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Matrix metallopeptidase 11

stromelysin-3, Matrix Metalloproteinase 11, ST3, SL3, MMP-11
Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Most MMP's are secreted as inactive proproteins which are activated when cleaved by extracellular proteinases. However, the enzyme encoded by this gene is activated intracellularly by furin within the constitutive secretory pathway. Also in contrast to other MMP's, this enzyme cleaves alpha 1-proteinase inhibitor but weakly degrades structural proteins of the extracellular matrix. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: CAN, HAD, ST1, MMP-9, ACID
Papers on stromelysin-3
Compliance of ENT emergency surgery with the Royal College of Surgeons standards.
Persaud et al., Dubai, United Arab Emirates. In Ann R Coll Surg Engl, Jan 2016
The standards with the highest compliance included 24-hour availability of blood transfusion and haematology opinion for patients with epistaxis, availability of a consultant or ST3/equivalent for immediate discussion of severe post-tonsillectomy bleeding, 24-hour access to blood transfusion for arrest of haemorrhage and immediate theatre access for arrest of haemorrhage.
Malley et al., Seoul, South Korea. In Clin Vaccine Immunol, Jan 2016
In vitro released CPS concentrations per 10(7) CFU of ST3 and 37 strains were significantly higher than for ST 1, 4, 6B, and 14 strains.
Chronic spontaneous urticaria and internal parasites - a systematic review.
Maurer et al., Moscow, Russia. In Allergy, Jan 2016
Patients with chronic urticaria more frequently had seropositivity of fasciolosis, Anisakis simplex sensitization and presence of Blastocystis hominis allele 34 (ST3) as compared with control subjects.
Molecular Characterization and Subtyping of Blastocystis Species in Irritable Bowel Syndrome Patients from North India.
Chaudhry et al., New Delhi, India. In Plos One, Dec 2015
Isolates of Blastocystis sp.were subtyped using Sequence Tagged Site and representative samples were sequenced at SSUrRNA locus.A total of sixty five isolates of Blastocystis sp. were identified [IBS (n = 50); Controls (n = 15)] of which 91% belonged to ST3 and 9% belonged to ST1.
Effect of oral administration of Kudoa septempunctata genotype ST3 in adult BALB/c mice.
Shin et al., Cheju, South Korea. In Parasite, 2014
To investigate the effect of K. septempunctata spores in mammals, adult BALB/c mice were fed with spores of K. septempunctata genotype ST3 (1.35 × 10(5) to 1.35 × 10(8) spores/mouse).
Significance of MMP11 and P14(ARF) expressions in clinical outcomes of patients with laryngeal cancer.
Huang et al., Beijing, China. In Int J Clin Exp Med, 2014
BACKGROUND: To evaluate the association of MMP11 and P14(ARF) expression in laryngeal squamous cell carcinoma (LSCC) with clinical pathological characteristics and survival.
Inflammation-related factors predicting prognosis of gastric cancer.
Cao et al., Shanghai, China. In World J Gastroenterol, 2014
Increased serum levels of matrix metalloproteinases (MMP)-3, MMP-7, and MMP-11 and increased levels of MMP-9, MMP-12, and MMP-21 in tumors are consistently associated with poor survival of GC.
Effect of the expression of matrix metalloproteases and their tissue inhibitors on survival of patients with resectable colorectal cancer.
Vizoso et al., Gijón, Spain. In Dig Dis Sci, 2012
expression by fibroblasts associated with poor prognosis in colorectal cancer
Histone deacetylase inhibitors upregulate MMP11 gene expression through Sp1/Smad complexes in human colon adenocarcinoma cells.
Lizarbe et al., Madrid, Spain. In Biochim Biophys Acta, 2012
Results describe MMP-11 expression in human epithelial colon adenocarcinoma cell lines (Caco-2, HT-29 and BCS-TC2).
Eight-signature classifier for prediction of nasopharyngeal [corrected] carcinoma survival.
