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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Dec 2016.

Syntaxin 1A

stx1, Syntaxin 1, syntaxin 1A, HPC1
This gene encodes a member of the syntaxin superfamily. Syntaxins are nervous system-specific proteins implicated in the docking of synaptic vesicles with the presynaptic plasma membrane. Syntaxins possess a single C-terminal transmembrane domain, a SNARE [Soluble NSF (N-ethylmaleimide-sensitive fusion protein)-Attachment protein REceptor] domain (known as H3), and an N-terminal regulatory domain (Habc). Syntaxins bind synaptotagmin in a calcium-dependent fashion and interact with voltage dependent calcium and potassium channels via the C-terminal H3 domain. This gene product is a key molecule in ion channel regulation and synaptic exocytosis. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Sep 2009] (from NCBI)
Top mentioned proteins: CAN, Stx, SNAP-25, HAD, POLYMERASE
Papers using stx1 antibodies
Membrane microdomain switching: a regulatory mechanism of amyloid precursor protein processing
Nukina Nobuyuki et al., In The Journal of Cell Biology, 2001
... and Invitrogen); anti-X11, anti-p35, and anti-ADAM17 (Santa Cruz Biotechnology, Inc.); rat anti-GFP (RQ2) and mouse anti–syntaxin 1 (HPC-1; MBL International); rabbit anti-Munc18 (Affinity ...
SAM: significance analysis of microarrays
Brooks James D et al., In Genome Biology, 2000
... Anderson Cancer Center and were cultured in defined BRFF-HPC1 media (Biological Research Faculty & Facility, Ijamsville, MD) and maintained on poly-lysine-coated tissue culture plates (Becton Dickinson Labware, Franklin Lakes, NJ) ...
Metabolic bone disease and clinically related disorders.
Bernhard Eric J., In PLoS ONE, 1997
... in BRFF-HPC1 medium (Biological Research Faculty and Facility, Athena Environmental Services, Baltimore, MD, USA) supplemented with 20% fetal bovine serum (Life Technologies, Inc., Gaithersburg, MD, USA), ...
Papers on stx1
A Novel Syntaxin 11 Gene (STX11) Mutation c.650T>C, p.Leu217Pro, in a Korean Child With Familial Hemophagocytic Lymphohistiocytosis.
Kim et al., Astana, Kazakhstan. In Ann Lab Med, Mar 2016
A cumulative study of such novel mutations and their effects on specific protein interactions may deepen the understanding of how abnormal STX1 expression results in deficient cytotoxic function.
Multiplex Quantitative PCR Assays for the Detection and Quantification of the Six Major Non-O157 Escherichia coli Serogroups in Cattle Feces.
Bai et al., Manhattan, United States. In J Food Prot, Jan 2016
The objectives of our study were (i) to develop and validate two multiplex quantitative PCR (mqPCR) assays, targeting O-antigen genes of O26, O103, and O111 (mqPCR-1) and O45, O121, and O145 (mqPCR-2); (ii) to utilize the two assays, together with a previously developed four-plex qPCR assay (mqPCR-3) targeting the O157 antigen and three virulence genes (stx1, stx2, and eae), to quantify seven serogroups and three virulence genes in cattle feces; and (iii) to compare the three mqPCR assays to a 10-plex conventional PCR (cPCR) targeting seven serogroups and three virulence genes and culture methods to detect seven E. coli serogroups in cattle feces.
Shiga toxigenic and enteropathogenic Escherichia coli in water and fish from pay-to-fish ponds.
Amaral et al., Jaboticabal, Brazil. In Lett Appl Microbiol, Jan 2016
Of the 115 E. coli isolates from fish or water, five (4.34%) contained eae and stx2 genes, one had only the eae gene and two had the stx1 gene.
Differential expression of neurogenes among breast cancer subtypes identifies high risk patients.
Gascón et al., Barcelona, Spain. In Oncotarget, Jan 2016
Histamine receptor1 (HRH1), neuropilin2 (NRP2), ephrin-B1 (EFNB1), neural growth factor receptor (NGFR) and amyloid precursor protein (APP) were differentially overexpressed in basal and HER2-enriched tumor samples and syntaxin 1A (STX1A) was overexpressed in HER2-enriched and luminal B tumors.
Isolation of atypical enteropathogenic and shiga toxin encoding Escherichia coli strains from poultry in Tehran, Iran.
Zali et al., Tehrān, Iran. In Gastroenterol Hepatol Bed Bench, Dec 2015
PATIENTS AND METHODS: A total of 500 cloacal swab samples from broilers of five different poultry houses (A-E) were collected to investigate the presence of stx1, stx2, hly, eae, and bfp virulence genes among the E. coli isolates by polymerase chain reaction.
Distribution of Shiga toxin genes subtypes in B1 phylotypes of Escherichia coli isolated from calves suffering from diarrhea in Tehran suburb using DNA oligonucleotide arrays.
