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Squalene epoxidase

squalene epoxidase, Squalene Monooxygenase, SQLE
Squalene epoxidase catalyzes the first oxygenation step in sterol biosynthesis and is thought to be one of the rate-limiting enzymes in this pathway. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: ACID, CAN, HAD, STEP, demethylase
Papers on squalene epoxidase
Jasmonic acid and Methyl dihydrojasmonate enhance saponin biosynthesis as well as expression of functional genes in adventitious roots of Panax notoginseng F.H. Chen.
Gao et al., Tianjin, China. In Biotechnol Appl Biochem, Feb 2016
Furthermore, we found that JA and MDJ significantly up-regulated the expression of the geranyl diphosphate synthase (GPS), farnesyl diphosphate synthase (FPS), squalene synthase (SS), squalene epoxidase(SE), dammarenediol synthase (DS), CYP716A47 and CYP716A53v2 (CYP450 enzyme) genes, down-regulated the expression of the cycloartenol synthase (CAS) gene and increased superoxide dismutase (SOD), peroxidase (POD) activity.
Heterologous biosynthesis of triterpenoid dammarenediol-II in engineered Escherichia coli.
Lu et al., Tianjin, China. In Biotechnol Lett, Feb 2016
RESULTS: By the strategy of synthetic biology, dammarenediol-II biosynthetic pathway was reconstituted in E. coli by co-expression of squalene synthase (SS), squalene epoxidase (SE), NADPH-cytochrome P450 reductase (CPR) from Saccharomyces cerevisiae, and SE from Methylococcus capsulatus (McSE), NADPH-cytochrome P450 reductase (CPR) from Arabidopsis thaliana.
Increased lanosterol turnover: a metabolic burden for daunorubicin-resistant leukemia cells.
Nordström et al., Umeå, Sweden. In Med Oncol, Jan 2016
Treatment of CEM and CEM/R2 cells with cholesterol biosynthesis inhibitors acting on the enzymes squalene epoxidase and lanosterol synthase, both also involved in the 24,25-epoxycholesterol shunt pathway, revealed a connection of this pathway to lanosterol turnover.
Squalene is lipotoxic to yeast cells defective in lipid droplet biogenesis.
Hapala et al., In Biochem Biophys Res Commun, Jan 2016
Squalene levels in yeast are typically low but its accumulation can be induced under specific conditions, e.g. by inhibition of squalene monooxygenase with the antimycotic terbinafine.
Squalene epoxidase is a bona fide oncogene by amplification with clinical relevance in breast cancer.
Zoppoli et al., Genova, Italy. In Sci Rep, Dec 2015
SQLE encodes squalene epoxidase, a key enzyme in cholesterol synthesis.
Electron Transfer Pathways in Cholesterol Synthesis.
Porter, Lexington, United States. In Lipids, Oct 2015
Four enzymes catalyzing five steps in the pathway require electron input: squalene monooxygenase, lanosterol demethylase, sterol 4α-methyl oxidase, and sterol C5-desaturase.
Physiological feedback regulation of cholesterol biosynthesis: Role of translational control of hepatic HMG-CoA reductase and possible involvement of oxylanosterols.
Ness, Tampa, United States. In Biochim Biophys Acta, May 2015
Dietary cholesterol acts to significantly lower transcription of squalene epoxidase and lanosterol 14α demethylase favoring accumulation of the putative regulatory oxylanosterol-3β-hydroxylanosterol-8-en-32-al.
Lower Squalene Epoxidase and Higher Scavenger Receptor Class B Type 1 Protein Levels Are Involved in Reduced Serum Cholesterol Levels in Stroke-Prone Spontaneously Hypertensive Rats.
Mizutani et al., Fukuyama, Japan. In Biol Pharm Bull, 2014
When the mRNA levels of seven cholesterol biosynthetic enzymes were measured using real-time polymerase chain reaction (PCR), farnesyl pyrophosphate synthase and squalene epoxidase (SQE) levels in the liver of SHRSP were significantly lower than those in WKY.
Navigating the Shallows and Rapids of Cholesterol Synthesis Downstream of HMGCR.
