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Serine threonine kinase 39

SPAK, PASK, PAS kinase, PASKIN, Ste20-like protein kinase
This gene encodes a serine/threonine kinase that is thought to function in the cellular stress response pathway. The kinase is activated in response to hypotonic stress, leading to phosphorylation of several cation-chloride-coupled cotransporters. The catalytically active kinase specifically activates the p38 MAP kinase pathway, and its interaction with p38 decreases upon cellular stress, suggesting that this kinase may serve as an intermediate in the response to cellular stress. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: PAK1, OSR1, WNK4, V1a, CAN
Papers using SPAK antibodies
Numerical Recipes. Cambridge: Cambridge University Press. 848 p
Huang Sui, In PLoS ONE, 1985
... and promoters were obtained from the following sources: Ptrc from pTrc99A (Amersham Biosciences); PtetA from pASK-IBA3 (Sigma Genosys); lacI from pTrc99A; tetR from pcDNA6/TR (Invitrogen); egfp from pEGFP (BD Biosciences Clontech); ...
Papers on SPAK
Kinase-KCC2 coupling: Cl- rheostasis, disease susceptibility, therapeutic target.
Delpire et al., Nashville, United States. In J Neurophysiol, Feb 2016
In this review, we propose that the functional and physical coupling of KCC2 to Cl(-)-sensitive kinase(s), such as the WNK1-SPAK kinase complex, constitutes a molecular "rheostat" that regulates [Cl(-)]i and thereby influences the functional plasticity of GABA.
Governing effect of regulatory proteins for Cl(-)/HCO3(-) exchanger 2 activity.
Hong et al., Inch'ŏn, South Korea. In Channels (austin), Jan 2016
The main goal of the present study was to investigate potential regulators, such as spinophilin (SPL), inositol-1,4,5-trisphosphate [IP3] receptors binding protein released with IP3 (IRBIT), STE20/S;PS1-related proline/a;lanine-rich kinase (SPAK) kinase, and carbonic anhydrase XII (CA XII).
Delineating PAS-HAMP interaction surfaces and signaling-associated changes in the aerotaxis receptor aer.
Taylor et al., Loma Linda, United States. In Mol Microbiol, Jan 2016
Inaccessible PAS-HAMP surfaces overlapped with a cluster of PAS kinase-on lesions and with cysteine substitutions that crosslinked the PAS β-scaffold to the HAMP AS-2 helix.
Arsenic acid inhibits proliferation of skin fibroblasts, and increases cellular senescence through ROS mediated MST1-FOXO signaling pathway.
Maruyama et al., Miyazaki, Japan. In J Toxicol Sci, Dec 2015
It also activated the mammalian Ste20-like protein kinase 1 (MST1); however the serine/threonine kinase Akt was downregulated.
Osmotic stress induces the phosphorylation of WNK4 Ser575 via the p38MAPK-MK pathway.
Naguro et al., Tokyo, Japan. In Sci Rep, Dec 2015
The With No lysine [K] (WNK)-Ste20-related proline/alanine-rich kinase (SPAK)/oxidative stress-responsive kinase 1 (OSR1) pathway has been reported to be a crucial signaling pathway for triggering pseudohypoaldosteronism type II (PHAII), an autosomal dominant hereditary disease that is characterized by hypertension.
Chronic Metabolic Acidosis Activates Renal Tubular Sodium Chloride Cotransporter through Angiotension II-dependent WNK4-SPAK Phosphorylation Pathway.
Lin et al., Taipei, Taiwan. In Sci Rep, Dec 2015
We examined the role of STE20/SPS1-related proline/alanine-rich kinase (SPAK) and with-no-lysine kinase 4 (WNK4) on expression of NCC in mouse models of CMA.
[WNK-SPAK-SLC12A signal cascade is a new therapeutic target for hypertension].
Uchida et al., In Nihon Rinsho, Sep 2015
WNK-oxidative stress-responsive 1 (OSR1) /STE20/SPS1-related proline-alanine-rich protein kinase(SPAK)-SLC12A transporters cascade regulates blood pressure through NaCl reabsorption in kidney and vasoconstriction.
Per-Arnt-Sim Kinase (PASK): An Emerging Regulator of Mammalian Glucose and Lipid Metabolism.
Li et al., Shanghai, China. In Nutrients, Sep 2015
Per-Arnt-Sim Kinase (PASK) is an evolutionarily-conserved nutrient-responsive protein kinase that regulates lipid and glucose metabolism, mitochondrial respiration, phosphorylation, and gene expression.
