gopubmed logo
find other proteinsAll proteins
GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Dec 2016.

Somatostatin receptor 5

SSTR5, sst5, somatostatin receptor subtype 5, Somato, somatostatin receptor 5
Somatostatin and its related peptide cortistatin exert multiple biological actions on normal and tumoral tissue targets by interacting with somatostatin receptors (SSTRs). The protein encoded by this gene is one of the SSTRs, which is a multi-pass membrane protein and belongs to the G-protein coupled receptor 1 family. The activity of this receptor is mediated by G proteins which inhibit adenylyl cyclase, and different regions of this receptor molecule are required for the activation of different signaling pathways. A mutation in this gene results in somatostatin analog resistance. Alternatively spliced transcript variants have been identified in this gene.[provided by RefSeq, Feb 2010] (from NCBI)
Top mentioned proteins: somatostatin, SSTR2, somatostatin receptor, CAN, SSTR4
Papers using SSTR5 antibodies
Connexin 43 mimetic peptide Gap27 reveals potential differences in the role of Cx43 in wound repair between diabetic and non-diabetic cells.
Hotchin Neil A., In PLoS ONE, 2009
... SSTR agonists (sst2: L-779,976, sst3: L-796,778, sst4: L-803,087 and sst5/1: L-817,818) were obtained from Merck Research Laboratories (Rahway, New ...
Papers on SSTR5
Somato stimulation and acupuncture therapy.
Zhu et al., Beijing, China. In Chin J Integr Med, Feb 2016
UNASSIGNED: Acupuncture is an oldest somato stimulus medical technique.
Dynamic mass redistribution reveals diverging importance of PDZ-ligands for G protein-coupled receptor pharmacodynamics.
Hague et al., Seattle, United States. In Pharmacol Res, Feb 2016
Pasireotide for malignant insulinoma.
Shimon et al., In Hormones (athens), Feb 2016
Pasireotide is a multi-receptor targeted somatostatin-analog with improved affinity for SSTR5.
Presence of sst5TMD4, a truncated splice variant of the somatostatin receptor subtype 5, is associated to features of increased aggressiveness in pancreatic neuroendocrine tumors.
Castaño et al., Madrid, Spain. In Oncotarget, Jan 2016
PURPOSE: Gastroenteropancreatic neuroendocrine tumors (GEP-NETs) are rare and heterogeneous tumors, and their biological behavior is not well known.
Expression profiles of somatostatin, dopamine, and estrogen receptors in pituitary adenomas determined by means of synthetic multilocus calibrators.
Cap et al., Hradec Králové, Czech Republic. In Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub, Dec 2015
The aim of the study was to determine the complete expression profiles of somatostatin receptors (SSTR1-SSTR5), dopamine receptors type 2 (D2R), and estrogen receptors (ER1) in various types of PA.
Somato-axodendritic release of oxytocin into the brain due to calcium amplification is essential for social memory.
Higashida, Kanazawa, Japan. In J Physiol Sci, Dec 2015
UNASSIGNED: Oxytocin (OT) is released into the brain from the cell soma, axons, and dendrites of neurosecretory cells in the hypothalamus.
[Comparison of early clinical effects between Activ C cervical disc replacement and anterior cervical discectomy and fusion for single-level cervical spondylosis].
Li et al., In Zhongguo Gu Shang, Nov 2015
Somato-score and psycho-score of SF-36 of two groups were obviously increased (P<0.05),
Expression of somatostatin receptors (SSTR1-SSTR5) in meningiomas and its clinicopathological significance.
Oliveira et al., Rio Grande, Brazil. In Int J Clin Exp Pathol, 2014
We investigated the immunohistochemical expression of five SSTR subtypes (SSTR1-SSTR5) in tumor tissue sections from 60 patients with diagnosis of meningioma who underwent surgical resection and relating it to patient age and sex, tumor histology, location, regrowth/recurrence and follow-up.
Filamin A in somatostatin and dopamine receptor regulation in pituitary and the role of cAMP/PKA dependent phosphorylation.
