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Splicing regulatory glutamine/lysine-rich protein 1

SRrp86, SFRS12, splicing factor, arginine/serine-rich 12, SRrp508, serine-arginine-rich splicing regulatory protein 86, DKFZp564B176
SFRS12 belongs to the superfamily of serine/arginine-rich (SR) splicing factors. It modulates splice site selection by regulating the activities of other SR proteins (Barnard et al., 2002 [PubMed 11991645]).[supplied by OMIM, Mar 2008] (from NCBI)
Top mentioned proteins: CAN, ACID, SRp20, SC35, fibrillin-1
Papers on SRrp86
Analysis of SRrp86-regulated alternative splicing: control of c-Jun and IκBβ activity.
Patton et al., Nashville, United States. In Rna Biol, 2010
From among the 500 splicing events exhibiting altered splicing under these conditions, the splicing of c-Jun and IkappaBbeta were validated as being regulated by SRrp86 resulting in altered regulation of their downstream targets.
[Changes of gene expression profile in homoharringtonine-induced leukemia multi-drug resistant cell line K562/HHT].
Chen et al., Jinan, China. In Zhonghua Xue Ye Xue Za Zhi, 2009
Four genes [NM-001721 (BMX), NM-031459 (SESN2), NM-033642 (FGF13) and AL-049309 (SFRS12)] expressed significantly differently in the two group cells, BMX gene expression was higher in K562/HHT, than in K562, but lower than in K562/HHT/RU486 as confirmed by RT-PCR and Western blot.
2-D PAGE-based comparison of proteasome inhibitor bortezomib in sensitive and resistant mantle cell lymphoma.
Dreyling et al., München, Germany. In Electrophoresis, 2009
All cell lines exhibited alterations of the cellular protein levels of heat shock-induced protein species (HSPA9, HSP7C, HSPA5, HSPD1), whereas sensitive cell lines also displayed altered cellular protein levels of energy metabolism (ATP5B, AK5, TPI1, ENO-1, ALDOC, GAPDH), RNA and transcriptional regulation (HNRPL, SFRS12) and cell division (NEBL, ACTB, SMC1A, C20orf23) as well as tumor suppressor genes (ENO-1, FH).
The splicing regulatory protein p18SRP is down-regulated in Alzheimer's disease brain.
Sawada et al., Suita, Japan. In J Mol Neurosci, 2003
p18SRP is a lysine-rich zinc finger domain-containing protein that interacts with the serine-arginine-rich splicing regulatory protein SRrp86; it is downregulated in brain of Alzheimer disease patients.
Regulation of alternative splicing by SRrp86 and its interacting proteins.
Patton et al., Nashville, United States. In Mol Cell Biol, 2003
SRrp86 is a unique member of the SR protein superfamily containing one RNA recognition motif and two serine-arginine (SR)-rich domains separated by an unusual glutamic acid-lysine (EK)-rich region.
A unique glutamic acid-lysine (EK) domain acts as a splicing inhibitor.
Patton et al., Nashville, United States. In J Biol Chem, 2002
the unique glutamic acid-lysine domain of SRrp86 plays a modulatory role controlling serine-arginine domain function
[Molecular cloning, characterization, chromosomal assignment, genomic organization and verification of SFRS12(SRrp508), a novel member of human SR protein superfamily and a human homolog of rat SRrp86].
Ma et al., Beijing, China. In Yi Chuan Xue Bao, 2002
The HGNC has just given SRrp508 gene entry the nomenclature information containing APPROVED SYMBOL: SFRS12; NAME: splicing factor, arginine/serine-rich 12; and ALIAS: DKFZp564B176, SRrp86.
Regulation of alternative splicing by SRrp86 through coactivation and repression of specific SR proteins.
Patton et al., Nashville, United States. In Rna, 2002
SRrp86 can activate SRp20 and repress SC35 in a dose-dependent manner both in vitro and in vivo
Identification and characterization of a novel serine-arginine-rich splicing regulatory protein.
Patton et al., Nashville, United States. In Mol Cell Biol, 2000
Because of the primary sequence and unique properties of p86, we have named this protein SRrp86 for SR-related protein of 86 kDa.
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