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Surfactant protein C

SP-C, surfactant protein C
This gene encodes the pulmonary-associated surfactant protein C (SPC), an extremely hydrophobic surfactant protein essential for lung function and homeostasis after birth. Pulmonary surfactant is a surface-active lipoprotein complex composed of 90% lipids and 10% proteins which include plasma proteins and apolipoproteins SPA, SPB, SPC and SPD. The surfactant is secreted by the alveolar cells of the lung and maintains the stability of pulmonary tissue by reducing the surface tension of fluids that coat the lung. Multiple mutations in this gene have been identified, which cause pulmonary surfactant metabolism dysfunction type 2, also called pulmonary alveolar proteinosis due to surfactant protein C deficiency, and are associated with interstitial lung disease in older infants, children, and adults. Alternatively spliced transcript variants encoding different protein isoforms have been identified.[provided by RefSeq, Feb 2010] (from NCBI)
Top mentioned proteins: CAN, HAD, V1a, ACID, AGE
Papers using SP-C antibodies
Genome-wide siRNA-based functional genomics of pigmentation identifies novel genes and pathways that impact melanogenesis in human cells
Kim Dong-Seok et al., In Journal of Biomedical Science, 2007
... SPC was purchased from Avanti Polar Lipids (Alabaster, AL, USA); LY294002 and rapamycin were from Cell Signaling Technology (Beverly, MA, USA) ...
Studies on the Epstein-Barr virus genome [Ph.D. thesis].
Hensel Michael, In PLoS ONE, 1983
... Chloramphenicol (Cm; 10 µg/ml; Roth, Karlsruhe, Germany), erythromycin (Em; 10 µg/ml; Merck, Darmstadt, Germany), spectinomycin (Spc; 150 µg/ml; Sigma Aldrich, München, Germany), tetracycline (Tc; ...
Papers on SP-C
The effects of increasing dietary levels of amino acid-supplemented soy protein concentrate and constant dietary supplementation of phosphorus on growth, composition and immune responses of juvenile Atlantic salmon (Salmo salar L.).
Thompson et al., Stirling, United Kingdom. In Fish Physiol Biochem, Feb 2016
UNASSIGNED: Diets with 50 (SPC50), 65 (SPC65) and 80 % (SPC80) substitution of prime fish meal (FM) with soy protein concentrate (SPC) were evaluated against a commercial type control feed with 35 % FM replacement with SPC.
Phospholipid Composition in Synthetic Surfactants Is Important for Tidal Volumes and Alveolar Stability in Surfactant-Treated Preterm Newborn Rabbits.
Curstedt et al., Stockholm, Sweden. In Neonatology, Feb 2016
OBJECTIVES: To investigate the effects of phospholipid mixtures combined with SP-B and SP-C analogues on lung functions in an animal model of respiratory distress syndrome.
Hyperoxia causes diffuse alveolar damage through mechanisms involving upregulation of c-Myc/Bax and enhanced production of reactive oxygen species.
Suzuki et al., Fukui, Japan. In Respir Investig, Jan 2016
RESULTS: Hyperoxia induced a decrease in SP-C/A expression in mouse lungs, and SP-C downregulation was also confirmed in A549 cells.
Systematic review and meta-analysis on management of acute urinary retention.
Woo et al., Sydney, Australia. In Prostate Cancer Prostatic Dis, Dec 2015
Suprapubic catheter (SPC) is an alternative to urethral catheterisation (indwelling catheter (IDC)) and may provide several advantages.
Effects of the New Generation Synthetic Reconstituted Surfactant CHF5633 on Pro- and Anti-Inflammatory Cytokine Expression in Native and LPS-Stimulated Adult CD14+ Monocytes.
Speer et al., Würzburg, Germany. In Plos One, Dec 2015
CHF5633, a new generation reconstituted synthetic surfactant containing SP-B and SP-C analogs and two synthetic phospholipids has demonstrated biophysical effectiveness in vitro and in vivo.
Kostikas et al., Athens, Greece. In Curr Top Med Chem, Oct 2015
The protein part of surfactant constitutes two hydrophilic proteins (SP-A and SP-D) that regulate surfactant metabolism and have immunologic functions, and two hydrophobic proteins (SP-B and SP-C), which play a direct role in the organization of the surfactant structure in the interphase and in the stabilization of the lipid layers during the respiratory cycle.
Lost after translation: insights from pulmonary surfactant for understanding the role of alveolar epithelial dysfunction and cellular quality control in fibrotic lung disease.
Beers et al., Ōita, Japan. In Am J Physiol Lung Cell Mol Physiol, Oct 2015
Drawing on data generated from a variety of model systems expressing disease-related surfactant component mutations [surfactant proteins A and C (SP-A and SP-C); the lipid transporter ABCA3], this review will examine the concept of epithelial dysfunction in fibrotic lung disease, provide an update on AT2 cell and surfactant biology, summarize cellular responses to mutant surfactant components [including endoplasmic reticulum (ER) stress, mitochondrial dysfunction, and intrinsic apoptosis], and examine quality control pathways (unfolded protein response, the ubiquitin-proteasome system, macroautophagy) that can be utilized to restore AT2 homeostasis.
