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Surfactant protein A1

SP-A, Pulmonary Surfactant-Associated Protein A, surfactant protein A, PspA
This gene encodes a lung surfactant protein that is a member of a subfamily of C-type lectins called collectins. The encoded protein binds specific carbohydrate moieties found on lipids and on the surface of microorganisms. This protein plays an essential role in surfactant homeostasis and in the defense against respiratory pathogens. Mutations in this gene are associated with idiopathic pulmonary fibrosis. Alternate splicing results in multiple transcript variants. [provided by RefSeq, May 2010] (from NCBI)
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Top mentioned proteins: SP-D, CAN, HAD, V1a, SP-C
Papers on SP-A
Protective effect of Ac-SDKP on alveolar epithelial cells through inhibition of EMT via TGF-β1/ROCK1 pathway in silicosis in rat.
Yang et al., Tangshan, China. In Toxicol Appl Pharmacol, Feb 2016
Confocal laser scanning microscopy was used to examine colocalization of surfactant protein A (SP-A), fibroblast specific protein-1 (FSP-1) and α-smooth muscle actin (α-SMA) in vivo.
Surfactant Protein A Enhances Constitutive Immune Functions of Clathrin Heavy Chain and Clathrin Adaptor Protein AP2.
Stamme et al., Germany. In Am J Respir Cell Mol Biol, Feb 2016
Here we dissect endocytic from alternative functions of CHC, the α-subunit of AP2, and dynamin in basal and SP-A-modified lipopolysaccharide (LPS) signaling of macrophages.
Proteomic analysis of the TerC interactome: Novel links to tellurite resistance and pathogenicity.
Aradska et al., Vienna, Austria. In J Proteomics, Feb 2016
An interactome has been constructed and robust physical interaction of integral membrane protein TerC with TerB, DctA, PspA, HslU, and RplK has been shown.
Enrichment of immunoregulatory proteins in the biomolecular corona of nanoparticles within human respiratory tract lining fluid.
Mudway et al., Dublin, Ireland. In Nanomedicine, Feb 2016
The evolved PVAc corona was significantly enriched compared to that observed on SiO2 nanoparticles (698 vs. 429 proteins identified); however both coronas contained a substantial contribution from innate immunity proteins, including surfactant protein A, napsin A and complement (C1q and C3) proteins.
Binding sites for interaction of peroxiredoxin 6 with surfactant protein A.
Fisher et al., Philadelphia, United States. In Biochim Biophys Acta, Jan 2016
We have shown previously that the PLA2 activity of Prdx6 is inhibited by the lung surfactant-associated protein called surfactant protein A (SP-A) through direct protein-protein interaction.
Murine models of Aspergillosis: Role of collectins in host defense.
Sarma et al., In Indian J Exp Biol, Nov 2015
Collectins, namely surfactant protein A (SP-A), surfactant protein D (SP-D) and mannan binding lectin (MBL), are pattern recognition molecules regulating both innate and adaptive immune response against pathogens.
Kostikas et al., Athens, Greece. In Curr Top Med Chem, Oct 2015
The protein part of surfactant constitutes two hydrophilic proteins (SP-A and SP-D) that regulate surfactant metabolism and have immunologic functions, and two hydrophobic proteins (SP-B and SP-C), which play a direct role in the organization of the surfactant structure in the interphase and in the stabilization of the lipid layers during the respiratory cycle.
Lost after translation: insights from pulmonary surfactant for understanding the role of alveolar epithelial dysfunction and cellular quality control in fibrotic lung disease.
Beers et al., Ōita, Japan. In Am J Physiol Lung Cell Mol Physiol, Oct 2015
Drawing on data generated from a variety of model systems expressing disease-related surfactant component mutations [surfactant proteins A and C (SP-A and SP-C); the lipid transporter ABCA3], this review will examine the concept of epithelial dysfunction in fibrotic lung disease, provide an update on AT2 cell and surfactant biology, summarize cellular responses to mutant surfactant components [including endoplasmic reticulum (ER) stress, mitochondrial dysfunction, and intrinsic apoptosis], and examine quality control pathways (unfolded protein response, the ubiquitin-proteasome system, macroautophagy) that can be utilized to restore AT2 homeostasis.
Is the cellular and molecular machinery docile in the stationary phase of Escherichia coli?
Buck et al., London, United Kingdom. In Biochem Soc Trans, Apr 2015
The Psp system consists of a transcriptional activator PspF, negative regulator PspA, signal sensors PspBC, with PspA and PspG acting as effectors.
[Significance of surfactant proteins in the diagnosis of therapeutic diseases].
Voevoda et al., In Ter Arkh, 2014
The hydrophilic proteins SP-A and SP-D are responsible for the regulation of the latter.
Novel role for surfactant protein A in gastrointestinal graft-versus-host disease.
Palmer et al., Durham, United States. In J Immunol, 2012
The presence of increased T helper type (Th)17 cells in the gastrointestinal tract in association with a subsequent decrease in regulatory T cells suggests a potential role for SP-A in influencing these T cell subsets in extrapulmonary tissues.
Surfactant protein A modulates induction of regulatory T cells via TGF-β.
Wright et al., Durham, United States. In J Immunol, 2012
SP-A affects T cell immune function by the induction of Tregs during activation.
Pulmonary surfactant protein A protects lung epithelium from cytotoxicity of human β-defensin 3.
Kuroki et al., Sapporo, Japan. In J Biol Chem, 2012
SP-A protects lung epithelium from tissue injury caused by BD3
Surfactant protein A integrates activation signal strength to differentially modulate T cell proliferation.
Wright et al., Durham, United States. In J Immunol, 2012
SP-A appears to integrate signal thresholds to control T cell proliferation
Surfactant protein-A suppresses eosinophil-mediated killing of Mycoplasma pneumoniae in allergic lungs.
Wright et al., Durham, United States. In Plos One, 2011
Surfactant protein-A suppresses eosinophil-mediated killing of Mycoplasma pneumoniae in allergic lungs
Immunoregulatory functions of surfactant proteins.
Wright, Durham, United States. In Nat Rev Immunol, 2005
In this article, I review the structure and functions of the surfactant proteins SP-A and SP-D in regulating host immune defence and in modulating inflammatory responses.
By binding SIRPalpha or calreticulin/CD91, lung collectins act as dual function surveillance molecules to suppress or enhance inflammation.
Henson et al., Denver, United States. In Cell, 2003
Data show that surfactant proteins-A and -D bind SIRPalpha through globular heads to block proinflammatory mediator production, while binding to their collagenous tails stimulates proinflammatory mediator production through binding to calreticulin.
Collections and ficolins: humoral lectins of the innate immune defense.
Jensenius et al., Denmark. In Annu Rev Immunol, 2002
The human collectins, mannan-binding lectin (MBL) and surfactant protein A and D (SP-A and SP-D), are oligomeric proteins composed of carbohydrate-recognition domains (CRDs) attached to collagenous regions and are thus structurally similar to the ficolins, L-ficolin, M-ficolin, and H-ficolin.
Pathogenesis of high-altitude pulmonary edema: inflammation is not an etiologic factor.
Bärtsch et al., Seattle, United States. In Jama, 2002
Subjects who developed HAPE had BAL fluid with high concentrations of plasma-derived proteins and erythrocytes, but there was no increase in plasma concentrations of surfactant protein A and Clara cell protein.
Damage to surfactant-specific protein in acute respiratory distress syndrome.
Haslam et al., London, United Kingdom. In Lancet, 1999
We then used western blotting with monoclonal antibody E8 to detect the major surfactant-specific protein A (SP-A).
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