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ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 2

Stx, ST8Sia II
The protein encoded by this gene is a type II membrane protein that is thought to catalyze the transfer of sialic acid from CMP-sialic acid to N-linked oligosaccharides and glycoproteins. The encoded protein may be found in the Golgi apparatus and may be involved in the production of polysialic acid, a modulator of the adhesive properties of neural cell adhesion molecule (NCAM1). This protein is a member of glycosyltransferase family 29. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: stx1, CAN, ACID, HAD, CD56
Papers on Stx
Subtilase contributes to the cytotoxicity of a Shiga toxin-producing Escherichia coli strain encoding three different toxins.
Schmidt et al., Stuttgart, Germany. In Int J Food Microbiol, Feb 2016
Food-borne Shiga toxin-producing Escherichia coli (STEC) O113:H21 strain TS18/08, that has previously been isolated from mixed minced meat, harbors the Shiga toxin (Stx) encoding allele stx2a, the plasmid-located subtilase cytotoxin encoding allele subAB1 and the cytolethal distending toxin type V encoding gene cdt-V.
The Antibiotic Polymyxin B Impairs the Interactions between Shiga Toxins and Human Neutrophils.
Brigotti et al., Bologna, Italy. In J Immunol, Jan 2016
UNASSIGNED: Hemolytic uremic syndrome (HUS) is the life-threatenig sequela of intestinal infections by Shiga toxin (Stx)-producing Escherichia coli (STEC) in children.
Shiga Toxins Trigger the Secretion of Lysyl-tRNA Synthetase to Enhance Proinflammatory Responses.
Kim et al., Taejŏn, South Korea. In J Microbiol Biotechnol, Jan 2016
Although numerous studies report proinflammatory responses to Stx type 1 (Stx1) or Stx type 2 (Stx2) both in vivo and in vitro, none have examined dynamic immune regulation involving cytokines and/or unknown inflammatory mediators during intoxication.
Heterogeneity in phage induction enables the survival of the lysogenic population.
Muniesa et al., Barcelona, Spain. In Environ Microbiol, Jan 2016
Using Escherichia coli lysogens for Shiga toxin (Stx) phages as model, we demonstrate how lysogenic bacterial populations circumvent extinction after phage induction.
Quantitative Detection of Shiga Toxins Directly from Stool Specimens of Patients Associated with an Outbreak of Enterohemorrhagic Escherichia coli in Japan--Quantitative Shiga toxin detection from stool during EHEC outbreak.
Kurazono et al., Obihiro, Japan. In Toxins (basel), Oct 2015
Detection of Shiga toxins (Stx) is important for accurate diagnosis of Enterohemorrhagic Escherichia coli infection.
Syntaxin 1A mediates isoflurane but not hypoxia preconditioning-induced alleviation of hypoxia-reoxygenation injury in rat cardiomyocytes.
Shi et al., Shanghai, China. In Am J Transl Res, 2014
We herein investigated the roles of syntaxin 1A (Stx-1A) in cardiomyocyte protection induced by HPC and Iso-PC.
3D structural conformation and functional domains of polysialyltransferase ST8Sia IV required for polysialylation of neural cell adhesion molecules.
Troy et al., Nanning, China. In Protein Pept Lett, 2014
Synthesis of α2,8-polysialic acid (polySia) glycans are catalyzed by two highly homologous mammalian polysialyltransferases (polySTs), ST8Sia II (STX) and ST8Sia IV (PST), which are two members of the ST8Sia gene family of sialytransferases.
Mass Spectrometry-Based Method of Detecting and Distinguishing Type 1 and Type 2 Shiga-Like Toxins in Human Serum.
He et al., Albany, United States. In Toxins (basel), 2014
We determined that this approach can be used to detect, quantify and distinguish among the known Shiga toxins (Stx) and Shiga-like toxins (Stx1 and Stx2) in the low attomole range (per injection) in complex media, including human serum.
