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Steroidogenic acute regulatory protein

Steroidogenic Acute Regulatory Protein, Steroidogenic Acute Regulatory, StarD1, STA-R
The protein encoded by this gene plays a key role in the acute regulation of steroid hormone synthesis by enhancing the conversion of cholesterol into pregnenolone. This protein permits the cleavage of cholesterol into pregnenolone by mediating the transport of cholesterol from the outer mitochondrial membrane to the inner mitochondrial membrane. Mutations in this gene are a cause of congenital lipoid adrenal hyperplasia (CLAH), also called lipoid CAH. A pseudogene of this gene is located on chromosome 13. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: CAN, P450scc, ACID, Thromboplastin, InR
Papers on Steroidogenic Acute Regulatory Protein
High-yield soluble expression, purification and characterization of human steroidogenic acute regulatory protein (StAR) fused to a cleavable Maltose-Binding Protein (MBP).
Levitsky et al., Moscow, Russia. In Protein Expr Purif, Mar 2016
Steroidogenic acute regulatory protein (StAR) is responsible for the rapid delivery of cholesterol to mitochondria where the lipid serves as a source for steroid hormones biosynthesis in adrenals and gonads.
Effects of fluoride and aluminum on expressions of StAR and P450scc of related steroidogenesis in guinea pigs' testis.
Wang et al., China. In Chemosphere, Feb 2016
This study investigated the effects of fluoride (NaF) or/and aluminum (AlCl3) on serum testosterone level, gene and protein expression levels of Steroidogenic Acute Regulatory Protein (StAR) and Cytochrome P450 cholesterol side chain cleavage enzyme (P450scc) in the testes of guinea pigs.
Measuring dabigatran with the dilute Russell viper venom confirm assay in an anticoagulation clinic population.
Fritsma et al., Birmingham, United States. In Blood Coagul Fibrinolysis, Jan 2016
We obtained dabigatran calibrators and controls from Biophen, and performed the coagulation assays using a Stago STA-R Evolution coagulometer.
Impairment of Macrophage Cholesterol Efflux by Cholesterol Hydroperoxide Trafficking: Implications for Atherogenesis Under Oxidative Stress.
Girotti et al., Kraków, Poland. In Arterioscler Thromb Vasc Biol, Oct 2015
We tested the novel hypothesis that under oxidative stress conditions, steroidogenic acute regulatory (StAR) family proteins not only deliver cholesterol to/into mitochondria of vascular macrophages, but also 7-OOH, which induces peroxidative damage that impairs early stage reverse cholesterol transport.
[Commutability of reference materials for coagulation factor VIII and factor IX activity on three measurement systems].
Peng et al., Beijing, China. In Zhonghua Yi Xue Za Zhi, Oct 2015
Clinical samples with different levels of FVIII and FIX which covered over the clinical analytical range, five lots of homemade reference materials (F20140601-F20140605) and a coagulation reference material (SSCLOT4) provided by NIBSC were detected for FVIII and FIX activity on three popular measurement systems in China, which including Stago STA-R Evolution, IL ACL TOP700 and Sysmex CA7000 automatic coagulation analyzers using supplementary reagents.
Agreement between Coaguchek XS and STA-R Evolution (Hepato Quick) INR results depends on the level of INR.
Kruip et al., Rotterdam, Netherlands. In Thromb Res, Sep 2015
Therefore we investigated the analytical and clinical agreement between POC INR results of the Coaguchek XS and laboratory INR results of the STA-R Evolution.
Evaluation of point-of-care testing in critically unwell patients: comparison with clinical laboratory analysers and applicability to patients with Ebolavirus infection.
Chen et al., Westmead, Australia. In Pathology, Aug 2015
Measurements obtained for haematology, coagulation, biochemistry and arterial blood gas parameters using POC devices were compared against clinical laboratory analysers (XE-5000, STA-R Evolution, Dimension Vista 1500 and ABL800 FLEX).
Comparison of the INR Values Measured by CoaguChek XS Coagulometer and Conventional Laboratory Methods in Patients on VKA Therapy.
Özkan et al., İstanbul, Turkey. In Clin Appl Thromb Hemost, Aug 2015
OBJECTIVE: To compare the INR results obtained by a portable coagulometer (CoaguChek XS) and a standard laboratory method (STAGO STA-R).
cAMP-activated Nr4a1 expression requires ERK activity and is modulated by MAPK phosphatase-1 in MA-10 Leydig cells.