Brown et al., Australia. In J Nutr Sci Vitaminol (tokyo), 2014
We also discuss the post-translational regulation of another critical enzyme, squalene monooxygenase (SM), which has its protein levels controlled by cholesterol, and DHCR24, which has its activity affected by sterols and related compounds, as well as via phosphorylation/signalling.
The UPS and downs of cholesterol homeostasis.
Brown et al., Sydney, Australia. In Trends Biochem Sci, 2014
This includes the low-density lipoprotein (LDL) receptor, transcription factors (sterol regulatory element binding proteins and liver X receptors), flux-controlling enzymes in cholesterol synthesis (3-hydroxy-3-methylglutaryl-CoA reductase and squalene monooxygenase), and cholesterol exporters (ATP-binding cassette transporters ABCA1 and ABCG1).
Expression and significance of squalene epoxidase in squamous lung cancerous tissues and pericarcinoma tissues.
Guo et al., Qingdao, China. In Thorac Cancer, 2014
BACKGROUND: A high expression of squalene epoxidase (SQLE) is related to tumor occurrence, development, and prognosis in a variety of cancers.
A suppressor screen in Mecp2 mutant mice implicates cholesterol metabolism in Rett syndrome.
Justice et al., Houston, United States. In Nat Genet, 2013
We show that a stop codon mutation in Sqle, encoding squalene epoxidase, a rate-limiting enzyme in cholesterol biosynthesis, underlies suppression in one line.
The biology and chemistry of antifungal agents: a review.
Gadhwe et al., Pune, India. In Bioorg Med Chem, 2012
This review addresses the areas such as the underlying mechanisms, eight different targets such as ergosterol synthesis, chitin synthesis, ergosterol disruptors, glucan synthesis, squalene epoxidase, nucleic acid synthesis, protein synthesis, microtubules synthesis.
Cholesterol-dependent degradation of squalene monooxygenase, a control point in cholesterol synthesis beyond HMG-CoA reductase.
Brown et al., Sydney, Australia. In Cell Metab, 2011
Squalene monooxygenase (SM) catalyzes the first oxygenation step in cholesterol synthesis, acting on squalene before cyclization into the basic steroid structure.
Squalene epoxidase, located on chromosome 8q24.1, is upregulated in 8q+ breast cancer and indicates poor clinical outcome in stage I and II disease.
Brandt et al., Stanford, United States. In Br J Cancer, 2008
Distant metastasis-free survival in stage I/II breast cancer cases was significantly inversely related to SQLE mRNA in multivariate Cox analysis in two independent patient cohorts of 160 patients each
Identification of genes differentially expressed in human primary lung squamous cell carcinoma.
Cheng et al., Beijing, China. In Lung Cancer, 2007
A cDNA library consisting of 220 upregulated genes in tumour tissue was established and named as LSCC. Differential expression was confirmed in five of these genes, including IGFBP5, SQLE, RAP2B, CLDN1, and TBL1XR1.
Hepatic cytochrome P450 reductase-null mice reveal a second microsomal reductase for squalene monooxygenase.
Porter et al., Lexington, United States. In Arch Biochem Biophys, 2007
Requires a redox partner, but cytochrome p450 reductase is not the only microsomal reductase that will serve this purpose.
Promoter analysis of the murine squalene epoxidase gene. Identification of a 205 bp homing region regulated by both SREBP'S and NF-Y.
Gåfvels et al., Stockholm, Sweden. In Biochim Biophys Acta, 2006
results demonstrate critical dependence of a 205 bp region for sterol dependent regulation of squalene epoxidase & uncover a possible framework for SREBP-promoter interaction, including a potent synergy with NF-Y that may be of principal importance.
Microarray gene expression analysis of the Fob3b obesity QTL identifies positional candidate gene Sqle and perturbed cholesterol and glycolysis pathways.
Horvat et al., Edinburgh, United Kingdom. In Physiol Genomics, 2005
Squalene epoxidase is a strong positional candidate gene for obesity, using squantitative trait locus studies.
Allylamine derivatives: new class of synthetic antifungal agents inhibiting fungal squalene epoxidase.
Stütz et al., In Science, 1984
SF 86-327 is a powerful specific inhibitor of fungal squalene epoxidase, a key enzyme in sterol biosynthesis.
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