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Heat shock protein 70kDa family, member 13

The protein encoded by this gene is a member of the heat shock protein 70 family and is found associated with microsomes. Members of this protein family play a role in the processing of cytosolic and secretory proteins, as well as in the removal of denatured or incorrectly-folded proteins. The encoded protein contains an ATPase domain and has been shown to associate with a ubiquitin-like protein. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: HSP70, ATPase, ACID, CAN, Ubiquitin
Papers on STCH
Chaperone stress 70 protein (STCH) binds and regulates two acid/base transporters NBCe1-B and NHE1.
Park et al., Seoul, South Korea. In J Biol Chem, 2013
We identified Hsp70-like stress 70 protein chaperone (STCH) as interacting with NBCe1-B at the N-terminal (amino acids 96-440) region.
Overexpression of the Hspa13 (Stch) gene reduces prion disease incubation time in mice.
Lloyd et al., London, United Kingdom. In Proc Natl Acad Sci U S A, 2012
Hspa13 (Stch) gene has a role in prion disease incubation time in mice
Malignant and nonmalignant gene signatures in squamous head and neck cancer.
Schweitzer et al., Detroit, United States. In J Oncol, 2011
Loss of BAK1 and CCND1 and gain of STCH predicted nontumor.
[Adenosine triphosphate-binding gene messenger ribonucleic acid expression in brains of drug-resistant epileptics].
Wang et al., Chongqing, China. In Zhonghua Yi Xue Za Zhi, 2011
The rates of Cy5/Cy3 were CDC2L5 2.159, ROCK1 2.538, STCH 2.106, OXSR1 3.791 and ABCB6 2.583 respectively.
[Identification of candidate genes of autism on the basis of molecular cytogenetic and in silico studies of the genome organization of chromosomal regions involved in unbalanced rearrangements].
Iurov et al., In Genetika, 2010
The following candidate genes were identified in children with autism by in silico analysis: SCARB2, TPPP, PDCD6, SEPT5, GP1BB, PI4KA, NPTX1, STCH, NRIP1, and CXADR.
Chemical manipulation of hsp70 ATPase activity regulates tau stability.
Dickey et al., Tampa, United States. In J Neurosci, 2009
An entirely novel path is revealed toward therapeutic intervention of tauopathies by inhibition of the previously untargeted ATPase activity of Hsp70.
Stomach cancer-derived del223V-226L mutation of the STCH gene causes loss of sensitization to TRAIL-mediated apoptosis.
Yamamoto et al., Fukuoka, Japan. In Biochem Biophys Res Commun, 2008
These results suggest that STCH has a role in cell survival via modulation of the TRAIL-mediated cell death pathway.
Genetic control of experience-dependent plasticity in the visual cortex.
Levelt et al., Amsterdam, Netherlands. In Genes Brain Behav, 2008
The locus encompasses 13 genes, two of which--Stch and Nrip1--contain missense polymorphisms.
A genomewide analysis of genes for the heat shock protein 70 chaperone system in the ascidian Ciona intestinalis.
Satoh et al., Kawaguchi, Japan. In Cell Stress Chaperones, 2005
Members of the STCH subfamily of the HSP70 family and members of the HSPA14 subfamily of the HSP110 family are conserved between humans and protostomes but were not found in Ciona.
A genetic variant in the gene encoding the stress70 protein chaperone family member STCH is associated with gastric cancer in the Japanese population.
Sasazuki et al., Fukuoka, Japan. In Biochem Biophys Res Commun, 2005
in the Japanese population, STCH might be a new candidate for conferring susceptibility to gastric cancer
Identification and characterization of an ataxin-1-interacting protein: A1Up, a ubiquitin-like nuclear protein.
Orr et al., Minneapolis, United States. In Hum Mol Genet, 2000
In addition, A1Up has substantial homology to human Chap1/Dsk2, a protein that binds the ATPase domain of the HSP70-like Stch protein.
A family of ubiquitin-like proteins binds the ATPase domain of Hsp70-like Stch.
Rose et al., Bethesda, United States. In Febs Lett, 2000
We have isolated two human ubiquitin-like (UbL) proteins that bind to a short peptide within the ATPase domain of the Hsp70-like Stch protein.
A 'core ATPase', Hsp70-like structure is conserved in human, rat, and C. elegans STCH proteins.
Kaye et al., Bethesda, United States. In Gene, 1997
We have identified the rat and Caenorhabditis elegans homologues of a 'core ATPase'-encoding Hsp70-like gene, designated Stch.
Stch encodes the 'ATPase core' of a microsomal stress 70 protein.
Kaye et al., Bethesda, United States. In Embo J, 1994
We have cloned a human cDNA, designated Stch, that is conserved in rat tissues and which encodes a novel microsome-associated member of the stress70 protein chaperone family.
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