Mapping of genetic loci that modulate differential colonization by Escherichia coli O157:H7 TUV86-2 in advanced recombinant inbred BXD mice.
Melton-Celsa et al., Bethesda, United States. In Bmc Genomics, 2014
BACKGROUND: Shiga toxin (Stx)-producing E. coli (STEC) are responsible for foodborne outbreaks that can result in severe human disease.
A Rapid and Sensitive Method to Measure the Functional Activity of Shiga Toxins in Human Serum.
Brigotti et al., Bologna, Italy. In Toxins (basel), 2014
Shiga toxins (Stx) have a definite role in the development of hemolytic uremic syndrome in children with hemorrhagic colitis caused by pathogenic Stx-producing Escherichia coli (STEC) strains.
New Therapeutic Developments against Shiga Toxin-Producing Escherichia coli.
O'Brien et al., In Microbiol Spectr, 2014
Shiga toxin (Stx)-producing Escherichia coli (STEC) is an etiologic agent of bloody diarrhea.
Shiga Toxin-Producing Escherichia coli (STEC) in Fresh Produce--A Food Safety Dilemma.
Feng, In Microbiol Spectr, 2014
The presence of STEC in produce is easily detected by PCR for the Shiga toxin (Stx) gene, stx, but this is insufficient for risk analysis.
Role of complement in enterohemorrhagic Escherichia coli-Induced hemolytic uremic syndrome.
Würzner et al., Innsbruck, Austria. In Semin Thromb Hemost, 2014
Hemolytic uremic syndrome (HUS), the most common cause of acute renal failure in childhood, is mainly caused by infection with Shiga toxin (Stx)-producing enterohemorrhagic Escherichia coli (EHEC).
Shiga Toxin (Stx) Classification, Structure, and Function.
Melton-Celsa, Bethesda, United States. In Microbiol Spectr, 2013
Shiga toxin (Stx) is one of the most potent bacterial toxins known.
Expression and localization of neural cell adhesion molecule and polysialic acid during chick corneal development.
Conrad et al., Manhattan, United States. In Invest Ophthalmol Vis Sci, 2012
NCAM and polySia are expressed and developmentally regulated in chick corneas. Both membrane-associated and soluble NCAM isoforms are expressed in chick corneas.
Manganese blocks intracellular trafficking of Shiga toxin and protects against Shiga toxicosis.
Linstedt et al., Pittsburgh, United States. In Science, 2012
Infections with Shiga toxin (STx)-producing bacteria cause more than a million deaths each year and have no definitive treatment.
Regulatory roles of ganglioside GQ1b in neuronal cell differentiation of mouse embryonic stem cells.
Choo et al., Iksan, South Korea. In Bmb Rep, 2011
results suggest that the ST8Sia5 gene increases ganglioside GQ1b and improves neuronal differentiation via the ERK1/2 MAP kinase pathway
Identification of sialyltransferase 8B as a generalized susceptibility gene for psychotic and mood disorders on chromosome 15q25-26.
Fullerton et al., Sydney, Australia. In Plos One, 2011
that variation the ST8SIA2 gene is associated with increased risk to mental illness
Chronic stress induces changes in the structure of interneurons and in the expression of molecules related to neuronal structural plasticity and inhibitory neurotransmission in the amygdala of adult mice.
Nacher et al., Valencia, Spain. In Exp Neurol, 2011
At the mRNA level, the expression of GAD67 and of St8SiaII was significantly reduced by chronic stress in the amygdala of adult mice.
Sensory experience differentially modulates the mRNA expression of the polysialyltransferases ST8SiaII and ST8SiaIV in postnatal mouse visual cortex.
Di Cristo et al., Montréal, Canada. In Plos One, 2010
While both ST8SiaII and ST8SiaIV mRNA levels decrease around the time of eye opening in mouse visual cortex, only ST8SiaII mRNA level reduction is regulated by sensory experience
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