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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Dec 2016.

WSC2 Wsc2p

STA3, WSC2, ARHGEF3, Wsc2p
Rho-like GTPases are involved in a variety of cellular processes, and they are activated by binding GTP and inactivated by conversion of GTP to GDP by their intrinsic GTPase activity. Guanine nucleotide exchange factors (GEFs) accelerate the GTPase activity of Rho GTPases by catalyzing their release of bound GDP. This gene encodes a guanine nucleotide exchange factor, which specifically activates two members of the Rho GTPase family: RHOA and RHOB, both of which have a role in bone cell biology. It has been identified that genetic variation in this gene plays a role in the determination of bone mineral density (BMD), indicating the implication of this gene in postmenopausal osteoporosis. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: MID2, CAN, OUT, Actin, Rhodopsin
Papers on STA3
Next-generation sequencing reveals novel rare fusion events with functional implication in prostate cancer.
Jenster et al., Rotterdam, Netherlands. In Oncogene, Mar 2015
Two gene fusions were in-frame: MPP5-FAM71D in PC346C and ARHGEF3-C8ORF38 in G089.
ARHGEF3 controls HDACi-induced differentiation via RhoA-dependent pathways in acute myeloid leukemias.
Altucci et al., Napoli, Italy. In Epigenetics, 2014
Here, we analyzed the regulation of ARHGEF3, a RhoA-specific guanine nucleotide exchange factor, by the HDACi MS275 (entinostat).
Yeast phospholipid biosynthesis is linked to mRNA localization.
Jansen et al., Tübingen, Germany. In J Cell Sci, 2014
In a screen for ER-specific proteins necessary for the directional transport of WSC2 and EAR1 mRNAs, we have identified enzymes that are involved in phospholipid metabolism.
Influence of ARHGEF3 and RHOA knockdown on ACTA2 and other genes in osteoblasts and osteoclasts.
Wilson et al., Australia. In Plos One, 2013
We have previously identified associations between variation in two related genes located in 3p14-p22, ARHGEF3 and RHOA, and BMD in women.
The nuclear factor κB family member RelB facilitates apoptosis of renal epithelial cells caused by cisplatin/tumor necrosis factor α synergy by suppressing an epithelial to mesenchymal transition-like phenotypic switch.
de Graauw et al., Leiden, Netherlands. In Mol Pharmacol, 2013
Indeed, gene array analysis revealed that knockdown of RelB was associated with upregulation of several actin regulatory genes, including Snai2 and the Rho GTPase proteins Rhophilin and Rho guanine nucleotide exchange factor 3 (ARHGEF3).
GWAS of blood cell traits identifies novel associated loci and epistatic interactions in Caucasian and African-American children.
Sleiman et al., Philadelphia, United States. In Hum Mol Genet, 2013
In African Americans, we report five novel associations of HBE1 variants with HCT and MCHC, the alpha-globin gene cluster variants with RBC and MCHC, and a variant at the ARHGEF3 locus with PLT, as well as replication of four previously reported loci at genome-wide significance.
Localization of a subset of yeast mRNAs depends on inheritance of endoplasmic reticulum.
Jansen et al., Tübingen, Germany. In Traffic, 2012
These mRNAs include WSC2, IST2, EAR1 and SRL1 that encode membrane or ER associated proteins and are expressed during S and G2 phases of the cell cycle when tubular ER movement into the bud occurs.
Phylogenetic origin and transcriptional regulation at the post-diauxic phase of SPI1, in Saccharomyces cerevisiae.
Aranda et al., Paterna, Spain. In Cell Mol Biol Lett, 2012
In terms of regulation, we have found that the expression in the post-diauxic phase is regulated by genes related to the PKA pathway and stress response (MSN2/4, YAK1, POP2, SOK2, PHD1, and PHO84) and by genes involved in the PKC pathway (WSC2, PKC1, and MPK1).