Shao et al., Guangzhou, China. In J Clin Oncol, 2012
RESULTS: The NPC-SVM classifier integrated patient sex and the protein expression level of seven genes, including Epstein-Barr virus latency membrane protein 1, CD147, caveolin-1, phospho-P70S6 kinase, matrix metalloproteinase 11, survivin, and secreted protein acidic and rich in cysteine.
Matrix metalloproteinase-11 overexpressed in lobular carcinoma cells of the breast promotes anoikis resistance.
Furihata et al., Kōchi, Japan. In Virchows Arch, 2011
MMP-11 is overexpressed in many lobular carcinoma cells, and it may play role in lobular carcinogenesis through increasing resistance to anoikis.
New evidence for a critical role of elastin in calcification of native heart valves: immunohistochemical and ultrastructural study with literature review.
Donato et al., Cosenza, Italy. In Histopathology, 2011
MMP-11 was not detected in the diseased valves.
Gastric cancer: basic aspects.
Ristimäki et al., Porto, Portugal. In Helicobacter, 2011
Several genes have been newly associated with gastric carcinogenesis, both through oncogenic activation (GSK3β, CD133, DSC2, P-Cadherin, CDH17, CD168, CD44, metalloproteinases MMP7 and MMP11, and a subset of miRNAs) and through tumor suppressor gene inactivation mechanisms (TFF1, PDX1, BCL2L10, XRCC, psiTPTE-HERV, HAI-2, GRIK2, and RUNX3).
Amphibian organ remodeling during metamorphosis: insight into thyroid hormone-induced apoptosis.
Ishizuya-Oka, Kawasaki, Japan. In Dev Growth Differ, 2011
Especially, stromelysin-3, a matrix metalloproteinase, has been shown to alter cell-ECM interactions by cleaving a laminin receptor and induce apoptosis in the larval intestinal epithelium.
Co-expression of metalloproteinases 11 and 12 in cervical scrapes cells from cervical precursor lesions.
Salcedo et al., In Int J Clin Exp Pathol, 2010
Report MMP11/12 expression in cervical scrapes cells from cervical precursor lesions.
Results in treatment of early breast cancers and the level of selected metalloproteinases.
Dziadek et al., Kraków, Poland. In Neuro Endocrinol Lett, 2010
Between two of the tested metalloproteinases (MMP-2 and MMP-11) only MMP-2 appears to have prognostic significance in early forms of breast cancer, and its strong expression is associated with shorter survival.
Isotopic labeling of terminal amines in complex samples identifies protein N-termini and protease cleavage products.
Overall et al., Vancouver, Canada. In Nat Biotechnol, 2010
We further demonstrate the potential of our strategy to link proteases with defined biological pathways in complex samples by analyzing mouse inflammatory bronchoalveolar fluid and showing that expression of the poorly defined breast cancer protease MMP-11 in MCF-7 human breast cancer cells cleaves both endoplasmin and the immunomodulator and apoptosis inducer galectin-1.
Expression and prognostic significance of metalloproteinases and their tissue inhibitors in patients with small-cell lung cancer.
Shepherd et al., Toronto, Canada. In J Clin Oncol, 1999
Positive IHC staining was evident for MMP-1 and -9 in 60% to 70% of tumor cells, and for MMP-11, -13, and -14 and TIMP-2 and -3 in 70% to 100% of tumor cells.
Structure of the HIV-1 nucleocapsid protein bound to the SL3 psi-RNA recognition element.
Summers et al., Baltimore, United States. In Science, 1998
The three-dimensional structure of the human immunodeficiency virus-type 1 (HIV-1) nucleocapsid protein (NC) bound to the SL3 stem-loop recognition element of the genomic Psi RNA packaging signal has been determined by heteronuclear magnetic resonance spectroscopy.
Furin-dependent intracellular activation of the human stromelysin-3 zymogen.
Weiss et al., Ann Arbor, United States. In Nature, 1995
Human stromelysin-3, a new member of the matrix metalloproteinase family, is expressed in tissues undergoing the active remodelling associated with embryonic development, wound healing and tumour invasion.
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