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Syndecan binding protein

ST1, Syntenin, syntenin-1
The protein encoded by this gene was initially identified as a molecule linking syndecan-mediated signaling to the cytoskeleton. The syntenin protein contains tandemly repeated PDZ domains that bind the cytoplasmic, C-terminal domains of a variety of transmembrane proteins. This protein may also affect cytoskeletal-membrane organization, cell adhesion, protein trafficking, and the activation of transcription factors. The protein is primarily localized to membrane-associated adherens junctions and focal adhesions but is also found at the endoplasmic reticulum and nucleus. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: CAN, HAD, stromelysin-3, ACID, OUT
Papers on ST1
MDA-9/Syntenin Control.
Dasgupta et al., Tyler, United States. In J Cell Physiol, Mar 2016
MDA-9/Syntenin is a small PDZ domain containing scaffolding protein with diverse array of functions regulating membrane trafficking, cell adhesion, neural, and synaptic development, ubiquitination, and exosome biogenesis.
Proteomic peptide phage display uncovers novel interactions of the PDZ1-2 supramodule of syntenin.
Ivarsson et al., Marseille, France. In Febs Lett, Jan 2016
Syntenin has crucial roles in cell adhesion, cell migration and synaptic transmission.
Genome-Based Infection Tracking Reveals Dynamics of Clostridium difficile Transmission and Disease Recurrence.
Lawley et al., London, United Kingdom. In Clin Infect Dis, Jan 2016
We describe a whole-genome phylogenetic-based method to track the transmission of individual clones in infected hospital patients from the epidemic C. difficile 027/ST1 lineage, and to distinguish between the 2 causes of recurrent disease, relapse (same strain), or reinfection (different strain).
Changing epidemiology of group B streptococcal infections among adults in Iceland: 1975-2014.
Ramirez et al., Lisbon, Portugal. In Clin Microbiol Infect, Jan 2016
On the other hand, the increase in frequency of CC1 was caused by two lineages expressing distinct serotypes: ST1/V/alp3 and ST196/IV/eps.
Syntenin is expressed in human gliomas and may correlate with tumor migration.
Wang et al., Chongqing, China. In Arch Med Sci, Jan 2016
Syntenin has been demonstrated to be implicated in the migration, invasion and metastasis of many types of malignant tumors.
Molecular Characterization and Subtyping of Blastocystis Species in Irritable Bowel Syndrome Patients from North India.
Chaudhry et al., New Delhi, India. In Plos One, Dec 2015
Isolates of Blastocystis sp.were subtyped using Sequence Tagged Site and representative samples were sequenced at SSUrRNA locus.A total of sixty five isolates of Blastocystis sp. were identified [IBS (n = 50); Controls (n = 15)] of which 91% belonged to ST3 and 9% belonged to ST1.
The First Two Clostridium difficile Ribotype 027/ST1 Isolates Identified in Beijing, China-an Emerging Problem or a Neglected Threat?
Xu et al., Beijing, China. In Sci Rep, Dec 2015
Both C. difficile isolates had the typical PCR ribotype 027 profile; were positive for tcdA, tcdB and binary toxin genes; belonged to multilocus sequence type 1 (ST1); had typical ribotype 027 deletions in the tcdC gene; and were highly-resistant to fluoroquinolones; but had a different MLVA profile and were not genetically related to any previously reported international ribotype 027 clones.
Syntenin and syndecan in the biogenesis of exosomes.
Zimmermann et al., Marseille, France. In Biol Cell, Oct 2015
In this review, we recapitulate recent insight on the role of the syndecan (SDC) heparan sulphate proteoglycans, the small intracellular adaptor syntenin and associated regulators in the biogenesis and loading of exosomes with cargo.
PDZ Protein Regulation of G Protein-Coupled Receptor Trafficking and Signaling Pathways.
