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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Dec 2016.

Spermidine synthase

SRM, spermidine synthase
The polyamines putrescine, spermine, and spermidine are ubiquitous polycationic mediators of cell growth and differentiation. Spermidine synthase is one of four enzymes in the polyamine-biosynthetic pathway and carries out the final step of spermidine biosynthesis. This enzyme catalyzes the conversion of putrescine to spermidine using decarboxylated S-adenosylmethionine as the cofactor. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: fibrillin-1, CAN, ACID, HAD, ESI
Papers using SRM antibodies
The PSI semantic validator: A framework to check MIAPE compliance of proteomics data
Martens Lennart et al., In Journal of Proteome Research, 2008
... Vendor-specific SRM assay file formats, including those from Thermo Scientific, Agilent, and ABI, are ...
Papers on SRM
Does Bilateral Experience Lead to Improved Spatial Unmasking of Speech in Children Who Use Bilateral Cochlear Implants?
Misurelli et al., Madison, United States. In Otol Neurotol, Feb 2016
Spatial release from masking (SRM) was quantified as the difference in SRTs between conditions with interferers at 0 degrees and 90 degrees.
Evaluation of steroidomics by liquid chromatography hyphenated to mass spectrometry as a powerful analytical strategy for measuring human steroid perturbations.
Rudaz et al., Genève, Switzerland. In J Chromatogr A, Feb 2016
Targeted LC-MS methods with selected reaction monitoring (SRM) were then introduced for quantifying a small steroid subset without the problems of cross-reactivity.
Moderate stress responses and specific changes in polyamine metabolism characterize Scots pine somatic embryogenesis.
Vuosku et al., Oulu, Finland. In Tree Physiol, Feb 2016
Cellular PA contents and the expression of the PA metabolism genes arginine decarboxylase (ADC), spermidine synthase (SPDS), thermospermine synthase (ACL5) and diamine oxidase (DAO) were analyzed, as well as the expression of catalase (CAT), DNA repair genes (RAD51, KU80) and autophagy-related genes (ATG5, ATG8) throughout the induction of somatic embryo formation in Scots pine SE cultures.
Behavioral and pharmacokinetic interactions between monoamine oxidase inhibitors and the hallucinogen 5-methoxy-N,N-dimethyltryptamine.
Halberstadt, San Diego, United States. In Pharmacol Biochem Behav, Feb 2016
The effects of MAO-A inhibition on the pharmacokinetics of 5-MeO-DMT and its metabolism to bufotenine were assessed using liquid chromatography-electrospray ionization-selective reaction monitoring-tandem mass spectrometry (LC-ESI-SRM-MS/MS).
Involvement of Heme Oxygenase-1 in particulate matter-induced impairment of NO-dependent relaxation in rat intralobar pulmonary arteries.
Courtois et al., Bordeaux, France. In Toxicol In Vitro, Feb 2016
The SRM-induced alteration of DEA-NO responsiveness was partially prevented by Cr (III) Mesoporphyrin IX Chloride.
Ultra-high sensitivity analysis of estrogens for special populations in serum and plasma by liquid chromatography-mass spectrometry: assay considerations and suggested practices.
Blair et al., Philadelphia, United States. In J Steroid Biochem Mol Biol, Feb 2016
Stable isotope dilution (SID) methodology coupled with liquid chromatography-selected reaction monitoring-mass spectrometry (LC-SRM/MS) is now accepted as the 'gold-standard' to quantify estrogens and their metabolites in serum and plasma due to improved specificity, high accuracy, and the ability to monitor multiple estrogens when compared with immunoassays.
Super-Resolution Microscopy: From Single Molecules to Supramolecular Assemblies.
Mennella et al., Toronto, Canada. In Trends Cell Biol, Dec 2015
Super-resolution microscopy (SRM) methods have allowed scientists to exceed the diffraction limit of light, enabling the discovery and investigation of cellular structures at the nanometer scale, from individual proteins to entire organelles.
Mass spectrometry (ms)-based translational proteomics for biomarker discovery and application in colorectal cancer.