Mantovani et al., Milano, Italy. In Horm Metab Res, 2014
Resistance has been associated with defective expression of functional somatostatin and dopamine receptors SSTR2, SSTR5, and DRD2, respectively.
Cortical HCN channels: function, trafficking and plasticity.
Shah, London, United Kingdom. In J Physiol, 2014
Somato-dendritic HCN channels in pyramidal neurons modulate spike firing and synaptic potential integration by influencing the membrane resistance and resting membrane potential.
Somato-motor inhibitory processing in humans: evidence from neurophysiology and neuroimaging.
Kakigi et al., Nara, Japan. In J Physiol Sci, 2014
We mainly reviewed research on somato-motor inhibitory processing based on data obtained by using these techniques, which can examine 'when', 'where, and 'how' motor inhibition occurs in the brain.
Down-regulation of pancreatic and duodenal homeobox-1 by somatostatin receptor subtype 5: a novel mechanism for inhibition of cellular proliferation and insulin secretion by somatostatin.
Brunicardi et al., Los Angeles, United States. In Front Physiol, 2013
SSTR5 is one of the major SSTRs in the islets of Langerhans.
Expression of Ki-67, PTTG1, FGFR4, and SSTR 2, 3, and 5 in nonfunctioning pituitary adenomas: a high throughput TMA, immunohistochemical study.
Mercado et al., Mexico. In J Clin Endocrinol Metab, 2012
Determination of the expression of SSTR5 in an attempt to establish correlations and/or associations with clinical characteristics of patients with nonfunctioning pituitary adenomas.
Identification of somatostatin receptor type 5 gene polymorphisms associated with acromegaly.
Klovins et al., Rīga, Latvia. In Eur J Endocrinol, 2011
Our results demonstrate a previously undetected strong association of two SSTR5 single nucleotide polymorphisms with acromegaly
Somatostatin receptor 5 is palmitoylated by the interacting ZDHHC5 palmitoyltransferase.
Kreienkamp et al., Hamburg, Germany. In Febs Lett, 2011
ZDHHC5 and SSTR5 are colocalized at the plasma membrane and coexpression of ZDHHC5 increased palmitoylation of SSTR5 whereas knock-down of endogenous ZDHHC5 by siRNAs decreased it.
Somatostatin receptor 1 and 5 double knockout mice mimic neurochemical changes of Huntington's disease transgenic mice.
Kumar et al., Vancouver, Canada. In Plos One, 2010
SST and SSTRs might play an important role in regulation of neurodegeneration
Reassessment of sst(5) somatostatin receptor expression in normal and neoplastic human tissues using the novel rabbit monoclonal antibody UMB-4.
Schulz et al., Jena, Germany. In Neuroendocrinology, 2010
The rabbit monoclonal antibodies UMB-4 and UMB-1 will facilitate the assessment of the somatostatin receptor status of human tumors during routine histopathological examinations.
Indium-111-pentetreotide scintigraphy and somatostatin receptor subtype 2 expression: new prognostic factors for malignant well-differentiated endocrine tumors.
Buscail et al., Toulouse, France. In J Clin Oncol, 2008
Overall survival and expression of sst1 to sst5 receptors by immunohistochemistry were assessed.
Molecular mechanisms and therapeutical implications of intramembrane receptor/receptor interactions among heptahelical receptors with examples from the striatopallidal GABA neurons.
Fuxe et al., Stockholm, Sweden. In Pharmacol Rev, 2003
Heteromerization was also discovered among distinct types of G protein-coupled receptors with the initial demonstration of somatostatin SSTR5/dopamine D2 and adenosine A1/dopamine D1 heteromeric receptor complexes.
Receptors for dopamine and somatostatin: formation of hetero-oligomers with enhanced functional activity.
Patel et al., Montréal, Canada. In Science, 2000
Here, we show that dopamine receptor D2R and somatostatin receptor SSTR5 interact physically through hetero-oligomerization to create a novel receptor with enhanced functional activity.
share on facebooktweetadd +1mail to friends