The Role of Surfactant in Lung Disease and Host Defense against Pulmonary Infections.
Mallampalli et al., Chi-lung, Taiwan. In Ann Am Thorac Soc, May 2015
Surfactant is enriched with a relatively unique phospholipid, termed dipalmitoylphosphatidylcholine, and four surfactant-associated proteins, SP-A, SP-B, SP-C, and SP-D.
Expression of PHF20 protein contributes to good prognosis of NSCLC and is associated with Bax expression.
Qiu et al., Shenyang, China. In Int J Clin Exp Pathol, 2014
METHODS: We investigated the expression of PHF20 in 142 cases of NSCLC tissue and 30 cases of normal lung tissue by immunohistochemical staining and downregulated PHF20 expression in SPC cell.
Sphingosylphosphorylcholine in cancer progress.
Zhao et al., Jinan, China. In Int J Clin Exp Med, 2014
Sphingosylphosphorylcholine (SPC) is a naturally occurring bioactive sphingolipid in blood plasma, metabolizing from the hydrolysis of the membrane sphingolipid.
Urocortin 3 elevates cytosolic calcium in nucleus ambiguus neurons.
Brailoiu et al., Philadelphia, United States. In J Neurochem, 2012
A novel divalent calcium ion-mobilizing effect of urocortin 3 in vagal pre-ganglionic neurons of the nucleus ambiguus provides a cellular mechanism for this peptide's role in parasympathetic cardiac regulation.
Alteration of antral and proximal colonic motility induced by chronic psychological stress involves central urocortin 3 and vasopressin in rats.
Fujimiya et al., Sapporo, Japan. In Am J Physiol Gastrointest Liver Physiol, 2012
Chronic psychological stress disrupted fasted motility in the antrum and colon via central urocortin 3/arginine vasopression pathways.
Hypothalamic expression of urocortin 3 and the type 2 corticotropin-releasing factor receptor is regulated according to feeding state in lean but not obese Zucker rats.
Timofeeva et al., Québec, Canada. In Neuropharmacology, 2012
The results showed that in the ad libitum-fed state, both phenotypes had comparable levels of expression of rostral perifornical hypothalamus Ucn3.Food deprivation decreased hypothalamic expression of Ucn3 in lean but not obese rats.
Effects of urocortin 2 and urocortin 3 on IL-10 and TNF-α expression and secretion from human trophoblast explants.
Petraglia et al., Siena, Italy. In Placenta, 2011
study showed that Ucn2 and Ucn3 differentially regulate the LPS-induced TNF-alpha and IL-10 expression and secretion in trophoblast explants acting through CRH-R2. Ucn3 has an anti-inflammatory effect.
The surfactant protein C mutation A116D alters cellular processing, stress tolerance, surfactant lipid composition, and immune cell activation.
Griese et al., München, Germany. In Bmc Pulm Med, 2011
The A116D mutation leads to impaired processing of proSP-C in alveolar epithelial cells, alters cell viability and lipid composition, and also activates cells of the immune system.
Plzf regulates germline progenitor self-renewal by opposing mTORC1.
Pandolfi et al., Boston, United States. In Cell, 2010
We find that SPCs lacking Plzf, a transcription factor essential for SPC maintenance, have enhanced mTORC1 activity.
The role of Scgb1a1+ Clara cells in the long-term maintenance and repair of lung airway, but not alveolar, epithelium.
Hogan et al., Durham, United States. In Cell Stem Cell, 2009
In the postnatal mouse lung, it has been proposed that bronchioalveolar stem cells (BASCs) which coexpress Scgb1a1 (Secretoglobin1a1) and SftpC (Surfactant Protein C), contribute descendants to both bronchioles and alveoli.
Differential mobilization of subsets of progenitor cells from the bone marrow.
Rankin et al., London, United Kingdom. In Cell Stem Cell, 2009
Furthermore, SPC mobilization was detected when the CXCR4 antagonist was administered to mice pretreated with VEGF, but not G-CSF.
Biomimicry of surfactant protein C.
Barron et al., Evanston, United States. In Acc Chem Res, 2008
This is largely because the previous synthetic formulations lacked analogues of the hydrophobic proteins of the lung surfactant system, SP-B and SP-C, which are critical functional constituents.
Generation of functional multipotent adult stem cells from GPR125+ germline progenitors.
Rafii et al., New York City, United States. In Nature, 2007
Primary GPR125-LacZ SPC lines retained GPR125 expression, underwent clonal expansion, maintained the phenotype of germline stem cells, and reconstituted spermatogenesis in busulphan-treated mice.
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