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SPY putative UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase SPINDLY

Encodes a N-acetyl glucosamine transferase that may glycosylate other molecules involved in GA signaling. Contains a tetratricopeptide repeat region, and a novel carboxy-terminal region. SPY acts as both a repressor of GA responses and as a positive regulation of cytokinin signalling. SPY may be involved in reducing ROS accumulation in response to stress. (from NCBI)
Top mentioned proteins: CAN, HAD, ACID, V1a, ROD
Papers on SPINDLY
Whole-proteome genetic analysis of dependencies in assembly of a vertebrate kinetochore.
Earnshaw et al., Suita, Japan. In J Cell Biol, Jan 2016
Ndc80 associated with CENP-T interacts with a cohort of Rod, zw10, and zwilch (RZZ)-interacting proteins that includes Spindly, Mad1, and CENP-E.
Neoadjuvant Chemotherapy for Breast Cancer: Functional Tumor Volume by MR Imaging Predicts Recurrence-free Survival-Results from the ACRIN 6657/CALGB 150007 I-SPY 1 TRIAL.
ACRIN 6657 Trial Team and I-SPY 1 TRIAL Investigators et al., Georgetown, United States. In Radiology, Jan 2016
UNASSIGNED: Purpose To evaluate volumetric magnetic resonance (MR) imaging for predicting recurrence-free survival (RFS) after neoadjuvant chemotherapy (NACT) of breast cancer and to consider its predictive performance relative to pathologic complete response (PCR).
Cystathionine γ-lyase regulates arteriogenesis through NO-dependent monocyte recruitment.
Kevil et al., Shreveport, United States. In Cardiovasc Res, Oct 2015
METHODS AND RESULTS: Arteriogenesis including mature vessel density, collateral formation, blood flow, and SPY angiographic blush rate were determined in wild-type (WT) and CSE knockout (KO) mice at different time points following femoral artery ligation (FAL).
The Neoadjuvant Model Is Still the Future for Drug Development in Breast Cancer.
Esserman et al., Vancouver, Canada. In Clin Cancer Res, Aug 2015
The I-SPY 2/3 neoadjuvant trials exemplify this approach.
Preventing farnesylation of the dynein adaptor Spindly contributes to the mitotic defects caused by farnesyltransferase inhibitors.
Gassmann et al., Porto, Portugal. In Mol Biol Cell, Jun 2015
Here we identify the cytoplasmic dynein adaptor Spindly as an additional component of the outer kinetochore that is modified by farnesyltransferase (FTase).
A novel role of farnesylation in targeting a mitotic checkpoint protein, human Spindly, to kinetochores.
Chan et al., Edmonton, Canada. In J Cell Biol, Apr 2015
hSpindly KT localization is dependent on the RZZ complex and hSpindly recruits the dynein-dynactin complex to KTs during mitosis, but the mechanism of hSpindly KT recruitment is unknown.
Serial expression analysis of breast tumors during neoadjuvant chemotherapy reveals changes in cell cycle and immune pathways associated with recurrence and response.
van 't Veer et al., San Francisco, United States. In Breast Cancer Res, 2014
To elucidate the impact of NAC on the breast cancer transcriptome and its association with clinical outcome, we analyzed gene expression data derived from serial tumor samples of patients with breast cancer who received NAC in the I-SPY 1 TRIAL.
gigantea suppresses immutans variegation by interactions with cytokinin and gibberellin signaling pathways.
Rodermel et al., Ames, United States. In Plant Physiol, 2014
We show that the restoration of chloroplast biogenesis in imgi2 is caused by a development-specific derepression of cytokinin signaling that involves cross talk with signaling pathways mediated by gibberellin (GA) and SPINDLY (SPY), a GA response inhibitor.
SPINDLY, ERECTA, and its ligand STOMAGEN have a role in redox-mediated cortex proliferation in the Arabidopsis root.
