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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Dec 2016.

Small proline-rich protein 3

SPRR3, Esophagin, small proline-rich protein 3
Top mentioned proteins: Involucrin, LOR, CAN, CagA, ACID
Papers on SPRR3
Quantitative Secretomic Analysis Identifies Extracellular Protein Factors that Modulate the Metastatic Phenotype of Non-Small Cell Lung Cancer.
Yu et al., In J Proteome Res, Feb 2016
RNA interference (RNAi)-mediated knock down of a number of these proteins, including SULT2B1, CEACAM5, SPRR3, AGR2, S100P and S100A14, leads to dramatically reduced migration of these cells.
The Genetics and Epigenetics of Atopic Dermatitis-Filaggrin and Other Polymorphisms.
Lu et al., Changsha, China. In Clin Rev Allergy Immunol, Oct 2015
Mutations in the human filaggrin gene (FLG) are the most significant and well-replicated genetic mutation associated with AD, and other mutations associated with epidermal barriers such as SPINK5, FLG-2, SPRR3, and CLDN1 have all been linked to AD. Gene variants may also contribute to the abnormal innate and adaptive responses found in AD, including mutations in PRRs and AMPs, TSLP and TSLPR, IL-1 family cytokines and receptors genes, vitamin D pathway genes, FCER1A, and Th2 and other cytokines genes.
Identification and evaluation of potential forensic marker proteins in vaginal fluid by liquid chromatography/mass spectrometry.
Sakurada et al., Okayama, Japan. In Anal Bioanal Chem, Sep 2015
We identified three components (average molecular mass values 17,237 ± 2, 18,063 ± 2, and 15,075 ± 1) detectable only in vaginal samples: two human small proline-rich protein 3 (SPRR3) isoforms and a human fatty acid-binding protein 5 (FABP5) with an acetylated (+42) N-terminal region lacking the initiator methionine residue (-131).
Identification of small proline-rich repeat protein 3 as a novel atheroprotective factor that promotes adaptive Akt signaling in vascular smooth muscle cells.
Young et al., Nashville, United States. In Arterioscler Thromb Vasc Biol, 2014
To this end, we have identified small proline-rich repeat protein (SPRR3) as selectively upregulated in vascular smooth muscle cells (VSMCs) of atheroma-bearing arterial tissue versus healthy arterial tissue.
Mechanisms of abnormal lamellar body secretion and the dysfunctional skin barrier in patients with atopic dermatitis.
Wakefield et al., San Francisco, United States. In J Allergy Clin Immunol, 2014
Although best known are mutations in filaggrin (FLG), mutations in other member of the fused S-100 family of proteins (ie, hornerin [hrn] and filaggrin 2 [flg-2]); the cornified envelope precursor (ie, SPRR3); mattrin, which is encoded by TMEM79 and regulates the assembly of lamellar bodies; SPINK5, which encodes the serine protease inhibitor lymphoepithelial Kazal-type trypsin inhibitor type 1; and the fatty acid transporter fatty acid transport protein 4 have all been linked to AD.
Expression of SPRR3 is associated with tumor cell proliferation and invasion in glioblastoma multiforme.
Zhang et al., Beijing, China. In Oncol Lett, 2014
Esophagin, also known as small proline-rich protein 3 (SPRR3), has been demonstrated to be important in the initiation and progression of numerous types of tumor, including colorectal and breast cancer.
Differentiation-associated genes regulated by c-Jun and decreased in the progression of esophageal squamous cell carcinoma.
Liu et al., Beijing, China. In Plos One, 2013
In this study, we found that c-Jun bound directly to the promoter region, and activated the transcription of differentiation-associated genes including cystatin A, involucrin and SPRR3 in vivo.
Small proline-rich repeat protein 3 enhances the sensitivity of esophageal cancer cells in response to DNA damage-induced apoptosis.
