in liver carcinogenesis.
The tumor suppressor function of human sulfatase 1 (SULF1) in carcinogenesis.
Roberts et al., Rochester, United States. In J Gastrointest Cancer, 2007
CONCLUSION: Strategies targeting SULF1 or the interaction between SULF1 and the related sulfatase 2 will potentially be important in developing novel cancer therapies.
The heparanome--the enigma of encoding and decoding heparan sulfate sulfation.
Dierks et al., Bielefeld, Germany. In J Biotechnol, 2007
The recent discovery of two sulfatases, Sulf1 and Sulf2, with the unique ability to edit sulfation patterns at the cell surface, has opened up a new dimension as to how we understand the regulation of HS sulfation patterning and pattern-dependent cell signaling events.
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