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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Dec 2016.

SP100 nuclear antigen

This gene encodes a subnuclear organelle and major component of the PML (promyelocytic leukemia)-SP100 nuclear bodies. PML and SP100 are covalently modified by the SUMO-1 modifier, which is considered crucial to nuclear body interactions. The encoded protein binds heterochromatin proteins and is thought to play a role in tumorigenesis, immunity, and gene regulation. Alternatively spliced variants have been identified for this gene; one of which encodes a high-mobility group protein. [provided by RefSeq, Aug 2011] (from NCBI)
Top mentioned proteins: PBC, PML, gp210, HAD, CAN
Papers on Sp100
Tryptophan-containing lipopeptide antibiotics derived from polymyxin B with activity against Gram positive and Gram negative bacteria.
Cajal et al., Barcelona, Spain. In Biochim Biophys Acta, Feb 2016
Propelled by the antimicrobial potential of this compound class, we have designed three new lipopeptides derived from polymyxin B, sp-34, sp-96 and sp-100, with potent antimicrobial activity against both Gram positive and Gram negative bacteria.
The Significance of Autoantibody Changes Over Time in Primary Biliary Cirrhosis.
Hoofnagle et al., Bethesda, United States. In Am J Clin Pathol, Oct 2015
Of the autoantibodies tested, only sp100 changed significantly over time.
Reliability of the Effect of Artificial Anterior Chamber Pressure and Corneal Drying on Corneal Graft Thickness.
Kaye et al., Liverpool, United Kingdom. In Cornea, Aug 2015
Central corneal thickness was measured every 90 seconds for the first 15 minutes and again at 20 minutes using an ultrasound pachymeter (SP-100, Tomey).
Central corneal thickness determination in corneal edema using ultrasound pachymetry, a Scheimpflug camera, and anterior segment OCT.
Fuest et al., Aachen, Germany. In Graefes Arch Clin Exp Ophthalmol, Jul 2015
Two investigators acquired two measurements each, with the Pentacam (Oculus, Germany) and the AS-OCT (Heidelberg Engineering, Germany) in a randomized order, followed by USP (Tomey SP-100, Germany).
Selective recruitment of host factors by HSV-1 replication centers.
Zhou et al., Kunming, China. In Dongwuxue Yanjiu, Jun 2015
The centers also recruited components of the DNA damage response pathway, including 53BP1, BRCA1 and host antiviral protein SP100.
Physicochemical properties and sensory characteristics of sausage formulated with surimi powder.
Yang et al., George Town, Malaysia. In J Food Sci Technol, Mar 2015
The objectives of this study were to determine the physicochemical properties and sensory characteristics of fish sausage made with 100 % threadfin bream (Nemipterus japonicus) surimi powder (SP100), a mix of 50 % surimi powder and 50 % frozen surimi (SP50), and a control (100 % frozen surimi).
The tumor suppressor SHIP1 colocalizes in nucleolar cavities with p53 and components of PML nuclear bodies.
Jücker et al., Hamburg, Germany. In Nucleus, 2014
SP100, SUMO-1 and CK2).
Long-term action of propofol on cognitive function and hippocampal neuroapoptosis in neonatal rats.
Xu et al., Shanghai, China. In Int J Clin Exp Med, 2014
Four surgical groups were received an appendicectomy under propofol anesthesia and assigned as Con2, SP50, SP100, SP150.
Gene expression network analysis reveals new transcriptional regulators as novel factors in human ischemic cardiomyopathy.
Rivera et al., Valencia, Spain. In Bmc Med Genomics, 2014
We found that the expression of the transcriptional regulators SP100 (-1.5-fold, p < 0.05), CITED2 (-3.8-fold, p < 0.05), CEBPD (-4.9-fold, p < 0.05) and BCL3 (-3.3-fold, p < 0.05) were lower in ICM than in CNT.
SP140L, an Evolutionarily Recent Member of the SP100 Family, Is an Autoantigen in Primary Biliary Cirrhosis.
Peterson et al., Tartu, Estonia. In J Immunol Res, 2014
The SP100 family members comprise a set of closely related genes on chromosome 2q37.1.
Clinical significance of autoantibodies in primary biliary cirrhosis.
Nakamura, Ōmura, Japan. In Semin Liver Dis, 2014
Antimitochondrial, anti-gp210, anti-sp100, and anticentromere antibodies are specifically detected in primary biliary cirrhosis (PBC).
Overcoming a "probable" diagnosis in antimitochondrial antibody negative primary biliary cirrhosis: study of 100 sera and review of the literature.
Selmi et al., Italy. In Clin Rev Allergy Immunol, 2012
We included IIF AMA-negative PBC sera (n=100) and sera from patients with other chronic liver diseases (n=104) that had been independently tested for IIF AMA and ANA; sera were blindly tested with an ELISA PBC screening test including two ANA (gp210, sp100) and a triple (pMIT3) AMA recombinant antigens.
Herpesvirus saimiri antagonizes nuclear domain 10-instituted intrinsic immunity via an ORF3-mediated selective degradation of cellular protein Sp100.
Ensser et al., Erlangen, Germany. In J Virol, 2012
Herpesvirus saimiri tegument protein specifically degraded the cellular ND10 component Sp100.
Cdc20 mediates D-box-dependent degradation of Sp100.
Chen et al., Shanghai, China. In Biochem Biophys Res Commun, 2012
These findings expand our knowledge of both Sp100 and Cdc20 as well as their role in ubiquitination.
Human cytomegalovirus infection causes degradation of Sp100 proteins that suppress viral gene expression.
Ahn et al., Suwŏn, South Korea. In J Virol, 2011
These findings indicate that thehuman herpesvirus 5 IE1-dependent loss of human Sp100 proteins during virus infection may represent an important requirement for efficient viral growth.
Evidence for a dual antiviral role of the major nuclear domain 10 component Sp100 during the immediate-early and late phases of the human cytomegalovirus replication cycle.
Stamminger et al., Erlangen, Germany. In J Virol, 2011
Taken together, these data provide evidence that Sp100 is the first ND10-related factor identified that not only possesses the potential to restrict the initial stage of infection but also inhibits cytomegalovirus replication during the late phase.
Human cytomegalovirus immediate-early gene expression is restricted by the nuclear domain 10 component Sp100.
Stamminger et al., Erlangen, Germany. In J Gen Virol, 2011
Sp100 counteract human cytomegalovirus infection via the repression of viral immediate-early gene expression.
Autoimmune liver serology: current diagnostic and clinical challenges.
Vergani et al., London, United Kingdom. In World J Gastroenterol, 2008
PBC is specified by antimitochondrial antibodies (AMA) reacting with enzymes of the 2-oxo-acid dehydrogenase complexes (chiefly pyruvate dehydrogenase complex E2 subunit) and disease-specific ANA mainly reacting with nuclear pore gp210 and nuclear body sp100.
Primary biliary cirrhosis and autoantibodies.
Fritzler et al., In Nihon Rinsho Meneki Gakkai Kaishi, 2008
The use of enzyme linked immunosorbent assays that utilize recombinant gp210 (an autoantigen of the nuclear envelope) and/or sp100 (a protein target represented by multiple nuclear dots) should be particularly considered in anti-mitochondrial antibody negative PBC sera.
Are promyelocytic leukaemia protein nuclear bodies a scaffold for caspase-2 programmed cell death?
Rojas et al., Madrid, Spain. In Trends Biochem Sci, 2007
Here, we show that these nuclear structures have a protein known as SP100 that could contain a caspase recruitment domain (CARD).
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