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Tubulin, gamma complex associated protein 2

Spc97p, GCP2, SPC97, hGCP2
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Top mentioned proteins: gamma-tubulin, GCP, carboxypeptidase, CAN, HAD
Papers on Spc97p
γ-Tubulin complex in Trypanosoma brucei: molecular composition, subunit interdependence and requirement for axonemal central pair protein assembly.
Li et al., Houston, United States. In Mol Microbiol, Nov 2015
Here we report that the γ-tubulin complex in T. brucei is composed of γ-tubulin and three GCP proteins, GCP2-GCP4, and is primarily localized in the basal body throughout the cell cycle.
Overexpression and Nucleolar Localization of γ-Tubulin Small Complex Proteins GCP2 and GCP3 in Glioblastoma.
Katsetos et al., Praha, Czech Republic. In J Neuropathol Exp Neurol, Jul 2015
The expression, cellular distribution, and subcellular sorting of the microtubule (MT)-nucleating γ-tubulin small complex (γTuSC) proteins, GCP2 and GCP3, were studied in human glioblastoma cell lines and in clinical tissue samples representing all histologic grades of adult diffuse astrocytic gliomas (n = 54).
Molecular modeling reveals binding interface of γ-tubulin with GCP4 and interactions with noscapinoids.
Naik et al., Solan, India. In Proteins, May 2015
The initiation of microtubule assembly within cells is guided by a cone shaped multi-protein complex, γ-tubulin ring complex (γTuRC) containing γ-tubulin and atleast five other γ-tubulin-complex proteins (GCPs), i.e., GCP2, GCP3, GCP4, GCP5, and GCP6.
Body mass index, physical activity, and serum markers of inflammation, immunity, and insulin resistance.
Shiels et al., Frederick, United States. In Cancer Epidemiol Biomarkers Prev, 2014
ORs and 95% confidence interval (CI) for highest versus lowest levels of CCL2/MCP-1, CXCL5/ENA-78, sTNFRII, CXCL10/IP-10, CXCL6/GCP2, CCL13/MCP-4, amylin, CRP, C-peptide, CCL19/MIP-3b, insulin, and leptin were: 1.50 (1.14-1.98),
Microtubule initiation from the nuclear surface controls cortical microtubule growth polarity and orientation in Arabidopsis thaliana.
Wasteneys et al., Vancouver, Canada. In Plant Cell Physiol, 2014
We used green fluorescent protein (GFP)-tagged gamma tubulin-complex protein 2 (GCP2) to identify nuclear MTOC activity and GFP-tagged End-Binding Protein 1b (EB1b) to track microtubule growth directions.
Activation of the γ-tubulin complex by the Mto1/2 complex.
Sawin et al., Edinburgh, United Kingdom. In Curr Biol, 2014
By direct imaging of individual Mto1/2[bonsai] complexes nucleating single microtubules in vivo, we further determine the number and stoichiometry of Mto1, Mto2, and γ-TuC subunits Alp4 (GCP2) and Alp6 (GCP3) within active nucleation complexes.
Functional replacement of fission yeast γ-tubulin small complex proteins Alp4 and Alp6 by human GCP2 and GCP3.
Paluh et al., Albany, United States. In J Cell Sci, 2013
We show genetically that GCP3/Spc98 function is fully conserved with Alp6 across species but that functional differences exist between GCP2/Spc97 and Alp4.
Fission yeast MOZART1/Mzt1 is an essential γ-tubulin complex component required for complex recruitment to the microtubule organizing center, but not its assembly.
Toda et al., Hiroshima, Japan. In Mol Biol Cell, 2013
Mzt1 is present in approximately equal stoichiometry with Alp4/GCP2 and localizes to all the MTOCs, including the SPB and interphase and equatorial MTOCs.
Genome-wide haploinsufficiency screen reveals a novel role for γ-TuSC in spindle organization and genome stability.
Basrai et al., Bethesda, United States. In Mol Biol Cell, 2013
This led to the identification of all three genes (SPC97, SPC98, and TUB4) encoding the evolutionarily conserved γ-tubulin small complex (γ-TuSC), which nucleates microtubule assembly.
Chromosome painting reveals multiple rearrangements between Gymnotus capanema and Gymnotus carapo (Gymnotidae, Gymnotiformes).
Ferguson-Smith et al., Belém, Brazil. In Cytogenet Genome Res, 2012
From these 4, GCA6 and GCA20 correspond to individual chromosomes (GCP8 and GCP15), while the other 2 share homology with parts of GCP1 and GCP2, respectively.
Arabidopsis GCP3-interacting protein 1/MOZART 1 is an integral component of the γ-tubulin-containing microtubule nucleating complex.
Hashimoto et al., Ikoma, Japan. In Plant J, 2012
GFP-GIP1a labeled mitotic microtubule arrays in a pattern largely consistent with, but partly distinct from, the localization of the γ-tubulin complex containing GCP2 or GCP3 in planta.
Molecular identification of β-citrylglutamate hydrolase as glutamate carboxypeptidase 3.
Van Schaftingen et al., Brussels, Belgium. In J Biol Chem, 2011
This behavior and the fact that the enzyme was glycosylated and membrane-bound suggested that β-citrylglutamate hydrolase belonged to the same family of protein as glutamate carboxypeptidase 2 (GCP2), the enzyme that catalyzes the hydrolysis of N-acetyl-aspartylglutamate.
Cell edges accumulate gamma tubulin complex components and nucleate microtubules following cytokinesis in Arabidopsis thaliana.
Wasteneys et al., Vancouver, Canada. In Plos One, 2010
gamma tubulin nucleation complex (GCP2 and GCP3) localize at distinct sites along the outer periclinal edge of newly formed crosswalls
Microtubule and katanin-dependent dynamics of microtubule nucleation complexes in the acentrosomal Arabidopsis cortical array.
Hashimoto et al., Ikoma, Japan. In Nat Cell Biol, 2010
We visualized the dynamics of two fluorescently-tagged γ-tubulin complex proteins, GCP2 and GCP3, in Arabidopsis thaliana.
A mutation in the Arabidopsis gamma-tubulin-containing complex causes helical growth and abnormal microtubule branching.
Hashimoto et al., Ikoma, Japan. In J Cell Sci, 2009
Results show that a null mutation of Arabidopsis GCP2, a core subunit of the gamma-tubulin-containing complex, severely impaired the development of male and female gametophytes.
Stability of the small gamma-tubulin complex requires HCA66, a protein of the centrosome and the nucleolus.
Merdes et al., Edinburgh, United Kingdom. In J Cell Sci, 2009
Stability of the small gamma-tubulin complex (gamma tubulin/GCP2/GCP3) requires HCA66, a protein of the centrosome and the nucleolus.
Genetic determinants of the homocysteine level.
Födinger et al., Vienna, Austria. In Kidney Int Suppl, 2003
Because Hcy metabolism is impaired in renal failure, MTHFR 677 C>T, GCP2 1561C>T, RFC1 80G>A, and TCN2 776G>C may further aggravate hyperhomocysteinemia in these patients.
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