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Stabilin 1

stabilin-1, CLEVER-1, FEEL-1, MS-1 antigen, STAB1
This gene encodes a large, transmembrane receptor protein which may function in angiogenesis, lymphocyte homing, cell adhesion, or receptor scavenging. The protein contains 7 fasciclin, 16 epidermal growth factor (EGF)-like, and 2 laminin-type EGF-like domains as well as a C-type lectin-like hyaluronan-binding Link module. The protein is primarily expressed on sinusoidal endothelial cells of liver, spleen, and lymph node. The receptor has been shown to endocytose ligands such as low density lipoprotein, Gram-positive and Gram-negative bacteria, and advanced glycosylation end products. Supporting its possible role as a scavenger receptor, the protein rapidly cycles between the plasma membrane and early endosomes. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: V1a, Hare, CAN, IL-4, AGE
Papers on stabilin-1
Expression of pro-angiogenic genes in mesenchymal stem cells derived from dermis of patients with psoriasis.
Zhang et al., Taiyuan, China. In Int J Dermatol, Feb 2016
Our microarray analysis suggested that the pro-angiogenic genes platelet endothelial cell adhesion molecule-1 (PECAM1), facio-genital dysplasia-5 (FGD5), prostaglandin-endoperoxide synthase-1 (PTGS1), melanoma cell adhesion molecule (MCAM), vasohibin-2 (VASH2), and stabilin-1 (STAB1) are differentially expressed in dermal mesenchymal stem cells in psoriasis.
Monocyte Stabilin-1 Suppresses the Activation of Th1 Lymphocytes.
Salmi et al., Turku, Finland. In J Immunol, Feb 2016
In this study, we analyzed the putative functions of stabilin-1 in blood monocytes.
A combinatorial αβ T cell receptor expressed by macrophages in the tumor microenvironment.
Kaminski et al., Mannheim, Germany. In Immunobiology, Nov 2015
Furthermore, we routinely find TCRαβ(+) macrophage subpopulations in experimental tumors (TS/A, mammary adenocarcinoma) which we induced both in normal mice and mice deficient in the macrophage receptor stabilin-1.
CD68+, but not stabilin-1+ tumor associated macrophages in gaps of ductal tumor structures negatively correlate with the lymphatic metastasis in human breast cancer.
Kzhyshkowska et al., Tomsk, Russia. In Immunobiology, Oct 2015
Immunohistochemical and immunofluorescence/confocal microcopy analysis was used to detect CD68 and stabilin-1 in 5 different tumor segments: (1) areas with soft fibrous stroma; (2) areas with coarse fibrous stroma; (3) areas of maximum stromal-and-parenchymal relationship; (4) parenchymal elements; (5) gaps of ductal tumor structures.
Surface modification of biomaterials based on high-molecular polylactic acid and their effect on inflammatory reactions of primary human monocyte-derived macrophages: perspective for personalized therapy.
Kzhyshkowska et al., Tomsk, Russia. In Mater Sci Eng C Mater Biol Appl, Jun 2015
Type 1 and type 2 inflammatory cytokines (TNFα, CCL18) secretion and histological biomarkers (CD206, stabilin-1) expression were analyzed by ELISA and confocal microscopy respectively.
Clever-1/stabilin-1 controls cancer growth and metastasis.
Jalkanen et al., Turku, Finland. In Clin Cancer Res, 2015
Clever-1/Stabilin-1, a multifunctional scavenger and adhesion receptor, is constitutively present on a subset of type II macrophages and lymphatic endothelium, but its functional role in cancer is unknown.
Tumor-Associated Macrophages Provide Significant Prognostic Information in Urothelial Bladder Cancer.
Boström et al., Turku, Finland. In Plos One, 2014
CD68 (pan-macrophage marker), MAC387 (polarized towards type 1 macrophages), and CLEVER-1/Stabilin-1 (type 2 macrophages and lymphatic/blood vessels) were detected immunohistochemically.
Investigation of manic and euthymic episodes identifies state- and trait-specific gene expression and STAB1 as a new candidate gene for bipolar disorder.