Guo et al., Wuhan, China. In Proteomics Clin Appl, Dec 2015
Some new advances in the development of CRC protein markers, such as colorectal cancer stem cell related protein markers, selected and/or multiple reaction monitoring mass spectrometry (SRM/MRM-MS) and mass spectrometry cytometry (MSC) approaches are also discussed in order to address future directions and challenges from bench translational research to bedside clinical application of CRC biomarkers.
Detection of FGF15 in plasma by stable isotope standards and capture by anti-peptide antibodies and targeted mass spectrometry.
Mangelsdorf et al., Dallas, United States. In Cell Metab, Jul 2015
Here, we describe a stable isotope standards and capture by anti-peptide antibodies (SISCAPA) assay that combines immuno-enrichment with selected reaction monitoring (SRM) mass spectrometry to overcome this issue.
Development Rapid Analytical Methods for Inositol as a Trace Component by HPLC and LC-MS/MS in Infant Formula.
Kim et al., Seoul, South Korea. In Korean J Food Sci Anim Resour, 2014
Quantitative analysis was used for the detection limit test, infant formula recovery test, and standard reference material (SRM) 1849a to verify the validity of our LC-MS/MS analytical method, which was developed to quantify MI.
SRM/MRM targeted proteomics as a tool for biomarker validation and absolute quantification in human urine.
Zoidakis et al., Athens, Greece. In Expert Rev Mol Diagn, 2014
Urine has always been one of the most suitable body fluids for clinical applications.
Characterization of transgenic mice with overexpression of spermidine synthase.
Feith et al., United States. In Amino Acids, 2012
results indicate that SpdS levels are not rate limiting in vivo for polyamine biosynthesis and are unlikely to exert significant regulatory effects on cellular polyamine content and function
Selected reaction monitoring mass spectrometry reveals the dynamics of signaling through the GRB2 adaptor.
Pawson et al., Toronto, Canada. In Nat Biotechnol, 2011
To address this deficiency, we designed a mass spectrometry method, affinity purification-selected reaction monitoring (AP-SRM), which we used to comprehensively and quantitatively investigate changes in protein interactions with GRB2, an adaptor protein that participates in a remarkably diverse set of protein complexes involved in multiple aspects of cellular function.
A quantitative targeted proteomics approach to validate predicted microRNA targets in C. elegans.
Hengartner et al., Zürich, Switzerland. In Nat Methods, 2010
Using selected reaction monitoring (SRM), we quantified 161 proteins of interest in extracts from wild-type and let-7 mutant worms.
High-throughput generation of selected reaction-monitoring assays for proteins and proteomes.
Aebersold et al., Zürich, Switzerland. In Nat Methods, 2010
Selected reaction monitoring (SRM) uses sensitive and specific mass spectrometric assays to measure target analytes across multiple samples, but it has not been broadly applied in proteomics owing to the tedious assay development process for each protein.
Structure and mechanism of spermidine synthases.
Plotnikov et al., Toronto, Canada. In Biochemistry, 2007
Comparison of the structure of the human spermidine synthase with the known structure of T. maritima spermidine synthase provides a general mechanistic hypothesis for the aminopropyl transfer reaction.
Spermidine synthase is prominently expressed in the striatal patch compartment and in putative interneurones of the matrix compartment.
Laube et al., Berlin, Germany. In J Neurochem, 2006
The neuropil labelling in the patch compartment and in adjacent putative interneurones may indicate a role for polyamines in intercompartmental signalling in the striatum.
Coregulator function: a key to understanding tissue specificity of selective receptor modulators.
O'Malley et al., Houston, United States. In Endocr Rev, 2004
Selective receptor modulators (SRMs) are receptor ligands that exhibit agonistic or antagonistic biocharacter in a cell- and tissue context-dependent manner.
Brk, Srm, Frk, and Src42A form a distinct family of intracellular Src-like tyrosine kinases.
Tyner et al., Chicago, United States. In Oncol Res, 2002
The tyrosine kinases Brk/PTK6/Sik, Srm, Frk/Rak/Gtk/Iyk/Bsk, and Src42A/Dsrc41 have a low degree of sequence homology to other known kinases. The exon structure of these kinases, called the Brk family, is highly conserved and distinct.
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