Liu et al., Beijing, China. In Mol Oncol, 2013
Small proline-rich repeat protein 3 (SPRR3) has been linked with the altered chemoradiosensitivity, however the underlying molecular mechanisms remain elusive.
Mesenchymal stem/progenitors and other endometrial cell types from women with polycystic ovary syndrome (PCOS) display inflammatory and oncogenic potential.
Giudice et al., San Francisco, United States. In J Clin Endocrinol Metab, 2013
Similarly, in eMSC(PCOS) vs eMSC(Ctrl), the most up-regulated genes were related to inflammation and cancer (IL-8, ICAM1, SPRR3, LCN2).
Statistical validation of the acceleration of the differentiation at the expense of the proliferation in human epidermal cells exposed to extremely low frequency electric fields.
Hinsenkamp et al., Brussels, Belgium. In Prog Biophys Mol Biol, 2013
In this list, genes such as DKK1, SPRR3, NDRG4, and CHEK1 are involved in cell proliferation or differentiation.
Expression of SPRR3 is associated with tumor cell proliferation in less advanced stages of breast cancer.
Cho et al., Seoul, South Korea. In Breast Cancer Res Treat, 2012
This study demonstrates that SPRR3 promotes BC cell proliferation by enhancing p53 degradation via the AKT and MAPK pathways
Combination of meta-analysis and graph clustering to identify prognostic markers of ESCC.
Wang et al., Shanghai, China. In Genet Mol Biol, 2012
The results showed that CXCL12, CYP2C9, TGM3, MAL, S100A9, EMP-1 and SPRR3 were highly associated with ESCC development.
DNA hypomethylation affects cancer-related biological functions and genes relevant in neuroblastoma pathogenesis.
Lavarino et al., Barcelona, Spain. In Plos One, 2011
Remarkably, such hypomethylation affected cancer-related biological functions and genes relevant to NB pathogenesis such as CCND1, SPRR3, BTC, EGF and FGF6.
Quantitative evaluation of SPRR3 expression in esophageal squamous cell carcinoma by qPCR and its potential use as a biomarker.
Albano et al., Rio de Janeiro, Brazil. In Exp Mol Pathol, 2011
The quantitative analysis of SPRR3 mRNA is a robust and reliable method to monitor the malignant transformation of the healthy esophageal mucosa into esophageal squamous cell carcinoma.
Association screening in the Epidermal Differentiation Complex (EDC) identifies an SPRR3 repeat number variant as a risk factor for eczema.
Lee et al., Berlin, Germany. In J Invest Dermatol, 2011
The SPRR3 variant associated with eczema carried an extra 24-bp repeat in the central domain, which may alter the physical properties of the cornified cell envelope
Characterization of two isoforms of human SPRR3 from saliva of preterm human newborn and autoptic fetal oral mucosa, parotid and submandibular gland samples.
Messana et al., Monserrato, Italy. In Biochem Biophys Res Commun, 2010
two isoforms of SPRR3 were characterized from saliva of preterm human newborn and autoptic fetal oral mucosa, parotid and submandibular gland samples.
Upregulation of SPRR3 promotes colorectal tumorigenesis.
Kim et al., Seoul, South Korea. In Mol Med, 2010
Results suggest that increased expression of SPRR3 is involved in colorectal tumorigenesis.
Identification of regulatory elements by gene family footprinting and in vivo analysis.
Backendorf et al., Leiden, Netherlands. In Adv Biochem Eng Biotechnol, 2006
Here we show the power of gene family footprinting by the identification of two novel elements in the SPRR3 promoter, not present in SPRR1A and SPRR2A.
Gene expression profiling of localized esophageal carcinomas: association with pathologic response to preoperative chemoradiation.
Ajani et al., Houston, United States. In J Clin Oncol, 2006
Using a combination marker approach, levels of PERP, S100A2, and SPRR3 allowed discrimination of pathCR from < pathCR with high sensitivity and specificity (85%).
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