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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Dec 2016.

Slingshot homolog 1

SSH1, Slingshot, Ssh1p, SSHI, SSH1L
The protein encoded by this gene belongs to the slingshot homolog (SSH) family of phosphatases, which regulate actin filament dynamics. The SSH proteins dephosphorylate and activate the actin binding/depolymerizing factor cofilin, which subsequently binds to actin filaments and stimulates their disassembly. Cofilin is inactivated by kinases such as LIM domain kinase-1 (LIMK1), which may also be dephosphorylated and inactivated by SSH proteins. The SSH family thus appears to play a role in actin dynamics by reactivating cofilin proteins. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Aug 2011] (from NCBI)
Top mentioned proteins: cofilin, Actin, V1a, LIM, LIMK1
Papers on SSH1
Reorganization of actin filaments by ADF/cofilin is involved in formation of microtubule structures during Xenopus oocyte maturation.
Abe et al., Chiba, Japan. In Mol Biol Cell, Jan 2016
Immediately after GVBD, both Xenopus ADF/cofilin (XAC) and its phosphatase Slingshot (XSSH) accumulated into the nuclei and intranuclear actin filaments disassembled from the vegetal side with the shrinkage of the GV.
Identification of para-Substituted Benzoic Acid Derivatives as Potent Inhibitors of the Protein Phosphatase Slingshot.
Sun et al., Jinan, China. In Chemmedchem, Dec 2015
Slingshot proteins form a small group of dual-specific phosphatases that modulate cytoskeleton dynamics through dephosphorylation of cofilin and Lim kinases (LIMK).
Abnormal mechanosensing and cofilin activation promote the progression of ascending aortic aneurysms in mice.
Yanagisawa et al., Dallas, United States. In Sci Signal, Nov 2015
At P14, the actin depolymerizing factor cofilin was dephosphorylated and thus activated, and at P7, the abundance of slingshot-1 (SSH1) phosphatase, an activator of cofilin, was increased, leading to actin cytoskeletal remodeling.
Cofilin phosphorylation is elevated after F-actin disassembly induced by Rac1 depletion.
Liu et al., Xi'an, China. In Biofactors, Oct 2015
In the epidermis of mice in which Rac1 was knocked out only in keratinocytes, cofilin phosphorylation was aberrantly elevated, corresponding to repression of the phosphatase slingshot1 (SSH1).
Nox4-dependent activation of cofilin mediates VSMC reorientation in response to cyclic stretching.
San Martín et al., Atlanta, United States. In Free Radic Biol Med, Aug 2015
Cofilin, a protein that controls actin dynamics, is activated by Slingshot phosphatase-dependent serine 3 dephosphorylation by redox-dependent mechanisms.
Slingshot-Cofilin activation mediates mitochondrial and synaptic dysfunction via Aβ ligation to β1-integrin conformers.
Kang et al., In Cell Death Differ, Jun 2015
Correction to: Cell Death and Differentiation (2015) 22, 921–934; doi:10.1038/cdd.2015.5;
The yeast ERAD-C ubiquitin ligase Doa10 recognizes an intramembrane degron.
Kreft et al., Konstanz, Germany. In J Cell Biol, May 2015
Sbh2 is part of the trimeric Ssh1 complex involved in protein translocation.
WISp39 binds phosphorylated Coronin 1B to regulate Arp2/3 localization and Cofilin-dependent motility.
Fotedar et al., San Diego, United States. In J Cell Biol, Apr 2015
WISp39 preferentially interacts with phosphorylated Coronin 1B, allowing it to complex with Slingshot phosphatase (SSH) to dephosphorylate and activate Cofilin.
RanBP9 at the intersection between cofilin and Aβ pathologies: rescue of neurodegenerative changes by RanBP9 reduction.
Kang et al., Tampa, United States. In Cell Death Dis, 2014
Translocation of cofilin to mitochondria and induction of cofilin-actin pathology require the activation/dephosphorylation of cofilin by Slingshot homolog 1 (SSH1) and cysteine oxidation of cofilin.
Caspase-11 and caspase-1 differentially modulate actin polymerization via RhoA and Slingshot proteins to promote bacterial clearance.
Amer et al., Columbus, United States. In Sci Rep, 2014
Caspase-11 targets cofilin via the RhoA GTPase, whereas caspase-1 engages the Slingshot phosphatase.
Neuron navigator 2 overexpression indicates poor prognosis of colorectal cancer and promotes invasion through the SSH1L/cofilin-1 pathway.
Pei et al., Changsha, China. In J Exp Clin Cancer Res, 2014
In vitro and in vivo assays demonstrated that knockdown of NAV2 led to reduced migration and invasion of cancer cells, and the process involved the regulation of F-actin polymerization through the SSH1L/cofilin-1 pathway.
EphA signaling promotes actin-based dendritic spine remodeling through slingshot phosphatase.
Murai et al., Montréal, Canada. In J Biol Chem, 2012
EphA signaling promotes actin-based dendritic spine remodeling through slingshot 1.
Slingshot isoform-specific regulation of cofilin-mediated vascular smooth muscle cell migration and neointima formation.
Weber et al., Mobile, United States. In Arterioscler Thromb Vasc Biol, 2011
The regulation of VSMC migration by cofilin is SSH1 dependent and that this mechanism potentially contributes to neointima formation following vascular injury in vivo.
Platelet-derived growth factor (PDGF) regulates Slingshot phosphatase activity via Nox1-dependent auto-dephosphorylation of serine 834 in vascular smooth muscle cells.
San Martín et al., Atlanta, United States. In J Biol Chem, 2011
PDGF activates SSH1L in VSMC by a mechanism that involves Nox1-mediated oxidation of 14-3-3 and Ser-834 SSH1L auto-dephosphorylation.
Differentiation of human mesenchymal stem cells: the potential mechanism for estrogen-induced preferential osteoblast versus adipocyte differentiation.
Wang et al., Changchun, China. In Am J Med Sci, 2011
Results show the significance of SSH1L in estrogen-induced osteoblastogenic differentiation in favor of adipogenic differentiation from hMSCs.
Phosphorylation of Ser 402 impedes phosphatase activity of slingshot 1.
Hausser et al., Stuttgart, Germany. In Embo Rep, 2011
identified Ser 402 as a new phosphorylation site within the catalytic domain of human slingshot 1 (SSH1).
Protein kinase D1 regulates cofilin-mediated F-actin reorganization and cell motility through slingshot.
Storz et al., Jacksonville, United States. In Nat Cell Biol, 2009
Cofilin is activated by dephosphorylation through phosphatases of the slingshot (SSH) family.
Coronin 1B coordinates Arp2/3 complex and cofilin activities at the leading edge.
Bear et al., Chapel Hill, United States. In Cell, 2007
We report that Coronin 1B interacts simultaneously with Arp2/3 complex and Slingshot (SSH1L) phosphatase, two regulators of actin filament formation and turnover, respectively.
Cofilin phosphatases and regulation of actin dynamics.
Bokoch et al., Los Angeles, United States. In Curr Opin Cell Biol, 2006
To date, two cofilin-specific phosphatases have been identified: Slingshot and Chronophin.
Control of actin reorganization by Slingshot, a family of phosphatases that dephosphorylate ADF/cofilin.
Uemura et al., Kyoto, Japan. In Cell, 2002
Here we report Slingshot (SSH), a family of phosphatases that have the property of F actin binding.
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