SSX2-4 expression in early-stage non-small cell lung cancer.
Odense, Denmark. In Tissue Antigens, 2014
The expression of cancer/testis antigens SSX2, SSX3, and SSX4 in non-small cell lung cancers (NSCLC) was examined, since they are considered promising targets for cancer immunotherapy due to their immunogenicity and testis-restricted normal tissue expression.
Expression of cancer-testis antigen in multiple myeloma.
Wuhan, China. In J Huazhong Univ Sci Technolog Med Sci, 2014
Reverse transcriptase-polymerase chain reaction (RT-PCR) was used to detect the mRNA expression of MAGE-C1/CT7, SSX1, SSX2 and SSX4 in MM cell lines of RPMI-8226 and U266, and bone marrow (BM) cells of 25 MM patients and 18 healthy volunteers.
Effects of CT-Xp gene knock down in melanoma cell lines.
New York City, United States. In Oncotarget, 2013
We found that of these, those specific to GAGE and XAGE1 most significantly impeded melanoma cell migration and invasion and those specific to SSX4 and XAGE1 decreased the clonogenic survival of melanoma cells.
Pattern and clinical significance of cancer-testis gene expression in head and neck squamous cell carcinoma.
Genève, Switzerland. In Int J Cancer, 2011
The pattern and level of expression of 12 CT genes (MAGE-A1, MAGE-A3, MAGE-A4, MAGE-A10, MAGE-C2, NY-ESO-1, LAGE-1, SSX-2, SSX-4, BAGE, GAGE-1/2, GAGE-3/4) and the tumor-associated antigen encoding genes PRAME, HERV-K-MEL, and NA-17A were evaluated by RT-PCR in a panel of 57 primary HNSCC.
Expression of cancer-testis genes in brain tumors.
Taegu, South Korea. In J Korean Neurosurg Soc, 2008
METHODS: We investigated the expression of 6 CT genes (MAGE-E1, SOX-6, SCP-1, SSX-2, SSX-4, and HOM-TES-85) using reverse-transcription polymerase chain reaction in 26 meningiomas and 32 other various brain tumor specimens, obtained from the patients during tumor surgery from 2000 to 2005.
Potential target antigens for immunotherapy in human pancreatic cancer.
Heidelberg, Germany. In Cancer Lett, 2007
Tumor-associated antigen expression of MAGE-A1, MAGE-A3, MAGE-A4, MAGE-A10, LAGE-1, NY-ESO-1, SCP-1, SSX-2, SSX-4 and HERV-K-MEL was assessed by PCR.