Li et al., Tallahassee, United States. In Mol Plant, 2014
We here report that hydrogen peroxide induces cortex proliferation in the Arabidopsis root and that SPINDLY (SPY), an O-linked glucosamine acetyltransferase, regulates cortex proliferation by maintaining cellular redox homeostasis.
NO-binding in {Ru(NO)₂}⁸-type [Ru(NO)₂(PR₃)₂X]BF₄ compounds.
Klüfers et al., München, Germany. In Dalton Trans, 2014
The coordination entity's configuration in this subgroup is described by IUPAC's polyhedral symbol SPY-5.
Pretreatment vitamin D level and response to neoadjuvant chemotherapy in women with breast cancer on the I-SPY trial (CALGB 150007/150015/ACRIN6657).
I-SPY1 Investigators et al., Philadelphia, United States. In Cancer Med, 2014
Study patients (n = 82) were enrolled on the I-SPY TRIAL, had HER2-negative tumors, and available pretreatment serum.
Pathologic complete response predicts recurrence-free survival more effectively by cancer subset: results from the I-SPY 1 TRIAL--CALGB 150007/150012, ACRIN 6657.
Hylton et al., San Francisco, United States. In J Clin Oncol, 2012
The I-SPY 1 TRIAL (Investigation of Serial Studies to Predict Your Therapeutic Response With Imaging and Molecular Analysis) was a multicenter breast cancer study integrating clinical, imaging, and genomic data to evaluate pathologic response, RFS, and their relationship and predictability based on tumor biomarkers.
The Arabidopsis O-linked N-acetylglucosamine transferase SPINDLY interacts with class I TCPs to facilitate cytokinin responses in leaves and flowers.
Weiss et al., Jerusalem, Israel. In Plant Cell, 2012
Data suggest that responses of leaves and flowers to CK are mediated by SPY-dependent TCP14 and TCP15 activities.
Spindly switch controls anaphase: spindly and RZZ functions in chromosome attachment and mitotic checkpoint control.
Geley et al., Innsbruck, Austria. In Cell Cycle, 2011
Spindly is a coiled-coil domain containing protein, also known as CCDC99, that is an important regulator of the mitotic checkpoint.
Spindly/CCDC99 is required for efficient chromosome congression and mitotic checkpoint regulation.
Geley et al., Innsbruck, Austria. In Mol Biol Cell, 2010
Spindly is not only required for kinetochore localization of dynein but is a functional component of a mechanism that couples dynein-dependent poleward movement of chromosomes to their efficient attachment to microtubules.
Removal of Spindly from microtubule-attached kinetochores controls spindle checkpoint silencing in human cells.
Desai et al., San Diego, United States. In Genes Dev, 2010
dynein-mediated removal of Spindly from microtubule-attached kinetochores, rather than poleward transport per se, is the critical reaction in checkpoint silencing
O-GlcNAc protein modification in plants: Evolution and function.
Hartweck et al., Saint Paul, United States. In Biochim Biophys Acta, 2010
Phylogenetic analysis of eukaryotic O-GlcNAc transferases (OGTs) leads us to propose that plants have two distinct OGTs, SEC- and SPY-like, that originated in prokaryotes.
Regulators of the cytoplasmic dynein motor.
Vale et al., Cambridge, United States. In Nat Rev Mol Cell Biol, 2009
The answer could lie in the several multifunctional adaptors, including dynactin, lissencephaly 1, nuclear distribution protein E (NUDE) and NUDE-like, Bicaudal D, Rod-ZW10-Zwilch and Spindly, that regulate dynein function and localization.
Mitotic control of kinetochore-associated dynein and spindle orientation by human Spindly.
Santamaria et al., Martinsried, Germany. In J Cell Biol, 2009
[hSpindly] Localization of human Spindly (hSpindly) to kinetochores is controlled by the Rod/Zw10/Zwilch (RZZ) complex and Aurora B.
Cytosolic activity of SPINDLY implies the existence of a DELLA-independent gibberellin-response pathway.
Weiss et al., Jerusalem, Israel. In Plant J, 2009
SPY acts in the cytosol to suppress gibberellin responses and to promote cytokinin signaling.
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