Ferguson et al., London, Canada. In Mol Pharmacol, Oct 2015
These PDZ domain-containing proteins include the membrane-associated guanylate-like kinases [postsynaptic density protein of 95 kilodaltons; synapse-associated protein of 97 kilodaltons; postsynaptic density protein of 93 kilodaltons; synapse-associated protein of 102 kilodaltons; discs, large homolog 5; caspase activation and recruitment domain and membrane-associated guanylate-like kinase domain-containing protein 3; membrane protein, palmitoylated 3; calcium/calmodulin-dependent serine protein kinase; membrane-associated guanylate kinase protein (MAGI)-1, MAGI-2, and MAGI-3], Na(+)/H(+) exchanger regulatory factor proteins (NHERFs) (NHERF1, NHERF2, PDZ domain-containing kidney protein 1, and PDZ domain-containing kidney protein 2), Golgi-associated PDZ proteins (Gα-binding protein interacting protein, C-terminus and CFTR-associated ligand), PDZ domain-containing guanine nucleotide exchange factors (GEFs) 1 and 2, regulator of G protein signaling (RGS)-homology-RhoGEFs (PDZ domain-containing RhoGEF and leukemia-associated RhoGEF), RGS3 and RGS12, spinophilin and neurabin-1, SRC homology 3 domain and multiple ankyrin repeat domain (Shank) proteins (Shank1, Shank2, and Shank3), partitioning defective proteins 3 and 6, multiple PDZ protein 1, Tamalin, neuronal nitric oxide synthase, syntrophins, protein interacting with protein kinase C α 1, syntenin-1, and sorting nexin 27.
Protective effects of aspirin and vitamin C against corn syrup consumption-induced cardiac damage through sirtuin-1 and HIF-1α pathway.
Savran et al., Isparta, Turkey. In Anatol J Cardiol, Oct 2015
OBJECTIVE: The aim of this study was to investigate the protective effects of aspirin (AS) and vitamin C (VC) against cardiac damage induced by chronic corn syrup (CS) consumption via a mechanism involving sirtuin-1 (ST-1), hypoxia-inducible factor-1α (HIF-1α), and the caspase-3 pathway in rats.
Targeting tumor invasion: the roles of MDA-9/Syntenin.
Fisher et al., Richmond, United States. In Expert Opin Ther Targets, 2015
INTRODUCTION: Melanoma differentiation-associated gene - 9 (MDA-9)/Syntenin has become an increasingly popular focus for investigation in numerous cancertypes.
Functional characteristics of the Staphylococcus aureus δ-toxin allelic variant G10S.
Otto et al., Bethesda, United States. In Sci Rep, 2014
This variant is a characteristic of the subspecies S. argenteus and S. aureus sequence types ST1 and ST59, the latter representing the most frequent cause of community-associated infections in Asia.
Examination of Epigenetic and other Molecular Factors Associated with mda-9/Syntenin Dysregulation in Cancer Through Integrated Analyses of Public Genomic Datasets.
Fisher et al., Richmond, United States. In Adv Cancer Res, 2014
mda-9/Syntenin (melanoma differentiation-associated gene 9) is a PDZ domain containing, cancer invasion-related protein.
Syndecan-syntenin-ALIX regulates the biogenesis of exosomes.
David et al., Leuven, Belgium. In Nat Cell Biol, 2012
Here, we report evidence that the syndecan heparan sulphate proteoglycans and their cytoplasmic adaptor syntenin control the formation of exosomes.
The PDZ-adaptor protein syntenin-1 regulates HIV-1 entry.
Sánchez-Madrid et al., Madrid, Spain. In Mol Biol Cell, 2012
Data show that syntenin-1 is recruited to the plasma membrane during HIV-1 attachment.
Syntenin-mediated regulation of Sox4 proteasomal degradation modulates transcriptional output.
Coffer et al., Utrecht, Netherlands. In Oncogene, 2012
our data demonstrate that the Sox4 C-terminal domain regulates polyubiquitin-independent proteasomal degradation of Sox4 that can be modulated by interaction with syntenin
Association of syntenin-1 with M-RIP polarizes Rac-1 activation during chemotaxis and immune interactions.
Yáñez-Mó et al., Madrid, Spain. In J Cell Sci, 2012
the key role of syntenin-1 is the generation of functional asymmetry in T cells and provide a novel mechanistic link between receptor activation and actin polymerization and accumulation in response to extracellular stimulation.
MDA-9/syntenin: a positive gatekeeper of melanoma metastasis.
Fisher et al., Richmond, United States. In Front Biosci, 2011
MDA-9/syntenin functions as a positive regulator of melanoma progression and metastasis through interactions with c-Src and promotes the formation of an active FAK/c-Src signaling complex leading to NF-k B and matrix metalloproteinase activation. Review.
Mda-9/syntenin is expressed in uveal melanoma and correlates with metastatic progression.
Ferrini et al., Genova, Italy. In Plos One, 2011
mda-9/syntenin is involved in uveal melanoma progression
Cytokine-specific transcriptional regulation through an IL-5Ralpha interacting protein.
Coffer et al., Utrecht, Netherlands. In Science, 2001
We show that syntenin, a protein containing PSD-95/Discs large/zO-1 (PDZ) domains, associates with the cytoplasmic tail of the IL-5Ralpha.
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