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Single-stranded DNA binding protein 2

SSBP2 is a subunit of a single-stranded DNA (ssDNA)-binding complex involved in the maintenance of genome stability (Huang et al., 2009) [PubMed 19683501].[supplied by OMIM, Feb 2010] (from NCBI)
Top mentioned proteins: Ldb1, CAN, LIM, HAD, SSDP
Papers on SSBP2
Clinical and biological significance of de novo CD5+ diffuse large B-cell lymphoma in Western countries.
Young et al., Houston, United States. In Oncotarget, Apr 2015
CD5+ DLBCL was associated with higher frequencies of >1 ECOG performance status, bone marrow involvement, central nervous system relapse, activated B-cell-like subtype, Bcl-2 overexpression, and STAT3 and NF-κB activation, whereas rarely expressed single-stranded DNA-binding protein 2 (SSBP2), CD30 or had MYC mutations.
Global and gene-specific DNA methylation pattern discriminates cholecystitis from gallbladder cancer patients in Chile.
Guerrero-Preston et al., Baltimore, United States. In Future Oncol, 2014
RESULTS: Global DNA Methylation Index (p = 0.02) and promoter methylation of SSBP2 (p = 0.01) and ESR1 (p = 0.05) were significantly different in GBC when compared with cholecystitis.
A pilot genome-wide association study of breast cancer susceptibility loci in Indonesia.
Sari et al., Jakarta, Indonesia. In Asian Pac J Cancer Prev, 2014
P=6.88x10(-6)); chromosome 5q14.1 with the SSBP2 gene (OR=1.22,
Requirement for ssbp2 in hematopoietic stem cell maintenance and stress response.
Nagarajan et al., Houston, United States. In J Immunol, 2014
Sequence-specific ssDNA-binding protein 2 (SSBP2) is a candidate acute myelogenous leukemia (AML) suppressor gene located at chromosome 5q14.
GSTP1 promoter methylation is associated with recurrence in early stage prostate cancer.
Sidransky et al., Baltimore, United States. In J Urol, 2014
MATERIALS AND METHODS: We evaluated the extent of promoter methylation of genes previously reported as aberrantly methylated in prostate cancer (AIM1, APC, CCND2, GPX3, GSTP1, MCAM, RARβ2, SSBP2 and TIMP3) by quantitative fluorogenic methylation-specific polymerase chain reaction.
Application of SNP microarrays to the genome-wide analysis of chromosomal instability in premalignant airway lesions.
Geraci et al., Aurora, United States. In Cancer Prev Res (phila), 2014
Within these novel regions, losses of putative tumor suppressors (RNF20 and SSBP2) and an amplification of RASGRP3 gene with oncogenic activity were observed.
Genome-wide and gene-specific epigenomic platforms for hepatocellular carcinoma biomarker development trials.
Guerrero-Preston et al., Baltimore, United States. In Gastroenterol Res Pract, 2013
Promoter hypermethylation of RASSF1A, SSBP2, and B4GALT1 quantified by qMSP had a sensitivity ranging from 38% to 52%, a specificity of 100%, and an AUC from 0.58 to 0.75.
Genetic variants associated with protein C levels.
Bovill et al., Utrecht, Netherlands. In J Thromb Haemost, 2013
Next-generation sequencing of 113 candidate genes under the linkage peak revealed four SNPs in BHMT2, ACOT12, SSBP2 and XRCC4, which significantly increased PC levels in our thrombophilic family, but not in LETS.
Comprehensive analysis of transcriptome variation uncovers known and novel driver events in T-cell acute lymphoblastic leukemia.
Aerts et al., Leuven, Belgium. In Plos Genet, 2012
Finally, we detected gene fusions, of which several can explain the over-expression of key driver genes such as TLX1, PLAG1, LMO1, or NKX2-1; and others result in novel fusion transcripts encoding activated kinases (SSBP2-FER and TPM3-JAK2) or involving MLLT10.
