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Sp3 transcription factor

This gene belongs to a family of Sp1 related genes that encode transcription factors that regulate transcription by binding to consensus GC- and GT-box regulatory elements in target genes. This protein contains a zinc finger DNA-binding domain and several transactivation domains, and has been reported to function as a bifunctional transcription factor that either stimulates or represses the transcription of numerous genes. Transcript variants encoding different isoforms have been described for this gene, and one has been reported to initiate translation from a non-AUG (AUA) start codon. Additional isoforms, resulting from the use of alternate downstream translation initiation sites, have also been noted. A related pseudogene has been identified on chromosome 13. [provided by RefSeq, Feb 2010] (from NCBI)
Top mentioned proteins: V1a, CAN, SP1, ACID, STEP
Papers using Sp3 antibodies
Comparative analysis of six different antibodies against Her2 including the novel rabbit monoclonal antibody (SP3) and chromogenic in situ hybridisation in breast carcinomas
van de Vijver Marc J et al., In Breast Cancer Research : BCR, 2007
... Each donor block was stained with the antibodies SP3 (Labvision, using Labvision autostainer, Fremont, CA, United States), 4B5 (Ventana medical systems, using the Benchmark XT, ...
Cleavage of the serum response factor during death receptor-induced apoptosis results in an inhibition of the c-FOS promoter transcriptional activity.
Kudla Grzegorz, In PLoS ONE, 1999
... Anti-Myc antibody (9E10), Anti-Sp1 (PEP-2) and Sp3 (D 20) were from Santa Cruz Biotechnology (Santa Cruz, CA) ...
Papers on Sp3
DDQ-Promoted benzylic/allylic sp3 C-H activation for the stereoselective intramolecular C-N bond formation: Applications to the total synthesis of (-) codonopsinine, (+) 5-epi codonopsinine, (+) radicamine B and (-) codonopsinol.
Rao et al., In J Org Chem, Feb 2016
UNASSIGNED: This is the first report on an intramolecular C-N bond formation of amide tethered benzylic/allylic system using DDQ under neutral condition and it has been successfully applied to the total synthesis of naturally occurring pyrolidine alkaloids.
Aliphatic Halogenase Enables Late-Stage C-H Functionalization: Selective Synthesis of Brominated Fischerindole Alkaloid with Enhanced Antibacterial Activity.
Liu et al., Pittsburgh, United States. In Chembiochem, Feb 2016
UNASSIGNED: Anion promiscuity of a newly discovered standalone aliphatic halogenase WelO5 was probed and enabled the selective synthesis of 13R-bromo 12-epi-fischerindole U via late-stage enzymatic functionalization of unactivated sp3 C-H bond.
Stereoselective Synthesis of Diazabicyclic beta-Lactams through Intramolecular Amination of Unactivated C(sp3)-H Bonds of Carboxamides by Palladium Catalysis.
Wu et al., In J Org Chem, Feb 2016
UNASSIGNED: An efficient C(sp3)-H bonds activation and intramolecular amination reaction via Palladium catalysis at the beta-position of carboxyamides to make beta-lactams was described.
Synthesis of many different types of organic small molecules using one automated process.
Burke et al., Urbana, United States. In Science, Apr 2015
This was achieved by strategically expanding the scope of a building block-based synthesis platform to include even C(sp3)-rich polycyclic natural product frameworks and discovering a catch-and-release chromatographic purification protocol applicable to all of the corresponding intermediates.
Analysis of differentially expressed genes based on microarray data of glioma.
Zhou et al., Nanjing, China. In Int J Clin Exp Med, 2014
In addition, the transcription factor analysis showed these DEGs were regulated by the binding sites of transcription factors GLI2, SP1, SMAD7, SMAD3, RELA, STAT5B, CTNNB1, STAT5A, TFAP2A and SP3.
Antioxidant Activity of Allium hookeri Root Extract and Its Effect on Lipid Stability of Sulfur-fed Pork Patties.
Lee et al., Seoul, South Korea. In Korean J Food Sci Anim Resour, 2014
The 1% AHE (SP1), 3% AHE (SP2), and 0.05% ascorbic acid (SP3) were added into sulfur-fed pork patties against controls; SP0 (sulfur-fed pork patties with no AHE) and P0 (normal pork patties with no AHE).
Gold-catalyzed C(sp3)-H bond functionalization.
Zhu et al., Nanjing, China. In Chem Soc Rev, 2014
C-H bonds are ubiquitous in organic molecules.
Dual catalysis. Single-electron transmetalation in organoboron cross-coupling by photoredox/nickel dual catalysis.