Salimi-Bejestani et al., Semnān, Iran. In Iran J Microbiol, Aug 2015
Of these isolates, 20 contained stx1a and stx1b and one harbored all mentioned variants of stx genes except stx2b2 .
Syntaxin 1A mediates isoflurane but not hypoxia preconditioning-induced alleviation of hypoxia-reoxygenation injury in rat cardiomyocytes.
Shi et al., Shanghai, China. In Am J Transl Res, 2014
We herein investigated the roles of syntaxin 1A (Stx-1A) in cardiomyocyte protection induced by HPC and Iso-PC.
Identifying and quantitating conformational exchange in membrane proteins using site-directed spin labeling.
Cafiso, Charlottesville, United States. In Acc Chem Res, 2014
Conformational exchange has also been examined in systems such as the plasma membrane SNARE protein, syntaxin 1A, where dynamics are controlled by regulatory proteins such as munc18.
T-type channel-mediated neurotransmitter release.
Vandael et al., Torino, Italy. In Pflugers Arch, 2014
The intriguing issue is that, despite not expressing a consensus "synprint" site, Cav3.2 channels do interact with syntaxin 1A and SNAP-25 and, thus, may form nanodomains with secretory vesicles that can be regulated at low voltages.
Exocytosis and synaptic vesicle function.
Shin, Galveston, United States. In Compr Physiol, 2014
In synapses of the central nervous system, synaptobrevin 2, a major vesicular SNARE protein, forms a ternary SNARE complex with the plasma membrane SNARE proteins, syntaxin 1 and SNAP25.
[Hereditary prostate cancer].
Haus et al., Laizhou, China. In Postepy Hig Med Dosw (online), 2013
Through linkage analysis, numerous prostate cancer susceptibility chromosomal loci have been identified, including: HPC1 (1q24-25), PCaP (1q42.2-43),
The voltage-gated calcium channel functions as the molecular switch of synaptic transmission.
Atlas, Jerusalem, Israel. In Annu Rev Biochem, 2012
This review highlights the molecular aspects of an intramembrane signaling mechanism in which a signal is propagated from the channel transmembrane (TM) domain to the TM domain of syntaxin 1A to trigger transmitter release.
Nesca, a novel neuronal adapter protein, links the molecular motor kinesin with the pre-synaptic membrane protein, syntaxin-1, in hippocampal neurons.
Meakin et al., London, Canada. In J Neurochem, 2012
Nesca directly binds KIF5B, kinesin light-chain and syntaxin-1
The voltage-dependent potassium channel subunit Kv2.1 regulates insulin secretion from rodent and human islets independently of its electrical function.
Macdonald et al., Edmonton, Canada. In Diabetologia, 2012
Direct interaction between syntaxin 1A and the Kv2.1 C-terminus is required for efficient insulin exocytosis and glucose-stimulated insulin secretion.
Proteomic analysis identifies dysfunction in cellular transport, energy, and protein metabolism in different brain regions of atypical frontotemporal lobar degeneration.
Bahn et al., Cambridge, United Kingdom. In J Proteome Res, 2012
A protein encoded by this locus was found to be differentially expressed in postmortem brains from patients with atypical frontotemporal lobar degeneration.
Association analysis of STX1A gene variants in common forms of migraine.
Collier et al., London, United Kingdom. In Cephalalgia, 2012
Our results provide support for the hypothesis that STX1A represents a susceptibility gene for migraine
The Legionella pneumophila effector DrrA is sufficient to stimulate SNARE-dependent membrane fusion.
Roy et al., New Haven, United States. In Cell Host Microbe, 2012
DrrA activation of the Rab1 GTPase on plasma membrane-derived organelles stimulated the tethering of endoplasmic reticulum-derived vesicles, resulting in vesicle fusion through the pairing of Sec22b with the plasma membrane syntaxin proteins.
Helical extension of the neuronal SNARE complex into the membrane.
Jahn et al., Göttingen, Germany. In Nature, 2009
Here, we report the X-ray structure of the neuronal SNARE complex, consisting of rat syntaxin 1A, SNAP-25 and synaptobrevin 2, with the carboxy-terminal linkers and transmembrane regions at 3.4 A resolution.
Anatomy and dynamics of a supramolecular membrane protein cluster.
Lang et al., Göttingen, Germany. In Science, 2007
With syntaxin 1 as an example, we applied a combination of far-field optical nanoscopy, biochemistry, fluorescence recovery after photobleaching (FRAP) analysis, and simulations to show that clustering can be explained by self-organization based on simple physical principles.
N- to C-terminal SNARE complex assembly promotes rapid membrane fusion.
Fasshauer et al., Göttingen, Germany. In Science, 2006
Assembly of the soluble N-ethylmaleimide-sensitive factor attachment protein receptors (SNAREs) syntaxin 1, SNAP-25, and synaptobrevin 2 is thought to be the driving force for the exocytosis of synaptic vesicles.
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