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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Dec 2016.

SUMO1/sentrin specific peptidase 7

The reversible posttranslational modification of proteins by the addition of small ubiquitin-like SUMO proteins (see SUMO1; MIM 601912) is required for many cellular processes. SUMO-specific proteases, such as SENP7, process SUMO precursors to generate a C-terminal diglycine motif required for the conjugation reaction. They also display isopeptidase activity for deconjugation of SUMO-conjugated substrates (Lima and Reverter, 2008 [PubMed 18799455]).[supplied by OMIM, Jun 2009] (from NCBI)
Top mentioned proteins: Smt3, ACID, CAN, Ubiquitin, HAD
Papers on SSP2
SPOP E3 Ubiquitin Ligase Adaptor Promotes Cellular Senescence by Degrading the SENP7 deSUMOylase.
Zhang et al., Philadelphia, United States. In Cell Rep, Dec 2015
Here, we show that SPOP promotes senescence, an important tumor suppression mechanism, by targeting the SENP7 deSUMOylase for degradation.
Autophosphorylation of the Smk1 MAPK is spatially and temporally regulated by Ssp2 during meiotic development in yeast.
Winter et al., Philadelphia, United States. In Mol Biol Cell, Nov 2015
The Y is autophosphorylated in an intramolecular reaction that requires a meiosis-specific protein named Ssp2.
Purification and Initial Functions of Sex-Specific Storage Protein 2 in Bombyx mori.
Zhang et al., Hangzhou, China. In Protein J, Aug 2015
In this study, we identified a heat-resistant protein from the chrysalis stage of the silkworm which we named sex-specific storage protein 2 (SSP2).
The SENP7 SUMO-Protease Presents a Module of Two HP1 Interaction Motifs that Locks HP1 Protein at Pericentric Heterochromatin.
Quivy et al., Paris, France. In Cell Rep, Mar 2015
While H3K9me3 is thought to be a major contributor to HP1 enrichment at pericentric domains, in mouse cells, the SUMO-protease SENP7 is required in addition to H3K9me3.
c-Myc is targeted to the proteasome for degradation in a SUMOylation-dependent manner, regulated by PIAS1, SENP7 and RNF4.
Vertegaal et al., Leiden, Netherlands. In Cell Cycle, 2014
Increased SUMOylation of c-Myc was noted upon knockdown of the SUMO protease SENP7, indicating that it also could regulate a multi-SUMOylated protein in addition to poly-SUMOylated proteins.
Differential T-cell responses of semi-immune and susceptible malaria subjects to in silico predicted and synthetic peptides of Plasmodium falciparum.
Titanji et al., Bua Yai, Thailand. In Acta Trop, 2014
Of the 19 proteins studied, two were known vaccine candidates (MSP-8 and SSP2/TRAP), which reacted both with SIS and FSS.
Structural insights into the SENP6 Loop1 structure in complex with SUMO2.
Reverter et al., Barcelona, Spain. In Protein Sci, 2014
SENP6 and SENP7 are the most divergent members of the SENP/ULP protease family in humans by the presence of insertions in their catalytic domains.
The deSUMOylase SENP7 promotes chromatin relaxation for homologous recombination DNA repair.
Morris et al., Birmingham, United Kingdom. In Embo Rep, 2013
Here, we show that the SUMO/Sentrin/Smt3-specific peptidase, SENP7, interacts with the chromatin repressive KRAB-associated protein 1 (KAP1) through heterochromatin protein 1 alpha (HP1α).
Structures and transition states of Ge2CH2.
Schaefer et al., Athens, United States. In J Phys Chem A, 2013
Among them, seven structures are minima (1S-7S), two are transition states (TS1 and TS2), and two are second-order saddle points (SSP1 and SSP2).
New fluorescent probes for sulfane sulfurs and the application in bioimaging.
Xian et al., Pullman, United States. In Chem Sci, 2013
Based on this reaction, two fluorescent probes (SSP1 and SSP2) for the detection of sulfane sulfur species (persulfide, polysulfide, and elemental sulfur) were prepared and evaluated.
Swapping small ubiquitin-like modifier (SUMO) isoform specificity of SUMO proteases SENP6 and SENP7.
Reverter et al., Barcelona, Spain. In J Biol Chem, 2011
Loop 1 insertion in SENP6 and SENP7 as a platform to discriminate between SUMO1 and SUMO2/3 isoforms in this subclass of the SUMO protease family.
FRET-based in vitro assays for the analysis of SUMO protease activities.
Hay et al., Dundee, United Kingdom. In Methods Mol Biol, 2008
In humans cells three SUMO paralogues (SUMO-1, SUMO-2 and SUMO-3) and six SUMO specific proteases (SENP1-SENP3 and SENP5-SENP7) are expressed.
Structure of the human SENP7 catalytic domain and poly-SUMO deconjugation activities for SENP6 and SENP7.
Reverter et al., New York City, United States. In J Biol Chem, 2008
SENP6 and SENP7 exhibit lower rates for processing pre-SUMO1, pre-SUMO2, or pre-SUMO3 in comparison with SENP2
Malaria vaccines: are we getting closer?
Richie et al., Silver Spring, United States. In Curr Opin Mol Ther, 2007
This review highlights the most recent test-of-concept studies involving subunit vaccines; to illustrate this field of research, five antigens--CSP, TRAP/SSP2, LSA1, MSP1 and AMA1--are discussed.
Sporophytic self-incompatibility in Senecio squalidus L (Asteraceae)--the search for S.
Brennan et al., Bristol, United Kingdom. In J Exp Bot, 2003
Stigma-specific proteins associated with the S(1) allele and the S(2) allele have been identified using isoelectric focusing and these proteins have been designated SSP1 (Stigma S-associated Protein 1) and SSP2.
The malaria sporozoite's journey into the liver.
Sinnis, New York City, United States. In Infect Agents Dis, 1996
TRAP or SSP2, found on the parasite surface and in micronemes, binds to hepatocytes in a similar pattern as CS protein.
Protection against malaria by vaccination with sporozoite surface protein 2 plus CS protein.
Hoffman et al., Bethesda, United States. In Science, 1991
BALB/c mice immunized with irradiated Plasmodium yoelii sporozoites produced antibodies and cytotoxic T cells against a 140-kilodalton protein, sporozoite surface protein 2 (SSP2).
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