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Trans-acting transcription factor 6

SP6 belongs to a family of transcription factors that contain 3 classical zinc finger DNA-binding domains consisting of a zinc atom tetrahedrally coordinated by 2 cysteines and 2 histidines (C2H2 motif). These transcription factors bind to GC-rich sequences and related GT and CACCC boxes (Scohy et al., 2000 [PubMed 11087666]).[supplied by OMIM, Mar 2008] (from NCBI)
Top mentioned proteins: CAN, HAD, ACID, OUT, fibrillin-1
Papers on Sp6
Effects of LI-4 and SP-6 Acupuncture on Labor Pain, Cortisol Level and Duration of Labor.
Kasraeian et al., Shīrāz, Iran. In J Acupunct Meridian Stud, Oct 2015
Acupuncture was performed at the SP-6 and the LI-4 points in the study group, and sham acupuncture was performed at the same points in the control group.
Effects of electro-acupuncture on labor pain management.
Zhang et al., Hangzhou, China. In Arch Gynecol Obstet, Mar 2015
METHODS: Nulliparous women under the maternity care of the Department of Obstetrics and Gynecology of Sir Run Run Shaw Hospital were recruited and allocated into two experimental groups (EX-B2 group and SP6 group) and one control group, each with 60 eligible participants.
Treatment of leptothrix cells with ultrapure water poses a threat to their viability.
Takada et al., Okayama, Japan. In Biology (basel), 2014
It was observed that L. discophora strain SP-6 cells also underwent autolysis when suspended in ultrapure water; it is however, uncertain whether this phenomenon is common among other members of the genus Leptothrix.
Identification of imidazoquinoline derivatives as potent antiglioma agents.
Miller et al., Memphis, United States. In Med Chem, 2014
With the aim of identifying new antiglioma agents we screened the UC DDC library for compounds structurally related to the antiglioma lead molecule compound 1 (SP-6-27) and clinically used compound 2 (Azixa).
Design, Synthesis and Biological Evaluation of Novel 5H-Chromenopyridines as Potential Anti-Cancer Agents.
Miller et al., Memphis, United States. In Molecules, 2014
Based on our initial lead SP-6-27 compound, we designed and synthesized novel tricyclic 5H-thiochromenopyridine and 5H-chromenopyridine analogs to evaluate the impact of an additional ring, as well as conformational flexibility on cytotoxic activity against human melanoma and glioma cell lines.
The Effect of Acupressure at GB-21 and SP-6 Acupoints on Anxiety Level and Maternal-Fetal Attachment in Primiparous Women: a Randomized Controlled Clinical Trial.
Hadianfard et al., Fasā, Iran. In Nurs Midwifery Stud, 2014
MATERIALS AND METHODS: In this study, 150 primiparous women were allocated to acupressure at GB-21 acupoint, acupressure at SP-6 acupoint, and control group.
The use of digital images improves reproducibility of the ki-67 labeling index as a proliferation marker in breast cancer.
Cserni et al., Szeged, Hungary. In Pathol Oncol Res, 2014
Thirty breast cancer core-biopsy samples were stained with B-56, SP-6 and MIB-1 monoclonal Ki-67 antibodies.
An innovative acupuncture treatment for primary dysmenorrhea: a randomized, crossover pilot study.
Gomolak et al., In Altern Ther Health Med, 2014
INTERVENTION: Women with primary dysmenorrhea were randomized into 2 groups to receive bilateral injections of vitamin K1 in the Spleen-6 (SP-6) acupuncture point at the start of menstruation and then, following a 2-mo washout period, saline in a nonacupuncture point at the start of menstruation.
The effect of acupressure on the level of fatigue in hemodialysis patients.
