The Mechanisms of M-cell Differentiation.
Yokohama, Japan. In Biosci Microbiota Food Health, 2013
We have found that the ets-family transcription factor Spi-B is essential for functional maturation of M cells.
Transcriptional control of dendritic cell differentiation.
Suita, Japan. In Curr Top Microbiol Immunol, 2013
We have recently found that an Ets family transcription factor, SPI-B, which is abundantly expressed in pDCs among DC subsets, plays critical roles in functions and late stage development of pDCs.
BATF-JUN is critical for IRF4-mediated transcription in T cells.
Bethesda, United States. In Nature, 2012
IRF4 binds DNA weakly owing to a carboxy-terminal auto-inhibitory domain, but cooperative binding with factors such as PU.1 or SPIB in B cells increases binding affinity, allowing IRF4 to regulate genes containing ETS-IRF composite elements (EICEs; 5'-GGAAnnGAAA-3').
ETS transcription factors and regulation of immunity.
Charleston, United States. In Arch Immunol Ther Exp (warsz), 2006
Of the 29 recognized ETS factors, nine are known to regulate genes involved in immunity, including Ets1, Ets2, GABP, Fli1, Elf1, MEF, ESE1, PU.1, and SpiB.