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Staufen, RNA binding protein, homolog 2

Stau2, 39K2, Staufen 2
Staufen homolog 2 is a member of the family of double-stranded RNA (dsRNA)-binding proteins involved in the transport and/or localization of mRNAs to different subcellular compartments and/or organelles. These proteins are characterized by the presence of multiple dsRNA-binding domains which are required to bind RNAs having double-stranded secondary structures. Staufen homolog 2 shares 48.5% and 59.9% similarity with drosophila and human staufen, respectively. The exact function of Staufen homolog 2 is not known, but since it contains 3 copies of conserved dsRNA binding domain, it could be involved in double-stranded RNA binding events. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2009] (from NCBI)
Top mentioned proteins: Staufen, V1a, WAVE, caspase-3, MAP2
Papers on Stau2
Selenoprotein W expression and regulation in mouse brain and neurons.
Berry et al., Honolulu, United States. In Brain Behav, 2013
Lastly, Sepw1 mRNA coimmunoprecipitates with Staufen 2 protein in a human neuronal cell line.
Staufen-mediated mRNA decay.
Maquat et al., Rochester, United States. In Wiley Interdiscip Rev Rna, 2013
Recently, STAU2, a paralog of STAU1, has also been reported to mediate SMD.
Staufen2 functions in Staufen1-mediated mRNA decay by binding to itself and its paralog and promoting UPF1 helicase but not ATPase activity.
Maquat et al., Rochester, United States. In Proc Natl Acad Sci U S A, 2013
We show that SMD involves not only STAU1 but also its paralog STAU2.
The double-stranded RNA-binding protein Staufen 2 regulates eye size.
Monnier et al., Toronto, Canada. In Mol Cell Neurosci, 2012
Mammalian Staufen 2 (Stau2) is a double-stranded mRNA binding protein known to regulate dendrite formation in vitro as well as cell survival and migration in vivo.
Independent localization of MAP2, CaMKIIα and β-actin RNAs in low copy numbers.
Kiebler et al., Vienna, Austria. In Embo Rep, 2011
The number of MAP2 molecules per particle is affected by synaptic activity and Staufen 2, indicating that RNP composition is tightly controlled.
Staufen 2 regulates mGluR long-term depression and Map1b mRNA distribution in hippocampal neurons.
Lacaille et al., Montréal, Canada. In Learn Mem, 2010
We suggest a role for Stau2 in the generation and regulation of Map1b mRNA containing granules that are required for mGluR-long-term depression
Cell type-dependent gene regulation by Staufen2 in conjunction with Upf1.
Yoneda et al., Suita, Japan. In Bmc Mol Biol, 2010
Recruitment of Stau2 alone or in combination with Upf1 differentially affects the fate of mRNAs.
Genome wide identification of Staufen2-bound mRNAs in embryonic rat brains.
DesGroseillers et al., Montréal, Canada. In Bmb Rep, 2010
These results represent an additional and important step in the characterization of Staufen2- mediated neuronal functions in rat brains.
Molecular composition of staufen2-containing ribonucleoproteins in embryonic rat brain.
DesGroseillers et al., Montréal, Canada. In Plos One, 2009
provide new tools to study and understand how Stau2-containing mRNPs are transported, translationally silenced during transport and/or locally expressed according to cell needs
Role of mitogen-activated protein kinase (MAPK) docking sites on Staufen2 protein in dendritic mRNA transport.
Kim et al., Ch'ŏngju, South Korea. In Biochem Biophys Res Commun, 2008
These results suggest that the MAPK pathway could modulate dendritic mRNA transport through its interaction with Staufen2.
Bovine oocytes and early embryos express Staufen and ELAVL RNA-binding proteins.
Watson et al., London, Canada. In Zygote, 2008
STAU1 & STAU2 & ELAVL1 mRNAs & proteins were detected throughout cow preimplantation development from the germinal vesicle (GV) oocyte to the blastocyst stage; ELAVL2 mRNAs were detectable from the GV to the morula stage; ELAVL2 protein was in all stages
Functional genomics analysis of low concentration of ethanol in human hepatocellular carcinoma (HepG2) cells. Role of genes involved in transcriptional and translational processes.
Jung et al., Dortmund, Germany. In Int J Med Sci, 2006
The pairwise comparison analysis demonstrated four significantly up-regulated (COBRA1, ITGB4, STAU2, and HMGN3) genes and one down-regulated (ANK3) gene.
The RNA binding and transport proteins staufen and fragile X mental retardation protein are expressed by rat primary afferent neurons and localize to peripheral and central axons.
Hargreaves et al., San Antonio, United States. In Neuroscience, 2006
Rat DRG and TG neurons expressed staufen (stau) 1 and 2 (detected at the mRNA level) and stau2 and fragile x mental retardation protein (FMRP; detected at the protein level).
The zinc-finger protein ZFR is critical for Staufen 2 isoform specific nucleocytoplasmic shuttling in neurons.
DesGroseillers et al., Montréal, Canada. In J Neurochem, 2006
zinc finger RNA binding protein is a native component of Staufen2-containing granules and likely plays its role during early steps of RNA transport and localization
Experimental study of the 39K2 2 3Pi(g) state by perturbation facilitated infrared-infrared double resonance and two-photon excitation spectroscopy.
Lyyra et al., Beijing, China. In J Chem Phys, 2005
The 39K2 2 3Pi(g) state has been observed by perturbation facilitated infrared-infrared double resonance and two-photon excitations.
Learning from the acquired optimized pulse shapes about the isotope selective ionization of potassium dimers.
Wöste et al., Berlin, Germany. In J Chem Phys, 2005
Selective optimization of the 39,39K2 and 39,41K2 isotopomers in a three-photon ionization process is presented by applying evolution strategies on shaped fs pulses in a feedback loop.
Staufen recruitment into stress granules does not affect early mRNA transport in oligodendrocytes.
Boccaccio et al., Buenos Aires, Argentina. In Mol Biol Cell, 2005
Staufen 1 and Staufen 2 are novel and ubiquitous stress granules components that are involved in repositioning of most polysomal mRNAs, but not of recently synthesized transcripts, during the stress response
Differential effects of Rho GTPases on axonal and dendritic development in hippocampal neurones.
Just et al., Berlin, Germany. In J Neurochem, 2004
Inactivation of Rho by C3-catalysed ADP-ribosylation using C3 isoforms (Clostridium limosum, C3(lim) or Staphylococcus aureus, C3(stau2)), diminished axonal branching.
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