Kelch-like 3/Cullin 3 ubiquitin ligase complex and WNK signaling in salt-sensitive hypertension and electrolyte disorder.
Uchida et al., Tokyo, Japan. In Nephrol Dial Transplant, Aug 2015
Rigorous studies have demonstrated that WNK kinases constitute a signaling cascade with oxidative stress-responsive gene 1 (OSR1), Ste20-related proline-alanine-rich kinase (SPAK) and the solute carrier family 12a (SLC12a) transporter, including thiazide-sensitive NaCl cotransporter.
Development and regulation of chloride homeostasis in the central nervous system.
Fukuda et al., Hamamatsu, Japan. In Front Cell Neurosci, 2014
KCC2 and NKCC1 functions are also regulated by phosphorylation by enzymes such as PKC, Src-family tyrosine kinases, and WNK1-4 and their downstream effectors STE20/SPS1-related proline/alanine-rich kinase (SPAK)-oxidative stress responsive kinase-1 (OSR1).
Molecular physiology of SPAK and OSR1: two Ste20-related protein kinases regulating ion transport.
Delpire et al., Nashville, United States. In Physiol Rev, 2012
SPAK (Ste20-related proline alanine rich kinase) and OSR1 (oxidative stress responsive kinase) are members of the germinal center kinase VI subfamily of the mammalian Ste20 (Sterile20)-related protein kinase family.
PAS kinase: integrating nutrient sensing with nutrient partitioning.
Rutter et al., Salt Lake City, United States. In Semin Cell Dev Biol, 2012
These data strongly suggest that PASK is required for normal nutrient partitioning and energy homeostasis in the mouse and that this activity is primarily carried out in a cell-autonomous fashion.[Review]
Kinases SPAK and OSR1 are upregulated by estradiol and activate NKCC1 in the developing hypothalamus.
McCarthy et al., Baltimore, United States. In J Neurosci, 2012
SPAK and oxidative stress response kinase (OSR1) may be critical factors in the regulation of depolarizing GABA-mediated processes in the developing brain.
Human mutation within Per-Arnt-Sim (PAS) domain-containing protein kinase (PASK) causes basal insulin hypersecretion.
Rutter et al., London, United Kingdom. In J Biol Chem, 2012
Per-Arnt-Sim (PAS) domain-containing protein kinase (PASK) has a role in insulin hypersecretion
The calcineurin inhibitor tacrolimus activates the renal sodium chloride cotransporter to cause hypertension.
Ellison et al., Portland, United States. In Nat Med, 2011
In wild-type mice, the CNI tacrolimus caused salt-sensitive hypertension and increased the abundance of phosphorylated NCC and the NCC-regulatory kinases WNK3, WNK4 and SPAK.
A SPAK isoform switch modulates renal salt transport and blood pressure.
Ellison et al., Portland, United States. In Cell Metab, 2011
An emerging model suggests that bumetanide- and thiazide-sensitive NaCl transporters (NKCC2 and NCC) along these segments are phosphorylated and activated by WNK kinases, via SPAK and OSR1.
WNK1 regulates vasoconstriction and blood pressure response to α 1-adrenergic stimulation in mice.
Hadchouel et al., Paris, France. In Hypertension, 2011
Findings uncover a vascular signaling pathway linking alpha(1)-adrenergic receptors and pressure to WNK1, SPAK, and NKCC1 and may, thus, significantly broaden the comprehension of the regulatory mechanisms of vascular tone in arterial hypertension.
Complement regulator CD46 temporally regulates cytokine production by conventional and unconventional T cells.
Kemper et al., London, United Kingdom. In Nat Immunol, 2010
In this study we demonstrate a new form of immunoregulation: engagement on CD4(+) T cells of the complement regulator CD46 promoted the effector potential of T helper type 1 cells (T(H)1 cells), but as interleukin 2 (IL-2) accumulated, it switched cells toward a regulatory phenotype, attenuating IL-2 production via the transcriptional regulator ICER/CREM and upregulating IL-10 after interaction of the CD46 tail with the serine-threonine kinase SPAK.
The role of PAS kinase in PASsing the glucose signal.
Rutter et al., Provo, United States. In Sensors (basel), 2009
The role of PAS kinase in PASsing the glucose signal.
Molecular pathogenesis of pseudohypoaldosteronism type II: generation and analysis of a Wnk4(D561A/+) knockin mouse model.
Uchida et al., Tokyo, Japan. In Cell Metab, 2007
Increased phosphorylation of the kinases OSR1 and SPAK was also observed in the knockin mice.
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