Rietschel et al., Mannheim, Germany. In Transl Psychiatry, 2013
In the GWAS data integration analysis, one gene (STAB1) remained significant (P=1.9 × 10(-4)) after adjustment for multiple testing.
Whole-genome sequence analysis reveals differences in population management and selection of European low-input pig breeds.
Crooijmans et al., Wageningen, Netherlands. In Bmc Genomics, 2013
IL12RB2 and STAB1-, probably as a result of strong artificial in the intensive production systems in pig.
Novel monocyte biomarkers of atherogenic conditions.
Kzhyshkowska et al., Mannheim, Germany. In Curr Pharm Des, 2012
These include stabilin-1, FOXQ1 and IL17RB.
Monocytes as a diagnostic marker of cardiovascular diseases.
Kzhyshkowska et al., Mannheim, Germany. In Immunobiology, 2012
Further surface markers of monocytes found to be associated with cardiovascular diseases are CD18, CD11b, CXCR1, CD36 and STAB1.
Stabilin-1/CLEVER-1, a type 2 macrophage marker, is an adhesion and scavenging molecule on human placental macrophages.
Salmi et al., Turku, Finland. In Eur J Immunol, 2011
macrophage stabilin-1/CLEVER-1 can potentially regulate leukocyte migration and scavenging during the development of the placenta and fetus
Common lymphatic endothelial and vascular endothelial receptor-1 mediates the transmigration of regulatory T cells across human hepatic sinusoidal endothelium.
Adams et al., Birmingham, United Kingdom. In J Immunol, 2011
CLEVER-1/stabilin-1 can support lymphocyte transendothelial migration; it also may provide an organ-specific signal for regulatory T cell recruitment to the inflamed liver and to hepatocellular carcinoma.
Identification of a sequence in the matricellular protein SPARC that interacts with the scavenger receptor stabilin-1.
Sage et al., Seattle, United States. In J Cell Biochem, 2011
Studies identified a binding site on SPARC for stabilin-1 by a solid-state peptide array coupled with a modified enzyme-linked immunosorbent assay.
Lymphatic expression of CLEVER-1 in breast cancer and its relationship with lymph node metastasis.
Martin et al., Nottingham, United Kingdom. In Anal Cell Pathol (amst), 2010
The associations between CLEVER-1 expression on endothelial vessels and macrophage/leukocyte infiltration is suggestive of its regulation by inflammatory conditions in breast cancer, most likely by macrophage-associated cytokines.
Meta-analysis identifies 13 new loci associated with waist-hip ratio and reveals sexual dimorphism in the genetic basis of fat distribution.
Lindgren et al., Regensburg, Germany. In Nat Genet, 2010
We identified 13 new loci in or near RSPO3, VEGFA, TBX15-WARS2, NFE2L3, GRB14, DNM3-PIGC, ITPR2-SSPN, LY86, HOXC13, ADAMTS9, ZNRF3-KREMEN1, NISCH-STAB1 and CPEB4 (P = 1.9 × 10⁻⁹ to P = 1.8 × 10⁻⁴⁰) and the known signal at LYPLAL1.
Multifunctional receptor stabilin-1 in homeostasis and disease.
Kzhyshkowska, Mannheim, Germany. In Scientificworldjournal, 2009
Studies shoe that understanding stabilin-1 behavior in complex biological systems and would open perspectives for therapeutic targeting of stabilin-1 pathways in chronic inflammation.
Interactions between advanced glycation end-products (AGE) and their receptors in the development and progression of diabetic nephropathy - are these receptors valid therapeutic targets.
Forbes et al., Melbourne, Australia. In Curr Drug Targets, 2009
AGEs elicit their receptor mediated effects via their engagement with numerous receptors and binding proteins which are broadly thought to be either inflammatory (RAGE and AGE-R2) or clearance receptors (AGE-R1, AGE-R3, CD36, Scr-II, FEEL-1 and FEEL-2).
Cross-talk between endocytic clearance and secretion in macrophages.
Krusell et al., Mannheim, Germany. In Immunobiology, 2008
role in endocytic clearance and secretion in macrophages; review
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