Molander et al., Philadelphia, United States. In Science, 2014
The routine application of C(sp3)-hybridized nucleophiles in cross-coupling reactions remains an unsolved challenge in organic chemistry.
sp3-sp3 Coupling reactions in the synthesis of natural products and biologically active molecules.
Schmidt et al., Hannover, Germany. In Nat Prod Rep, 2014
This Highlight covers the current status of relatively unexplored sp(3)-sp(3) cross-coupling reactions with particular focus on natural product and related syntheses.
Pirfenidone: an update on clinical trial data and insights from everyday practice.
Kreuter, Heidelberg, Germany. In Eur Respir Rev, 2014
It was approved for the treatment of adults with mild-to-moderate idiopathic pulmonary fibrosis in the European Union based on the results of two pivotal phase III, double-blind, randomised, placebo-controlled clinical trials (CAPACITY) demonstrating efficacy and safety, and supported by two Japanese clinical trials (SP2 and SP3).
Ligand-enabled cross-coupling of C(sp3)-H bonds with arylboron reagents via Pd(II)/Pd(0) catalysis.
Yu et al., Los Angeles, United States. In Nat Chem, 2014
There have been numerous developments in C-H activation reactions in the past decade.
Brightening of carbon nanotube photoluminescence through the incorporation of sp3 defects.
Wang et al., College Park, United States. In Nat Chem, 2013
Semiconducting carbon nanotubes promise a broad range of potential applications in optoelectronics and imaging, but their photon-conversion efficiency is relatively low.
Sp1 and Sp3 are involved in the full transcriptional activity of centromere protein H in human nasopharyngeal carcinoma cells.
Zhang et al., Guangzhou, China. In Febs J, 2012
Sp1 and Sp3 bind to the CENPH minimal promoter and function as a regulator of the transcription of CENPH in nasopharyngeal carcinomas.
Transcription factors Sp1 and Sp3 regulate basal transcription of the human IRF-3 gene.
Zhou et al., Nanjing, China. In Biochimie, 2012
Overexpression of Sp1 and Sp3, but not NRF-1, transactivated the IRF-3 promoter activity in reporter gene assays while knocking-down of endogenous Sp1 and Sp3 by a shRNA strategy markedly inhibited IRF-3 promoter activity.
Regulatory mechanisms of the HB-EGF autocrine loop in inflammation, homeostasis, development and cancer.
Miyamoto et al., Fukuoka, Japan. In Anticancer Res, 2012
Enhancement of HB-EGF expression is directly or indirectly regulated by transcriptional factors, including activator protein-1 (AP-1), specificity protein (SP)1, SP3, nuclear factor kappa B (NF-κB), hypoxia inducible factor 1, alpha subunit (HIF-1α, myogenic differentiation 1 (MyoD), Wilms tumor 1 (WT-1) and snail homolog 1 (Snail), and also by microRNAs.
Extracellular signal-regulated kinase mitogen-activated protein kinase-dependent SOCS-3 gene induction requires c-Jun, signal transducer and activator of transcription 3, and specificity protein 3 transcription factors.
Yarwood et al., Glasgow, United Kingdom. In Mol Pharmacol, 2012
Extracellular signal-regulated kinase mitogen-activated protein kinase-dependent SOCS-3 gene induction requires c-Jun, signal transducer and activator of transcription 3, and specificity protein 3 transcription factors.
The p65 subunit of NF-κB inhibits COL1A1 gene transcription in human dermal and scleroderma fibroblasts through its recruitment on promoter by protein interaction with transcriptional activators (c-Krox, Sp1, and Sp3).
Galera et al., Caen, France. In J Biol Chem, 2012
The p65 subunit of NF-kappaB inhibits COL1A1 gene transcription in human dermal and scleroderma fibroblasts through its recruitment on promoter by protein interaction with transcriptional activators (c-Krox, Sp1, and Sp3).
Catalytic migratory oxidative coupling of nitrones through an outer-sphere C(sp3)-H activation process.
Kanai et al., Tokyo, Japan. In Chem Rec, 2011
Outer-sphere redox catalysis is key to efficient C-H activation, which has attracted increased interest in organic chemistry.
Pharmacologic doses of ascorbic acid repress specificity protein (Sp) transcription factors and Sp-regulated genes in colon cancer cells.
Safe et al., College Station, United States. In Nutr Cancer, 2010
Ascorbic acid decreased RKO and SW480 colon cancer cell proliferation and induced apoptosis and necrosis, accompanied by downregulation of Sp1, Sp3, and Sp4 proteins.
Malignant transformation of human skin fibroblasts by two alternative pathways.
Maher et al., East Lansing, United States. In Adv Exp Med Biol, 2010
by transfection of a v-MYC oncogene and spontaneous over-expression of transcription factors SP1/SP3.
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