Taşci et al., In Altern Ther Health Med, 2013
INTERVENTIONS: A total of 12 acupressure sessions, 3 ×/wk for 1 mo, were performed for all participants in the intervention group, as required by the acupressure application protocol, applying acupressure at the Stomach 36 (ST-36), Gallbladder 34 (GB-34), Spleen 6 (SP-6), and Kidney 1 (K-1) acupuncture points with a transcutaneous electrical nerve stimulation (TENS) acupuncture pen (XFT-320 acupuncture pen, Shenzhen Xunfegtong Electronics Co, Ltd, Shenzhen, China).
Effects of acupuncture and electroacupuncture on estradiol-induced inflammation and oxidative stress in health rodents.
Guimarães et al., Fortaleza, Brazil. In Acta Cir Bras, 2013
The equivalent of the human right ST-36 (Zusanli) and SP-6 (Sanyinjiao) acupoints were chosen for needling and electrical stimulation.
Microscale gradients of oxygen, hydrogen peroxide, and pH in freshwater cathodic biofilms.
Beyenal et al., Pullman, United States. In Chemsuschem, 2013
We used laboratory river-water biofilms and pure culture biofilms of Leptothrix discophora SP-6 as two types of cathodic biofilms.
Acupuncture-evoked response in somatosensory and prefrontal cortices predicts immediate pain reduction in carpal tunnel syndrome.
Napadow et al., United States. In Evid Based Complement Alternat Med, 2012
Subjects were randomized to 3 groups: (1) EA applied at local acupoints on the affected wrist (PC-7 to TW-5), (2) EA at distal acupoints (contralateral ankle, SP-6 to LV-4), and (3) sham EA at nonacupoint locations on the affected wrist.
Dissection of morphological and metabolic differentiation of ameloblasts via ectopic SP6 expression.
Noma et al., Tokushima, Japan. In J Med Invest, 2011
Morphological differentiation and metabolism of the iron-containing pigment in ameloblasts are independently regulated during amelogenesis by means of ectopic SP6 expression.
Possible linkage of SP6 transcriptional activity with amelogenesis by protein stabilization.
Noma et al., Tokushima, Japan. In J Biomed Biotechnol, 2010
Findings suggest that the regulation of SP6 protein stability is one of the crucial steps in amelogenesis.
The effect of acupressure at the Sanyinjiao point (SP6) on primary dysmenorrhea in students resident in dormitories of Tabriz.
Majlesi et al., Tabrīz, Iran. In Iran J Nurs Midwifery Res, 2010
The present study aimed to determine the effect of acupressure at the Sanyinjiao point (SP-6) on severity of menstrual symptoms (primary outcome) and the duration of resting time as well as the number of ibuprofen consumption (secondary outcome) in the two types of primary dysmenorrhea.
Role of Epiprofin, a zinc-finger transcription factor, in limb development.
Ros et al., Santander, Spain. In Dev Biol, 2010
EPFN very likely functions as a modulator of WNT signaling in the limb ectoderm.
The development of several organs and appendages is impaired in mice lacking Sp6.
Szpirer et al., Charleroi, Belgium. In Dev Dyn, 2008
Data suggest that Sp6 plays a critical role in the development of several epithelium-containing organs or appendages, possibly by regulating apoptosis.
Sp6 downregulation of follistatin gene expression in ameloblasts.
Noma et al., Tokushima, Japan. In J Med Invest, 2008
Sp6 promotes amelogenesis through inhibition of follistatin gene expression.
Acupuncture use for pre-birth treatment. A literature review and audit-based research.
Don et al., Wellington, New Zealand. In Complement Ther Clin Pract, 2005
Traditionally acupuncture at four points, Yanglingquan GB-34, Zusanli ST-36, Sanyinjiao SP-6 and Zhiyin BL-67, has been used for pre-birth treatments (Maciocia and West (eds.),
Acupuncture for immune-mediated disorders. Literature review and clinical applications.
Limehouse et al., In Probl Vet Med, 1992
Immunostimulant points include LI-4, LI-11, ST-36, GB-39, SP-6, GV-14, BL-11, BL-20, BL-23, BL-24, BL-25, BL-26, BL-27, BL-28, and CV-12.
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