gopubmed logo
find other proteinsAll proteins
GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Dec 2016.

Recombination signal binding protein for immunoglobulin kappa J region-like

In mouse, recombining binding protein L (RBP-L) is a transcription factor that binds to DNA sequences almost identical to that bound by the Notch receptor signalling pathway transcription factor RBP-J. However, unlike RBP-J, RBP-L does not interact with Notch receptors. RBP-L has been shown to activate transcription in concert with Epstein-Barr virus nuclear antigen-2 (EBNA2). The protein encoded by this gene is similar in sequence to the mouse RPB-L protein and Drosophila suppressor of hairless protein. [provided by RefSeq, Jul 2008] (from NCBI)
Sponsored links
Top mentioned proteins: RBP, Ptf1a, CBF1, ACID, FATE
Papers on Suhl
The nuclear hormone receptor family member NR5A2 controls aspects of multipotent progenitor cell formation and acinar differentiation during pancreatic organogenesis.
MacDonald et al., Dallas, United States. In Development, 2014
NR5A2 controls these developmental processes directly as well as through regulatory interactions with other pancreatic transcriptional regulators, including PTF1A, MYC, GATA4, FOXA2, RBPJL and MIST1 (BHLHA15).
The human pancreas proteome defined by transcriptomics and antibody-based profiling.
Lindskog et al., Uppsala, Sweden. In Plos One, 2013
Among the elevated expression profiles, several previously not described proteins were identified, both in endocrine cells (CFC1, FAM159B, RBPJL and RGS9) and exocrine glandular cells (AQP12A, DPEP1, GATM and ERP27).
Gata6 is required for complete acinar differentiation and maintenance of the exocrine pancreas in adult mice.
Real et al., Madrid, Spain. In Gut, 2013
Gata6 regulates directly the promoter of genes coding for digestive enzymes and the transcription factors Rbpjl and Mist1.
ICAT is a novel Ptf1a interactor that regulates pancreatic acinar differentiation and displays altered expression in tumours.
Real et al., Madrid, Spain. In Biochem J, 2013
In the adult pancreas, PTF1 contains two pancreas-restricted transcription factors: Ptf1a and Rbpjl.
Directed pancreatic acinar differentiation of mouse embryonic stem cells via embryonic signalling molecules and exocrine transcription factors.
Skoudy et al., Barcelona, Spain. In Plos One, 2012
The newly differentiated cells were able to release α-amylase and this feature was greatly improved by lentiviral-mediated expression of Rbpjl and Ptf1a, two transcription factors involved in the maximal production of digestive enzymes.
[A town-physician in the 18th century: Johann Friedrich Glaser].
Schilling, Berlin, Germany. In Wurzbg Medizinhist Mitt, 2010
Johann Friedrich Glaser rose from an executioner's family to the position of a town physician in Suhl.
Replacement of Rbpj with Rbpjl in the PTF1 complex controls the final maturation of pancreatic acinar cells.
MacDonald et al., Dallas, United States. In Gastroenterology, 2010
Replacement of Rbpj by Rbpjl in the PTF1 complex drives acinar differentiation by maximizing secretory protein synthesis.
Activated Notch1 target genes during embryonic cell differentiation depend on the cellular context and include lineage determinants and inhibitors.
Just et al., Kiel, Germany. In Plos One, 2009
Notch1/RBP-J signaling induces expression of key transcriptional regulators involved in cell lineage determination in the absence of protein synthesis
p/CAF modulates the activity of the transcription factor p48/Ptf1a involved in pancreatic acinar differentiation.
Real et al., Barcelona, Spain. In Biochem J, 2009
High-level expression of exocrine digestive enzymes, a hallmark of mature acinar cells, depends largely on the trimeric complex PTF1, formed by p48, RBP-L (recombination signal-binding protein 1-like) and a class A bHLH protein.
Transcriptional autoregulation controls pancreatic Ptf1a expression during development and adulthood.
Macdonald et al., Dallas, United States. In Mol Cell Biol, 2008
The enhancer contains two evolutionarily conserved binding sites for the active form of PTF1a, a trimeric complex composed of PTF1a, one of the common bHLH E proteins, and either RBPJ or RBPJL.
Early pancreatic development requires the vertebrate Suppressor of Hairless (RBPJ) in the PTF1 bHLH complex.
MacDonald et al., Dallas, United States. In Genes Dev, 2007
During pancreatic acinar development, Rbpjl replaces Rbpj in the PTF1 complex residing on active acinar specific promoters.
PTF1 is an organ-specific and Notch-independent basic helix-loop-helix complex containing the mammalian Suppressor of Hairless (RBP-J) or its paralogue, RBP-L.
MacDonald et al., Dallas, United States. In Mol Cell Biol, 2006
RBPJL is the third subunit of an unusual bHLH factor complex that binds and activates pancreatic acinar specific genes
Identification and characterization of human HESL, rat Hesl and rainbow trout hesl genes in silico.
Katoh et al., Narashino, Japan. In Int J Mol Med, 2004
Activation of Notch signaling pathway leads to nuclear translocation of Notch intracellular domain (NIC), and transcriptional activation of target genes through the interaction between CSL proteins (RBPSUH or RBPSUHL) and NIC.
New molecular defects in the gamma subdomain of fibrinogen D-domain in four cases of (hypo)dysfibrinogenemia: fibrinogen variants Hannover VI, Homburg VII, Stuttgart and Suhl.
Barthels et al., Jena, Germany. In Thromb Haemost, 2003
Four new molecular abnormalities in the gamma subdomain of the D domain elucidated in three unrelated thrombophilic patients and in one asymptomatic case of hypofibrinogenemia are reported: fibrinogen Suhl, gamma 326, Cys-->Tyr, fibrinogen Hannover VI, gamma 336 Met-->Ile, fibrinogen Stuttgart, gamma 345, Asn-->Asp and fibrinogen Homburg VII, gamma 354,Tyr-->Cys.
Characterization of the mouse matrilin-4 gene: a 5' antiparallel overlap with the gene encoding the transcription factor RBP-l.
Paulsson et al., Köln, Germany. In Genomics, 2001
Matn4 divergently overlapped 5' with the gene encoding RBP-L (for recombining binding protein suppressor of hairless-like; Rbpsuhl), a transcription factor with homology to RBP-JK.
The N- and C-terminal regions of RBP-J interact with the ankyrin repeats of Notch1 RAMIC to activate transcription.
Honjo et al., Kyoto, Japan. In Nucleic Acids Res, 2001
The studies using chimeric molecules between RBP-J and its homolog RBP-L showed that the N- and C-terminal regions of RBP-J conferred the IC- as well as RAMIC-induced transactivation potential on RBP-L, which binds to the same DNA sequence as RBP-J but fails to interact with RAMIC.
share on facebooktweetadd +1mail to friends