Paz et al., Buenos Aires, Argentina. In Mol Cell Endocrinol, Jul 2015
MKP-1 up-regulation, which involves post-translational modifications such as ERK1/2-mediated phosphorylation, reduces ERK1/2 phosphorylation as well as Steroidogenic Acute Regulatory (StAR) protein expression and steroidogenesis.
The binding site specificity of STARD4 subfamily: Breaking the cholesterol paradigm.
LeHoux et al., Sherbrooke, Canada. In Mol Cell Endocrinol, Jul 2015
Steroidogenic acute regulatory protein (StAR)-related lipid transfer (START) domain proteins display diverse expression patterns and cellular localisations.
[Congenital hypofibrinogenemia associated with a novel mutation in FGG gene].
Wang et al., Wenzhou, China. In Zhonghua Yi Xue Yi Chuan Xue Za Zhi, Jun 2015
METHODS: Standard coagulation tests including the prothrombin time (PT), activated partial thromboplastin time (APTT), thrombin time (TT), plasminogen activity (PLG:A), D-Dimer (DD) and fibrin degradation products (FDP) were tested with fresh plasma using a STA-R analyzer.
Membrane receptor cross talk in steroidogenesis: recent insights and clinical implications.
Hammes et al., Rochester, United States. In Steroids, 2013
These kinase signals then activate Steroidogenic Acute Regulatory (StAR) protein, which promotes steroid production.
STARD5 specific ligand binding: comparison with STARD1 and STARD4 subfamilies.
LeHoux et al., Sherbrooke, Canada. In Mol Cell Endocrinol, 2013
We present herein a review of our recent results on the characterization of the binding sites of STARD1, STARD5 and STARD6 using NMR and other biophysical techniques.
Allelic loss of the loci containing the androgen synthesis gene, StAR, is prognostic for relapse in intermediate-risk prostate cancer.
Bristow et al., Toronto, Canada. In Prostate, 2012
Allelic losses of the loci containing StAR have significant prognostic value for intermediate-risk prostate cancer.
Rev-erbα regulates circadian rhythms and StAR expression in rat granulosa cells as identified by the agonist GSK4112.
Hattori et al., Fukuoka, Japan. In Biochem Biophys Res Commun, 2012
StAR is a gene under the dual regulation of Bmal1 and Rev-erba.
Angiotensin II-dependent transcriptional activation of human steroidogenic acute regulatory protein gene by a 25-kDa cAMP-responsive element modulator protein isoform and Yin Yang 1.
Clark et al., Louisville, United States. In Endocrinology, 2012
analysis of angiotensin II-dependent transcriptional activation of human steroidogenic acute regulatory protein gene by a 25-kDa cAMP-responsive element modulator protein isoform and Yin Yang 1
Endoplasmic reticulum stress mediating downregulated StAR and 3-beta-HSD and low plasma testosterone caused by hypoxia is attenuated by CPU86017-RS and nifedipine.
Dai et al., Nanjing, China. In J Biomed Sci, 2011
Downregulated StAR and 3-beta-HSD significantly contribute to low testosterone in hypoxic rats and are associated with ER stress, which mediates testis damage caused by oxygen deprivation.
Gonadal transactivation of STARD1, CYP11A1 and HSD3B.
LaVoie et al., Lubbock, United States. In Front Biosci, 2011
The steroidogenic acute regulatory protein, cytochrome P450 cholesterol side-chain cleavage enzyme and specific 3beta-hydroxysteroid dehydrogenase/delta5-delta4 isomerases initiate the essential process of steroidogenesis in the gonads.
High allele frequency of the p.Q258X mutation and identification of a novel mis-splicing mutation in the STAR gene in Korean patients with congenital lipoid adrenal hyperplasia.
Yoo et al., Seoul, South Korea. In Eur J Endocrinol, 2011
The STAR mutation spectrum has been investigated and a novel STAR mutation functionally analyzed in Korean patients with congenital lipoid adrenal hyperplasia; p.Q258X is the most common STAR mutation in Korea.
Polycystic ovaries and adrenal insufficiency in a young pubescent female with lipoid congenital adrenal hyperplasia due to splice mutation of the StAR gene: a case report and review of the literature.
Brosnan et al., Houston, United States. In J Pediatr Endocrinol Metab, 2010
We report a case of Lipoid Congenital Adrenal Hyperplasia (LCAH) secondary to Steroidogenic Acute Regulatory (StAR) gene mutation in an adolescent female with bilateral ovarian cysts.
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