Association of promoter methylation of VGF and PGP9.5 with ovarian cancer progression.
Hoque et al., Baltimore, United States. In Plos One, 2012
EXPERIMENTAL DESIGN: PH of PGP9.5, HIC1, AIM1, APC, PAK3, MGMT, KIF1A, CCNA1, ESR1, SSBP2, GSTP1, FKBP4 and VGF were assessed by quantitative methylation specific PCR (QMSP) in a training set.
Aberrant genes promoter methylation in neural crest-derived tumors.
Fazio et al., San Giovanni Rotondo, Italy. In Int J Biol Markers, 2012
We analyzed the promoter methylation status of 6 genes previously reported as cancer-specific methylated (MCAM, SSBP2, NISCH, B4GALT1, KIF1A and RASSF1A) in 38 neural crest-derived tumors by quantitative methylation-specific real-time PCR (QMSP).
SSBP2 variants are associated with survival in glioblastoma patients.
Wrensch et al., San Francisco, United States. In Clin Cancer Res, 2012
The minor allele of SSBP2 SNP rs17296479 and the increased tumor expression of SSBP2 were statistically significantly associated with poorer overall survival among glioblastoma patients
Gene expression in oligodendroglial tumors.
Walker et al., Liverpool, United Kingdom. In Cell Oncol (dordr), 2011
Novel genes associated with response to therapy included SSBP2, GFRA1, FAP and RASD1.
Cigarette smoke induces promoter methylation of single-stranded DNA-binding protein 2 in human esophageal squamous cell carcinoma.
Kim et al., Baltimore, United States. In Int J Cancer, 2011
results indicate that cigarette smoking is a cause of SSBP2 promoter methylation and that SSBP2 harbors a tumor suppressive role in ESCC through inhibition of the Wnt signaling pathway
Transcriptional profiling of peripheral blood mononuclear cells in pancreatic cancer patients identifies novel genes with potential diagnostic utility.
Batra et al., Omaha, United States. In Plos One, 2010
Unsupervised hierarchical clustering analysis identified an eight-gene predictor set, consisting of SSBP2, Ube2b-rs1, CA5B, F5, TBC1D8, ANXA3, ARG1, and ADAMTS20, that could distinguish PC patients from healthy controls with an accuracy of 79% in a blinded subset of samples from treatment naïve patients, giving a sensitivity of 83% and a specificity of 75%.
Differential gene expression analysis of peripheral blood mononuclear cells reveals novel test for early detection of pancreatic cancer.
Batra et al., Omaha, United States. In Cancer Biomark, 2010
PBMC expressions of six genes from our previous study (ANXA3, ARG1, CA5B, F5, SSBP2, and TBC1D8) along with four new genes (MIC1, NGAL, MUC1, and MUC16) were analyzed using multiplex Q-RT PCR.
Phosphorylation of the SSBP2 and ABL proteins by the ZNF198-FGFR1 fusion kinase seen in atypical myeloproliferative disorders as revealed by phosphopeptide-specific MS.
Cowell et al., Buffalo, United States. In Proteomics, 2009
ZNF198-FGFR1 is associated with phosphorylation of several proteins including SSBP2, ABL, FLJ14235, CALM and TRIM4 proteins.
Novel SSBP2-JAK2 fusion gene resulting from a t(5;9)(q14.1;p24.1) in pre-B acute lymphocytic leukemia.
Morton et al., Boston, United States. In Genes Chromosomes Cancer, 2008
SSBP2-JAK2 fusion gene resulting from a t(5;9)(q14.1;p24.1) is associated with pre-B acute lymphocytic leukemia.
ssDNA-binding protein 2 is frequently hypermethylated and suppresses cell growth in human prostate cancer.
Sidransky et al., Baltimore, United States. In Clin Cancer Res, 2008
SSBP2 inhibits prostate cancer cell proliferation and seems to represent a novel prostate cancer-specific DNA marker, especially in high stages of human prostate cancer.
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