Interactions of single nucleotide polymorphisms with dietary calcium intake on the risk of metabolic syndrome.
Kim et al., Seoul, South Korea. In Am J Clin Nutr, 2012
Among 27 single nucleotide polymorphisms (SNPs) selected as possible candidate gene polymorphisms affecting the risk of metabolic syndrome, 3 SNPs [rs6445834 in Rho guanine nucleotide exchange factor 3 (ARHGEF3), rs10850335 in T-box 5 (TBX5), rs180349 in BUD13 homolog (Saccaromyces cerevisiae) (BUD13)] showed significant interaction effects with calcium intake tertiles or sufficiency in both men and women.
Silencing of RhoA nucleotide exchange factor, ARHGEF3, reveals its unexpected role in iron uptake.
Freson et al., Cambridge, United Kingdom. In Blood, 2011
An example is the Rho guanine nucleotide exchange factor, ARHGEF3, which was previously implicated by genomewide association meta-analysis studies in bone cell biology.
How do I begin? Sensing extracellular stress to maintain yeast cell wall integrity.
Heinisch et al., Osnabrück, Germany. In Eur J Cell Biol, 2011
In the Baker's yeast Saccharomyces cerevisiae, a set of five membrane-spanning sensors, namely Wsc1, Wsc2, Wsc3, Mid2 and Mtl1, detect perturbations in the cell wall and/or the plasma membrane and activate a downstream signal transduction pathway with a central MAP kinase module.
Genome-wide association study of rheumatoid arthritis in Koreans: population-specific loci as well as overlap with European susceptibility loci.
Bae et al., New York City, United States. In Arthritis Rheum, 2011
In addition, we observed replication signals near the genes PTPN2, FLI1, ARHGEF3, LCP2, GPR137B, TRHDE, and CGA1.
A novel mRNA affinity purification technique for the identification of interacting proteins and transcripts in ribonucleoprotein complexes.
Gerst et al., Israel. In Rna, 2010
Finally, RaPID could also be used to show biochemically the coexistence of different RNA species within the same RNP complex (e.g., coprecipitation of the yeast SRO7, WSC2, SEC3, and IST2 mRNAs with ASH1 mRNA) for the first time.
A block of endocytosis of the yeast cell wall integrity sensors Wsc1 and Wsc2 results in reduced fitness in vivo.
Heinisch et al., Osnabrück, Germany. In Mol Genet Genomics, 2010
Data show that Wsc1 uses a clathrin-dependent NPFDD signal, Wsc2 relies on a specific lysine residue (K495).
Together we are strong--cell wall integrity sensors in yeasts.
Heinisch et al., Oviedo, Spain. In Yeast, 2010
Wsc1, Wsc2, Wsc3, Mid2 and Mtl1.
Common variants in FLNB/CRTAP, not ARHGEF3 at 3p, are associated with osteoporosis in southern Chinese women.
Huang et al., Hong Kong, Hong Kong. In Osteoporos Int, 2010
the association between rs7646054 in ARHGEF3 and bone mineral density observed in Caucasians was not replicated in the chinese samples.
Identification of a role for the ARHGEF3 gene in postmenopausal osteoporosis.
Wilson et al., Australia. In Am J Hum Genet, 2008
genetic variation in ARHGEF3 plays a role in the determination of bone density in Caucasian women. This data implicates the RhoGTPase-RhoGEF pathway in osteoporosis.
XPLN, a guanine nucleotide exchange factor for RhoA and RhoB, but not RhoC.
Wennerberg et al., Chapel Hill, United States. In J Biol Chem, 2002
a guanine nucleotide exchange factor for RhoA and RhoB, but not RhoC
The glucoamylase multigene family in Saccharomyces cerevisiae var. diastaticus: an overview.
Marmur et al., Stellenbosch, South Africa. In Crit Rev Biochem Mol Biol, 1990
II), and STA3 (chr.
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