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Stearoyl-CoA desaturase

Stearoyl-CoA Desaturase, SCD1, stearoyl-CoA desaturase 1
This gene encodes an enzyme involved in fatty acid biosynthesis, primarily the synthesis of oleic acid. Transcripts of approximately 3.9 and 5.2 kb, differing only by alternative polyadenlyation signals, have been detected. A gene encoding a similar enzyme is located on chromosome 4 and a pseudogene of this gene is located on chromosome 17. [provided by RefSeq, Feb 2012] (from NCBI)
Top mentioned proteins: ACID, Insulin, HAD, CAN, Sterol Regulatory Element Binding Protein 1
Papers using Stearoyl-CoA Desaturase antibodies
Synthetic LXR agonist attenuates plaque formation in apoE-/- mice without inducing liver steatosis and hypertriglyceridemia*s⃞
Kratky Dagmar et al., In Journal of Lipid Research, 2006
... Oleoyl-CoA is the major de novo product of stearoyl-CoA desaturase 1 gene isoform and substrate for the biosynthesis of the Harderian gland ...
Papers on Stearoyl-CoA Desaturase
Long noncoding RNA UPAT promotes colon tumorigenesis by inhibiting degradation of UHRF1.
Akiyama et al., Tokyo, Japan. In Proc Natl Acad Sci U S A, Feb 2016
Furthermore, we demonstrate that UHRF1 up-regulates Stearoyl-CoA desaturase 1 and Sprouty 4, which are required for the survival of colon tumor cells.
Altered saturated and monounsaturated plasma phospholipid fatty acid profiles in adult males with colon adenomas.
Fenton et al., United States. In Cancer Epidemiol Biomarkers Prev, Jan 2016
Higher enzyme activity estimates (EAEs) of stearoyl-CoA desaturase-1 (SCD-1, p = 0.02) and elongation of very long chain-6 (Elovl-6, p = 0.03) were associated with an individual being approximately 1.5 times more likely to have an adenoma compared to no polyps.
Growth, carcass and meat quality traits in beef from Angus, Hereford and cross-breed grazing steers, and their association with SNPs in genes related to fat deposition metabolism.
Villarreal et al., Buenos Aires, Argentina. In Meat Sci, Jan 2016
Breed effects were studied, and the association of SNPs with fat deposition and fatty acid (FA) composition (leptin, melanocortin-4 receptor, stearoyl-CoA desaturase, FA synthase and thyroglobulin) was tested.
Methylation analysis in fatty-acid-related genes reveals their plasticity associated with conjugated linoleic acid and calcium supplementation in adult mice.
Serra et al., Palma, Spain. In Eur J Nutr, Jan 2016
Gene expression and methylation degree of CpG sites in promoter sequences of genes involved in fatty acid metabolism, including adiponectin (Adipoq), stearoyl-CoA desaturase (Scd1) and fatty acid synthase (Fasn), were determined by bisulphite sequencing in liver and epididymal white adipose tissue.
Design, radiosynthesis, and evaluation of radiotracers for positron emission tomography imaging of stearoyl-CoA desaturase-1.
Sun et al., Dallas, United States. In Bioorg Med Chem Lett, Jan 2016
UNASSIGNED: Design, radiosynthesis, and biological evaluation of two radiotracers (N-(3-[(18)F]fluoropropyl)-6-(4-(trifluoromethyl)benzoyl)-piperazin-1-yl)pyridazine-3-carboxamide ((18)F-FPPPT) and (N-(4-[(18)F]fluoroaniline)-6-(4-(trifluoromethyl)benzoyl)-piperazin-1-yl)pyridazine-3-carboxamide ((18)F-FAPPT)) are described for noninvasive assessment of stearoyl-CoA desaturase-1 (SCD-1).
Microbiota-Dependent Hepatic Lipogenesis Mediated by Stearoyl CoA Desaturase 1 (SCD1) Promotes Metabolic Syndrome in TLR5-Deficient Mice.
Vijay-Kumar et al., United States. In Cell Metab, Jan 2016
Increased oleate contribution to hepatic lipids and liver SCD1 expression were both microbiota dependent.
Targeting lipid metabolism for the treatment of anaplastic thyroid carcinoma.
Copland et al., Rochester, United States. In Expert Opin Ther Targets, Oct 2015
As stearoyl-CoA desaturase (SCD) is the most differentially expressed constituent of lipid metabolism in ATC, an additional focus on this enzyme as a novel therapeutic target is applied.
Recent progress in the discovery and development of stearoyl CoA desaturase inhibitors.
Uto, Tokyo, Japan. In Chem Phys Lipids, Oct 2015
UNASSIGNED: Stearoyl-CoA desaturase 1 (SCD1) is a rate-limiting enzyme in the biosynthesis of monounsaturated fatty acids from their saturated fatty acid precursors.
Effect of short-chain fatty acids on triacylglycerol accumulation, lipid droplet formation and lipogenic gene expression in goat mammary epithelial cells.
Loor et al., China. In Anim Sci J, Sep 2015
The expression of FABP3, SCD1, PPARG, SREBP1, DGAT1, AGPAT6 and ADRP were upregulated by propionate and butyrate treatment.
X-ray structure of a mammalian stearoyl-CoA desaturase.
Zhou et al., Houston, United States. In Nature, Sep 2015
Stearoyl-CoA desaturase (SCD) is conserved in all eukaryotes and introduces the first double bond into saturated fatty acyl-CoAs.
Stearoyl-CoA Desaturase-1: Is It the Link between Sulfur Amino Acids and Lipid Metabolism?
Schwartz et al., Porto Alegre, Brazil. In Biology (basel), 2014
However, recent evidence has suggested that the enzyme stearoyl-CoA desaturase-1 (SCD-1) may be the link between these two metabolic pathways.
Impaired adipose tissue expandability and lipogenic capacities as ones of the main causes of metabolic disorders.
Tinahones et al., Málaga, Spain. In J Diabetes Res, 2014
Thus, we suggest that this tissue ceases fulfilling its main function, the storage of excess fat, thereby affecting some of the key factors involved in lipogenesis, some of which are reviewed in this paper (PPARγ, ROR1, FASN, SCD1, Rab18, BrCa1, ZAG, and FABP4).
Selective elimination of human pluripotent stem cells by an oleate synthesis inhibitor discovered in a high-throughput screen.
Benvenisty et al., Jerusalem, Israel. In Cell Stem Cell, 2013
Close examination identified this molecule as an inhibitor of stearoyl-coA desaturase (SCD1), the key enzyme in oleic acid biosynthesis, revealing a unique role for lipid metabolism in hPSCs.
Combined deletion of SCD1 from adipose tissue and liver does not protect mice from obesity.
Ntambi et al., Madison, United States. In J Lipid Res, 2012
SCD1 deletion from adipose and/or liver is insufficient to elicit protection from obesity
Stearoyl-CoA Desaturase 1 (SCD1) is a key factor mediating diabetes in MyD88-deficient mice.
Ozawa et al., Hiroshima, Japan. In Gene, 2012
SCD1 was dramatically increased in HFD-fed MyD88-deficient mice liver.
Enzymatic activity and genetic variation in SCD1 modulate the relationship between fatty acids and inflammation.
Mutch et al., Guelph, Canada. In Mol Genet Metab, 2012
SCD1 activity and genetic variation have an important role in modulating the relationship between fatty acids and inflammation in young adults
Association analyses of single nucleotide polymorphisms in bovine stearoyl-CoA desaturase and fatty acid synthase genes with fatty acid composition in commercial cross-bred beef steers.
McAllister et al., Canada. In Anim Genet, 2012
Results suggest that SCD and FASN are strong candidate genes influencing fatty acid composition in beef cattle.
SCD1 inhibition causes cancer cell death by depleting mono-unsaturated fatty acids.
Carter et al., Waltham, United States. In Plos One, 2011
data outline an effective strategy to establish an unambiguous link between fatty acid synthesis and cancer cell survival, and point toward SCD1 as a key target in this pathway
Metabolomics reveals that hepatic stearoyl-CoA desaturase 1 downregulation exacerbates inflammation and acute colitis.
Gonzalez et al., Bethesda, United States. In Cell Metab, 2008
DSS-elicited inhibition of SCD1 expression in liver. This decrease occurred prior to the symptoms of acute colitis and was well correlated with elevated expression of proinflammatory cytokines
Hepatic stearoyl-CoA desaturase-1 deficiency protects mice from carbohydrate-induced adiposity and hepatic steatosis.
Ntambi et al., Madison, United States. In Cell Metab, 2007
hepatic SCD1 expression (and thus, oleate) is required for carbohydrate-induced adiposity, but SCD1 inhibition in extrahepatic tissues is required to protect mice from high-fat-induced obesity and insulin resistance
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