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Acrosomal vesicle protein 1
SP-10, ACRV1, acrosomal protein SP-10, MSA-63
This gene encodes a testis-specific, differentiation antigen, acrosomal vesicle protein 1, that arises within the acrosomal vesicle during spermatogenesis, and is associated with the acrosomal membranes and matrix of mature sperm. The acrosomal vesicle protein 1 may be involved in sperm-zona binding or penetration. Alternatively spliced transcript variants have been described. [provided by RefSeq, Nov 2010] (from
NCBI)
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Papers on
SP-10
Design of a box trainer for objective assessment of technical skills in single-port surgery.
New
Delft, Netherlands. In J Surg Educ, Jul 2015
SD = 2.1), tissue manipulation force (SP-10.4N,
The acrosomal protein SP-10 (Acrv1) is an ideal marker for staging of the cycle of seminiferous epithelium in the mouse.
Charlottesville, United States. In Mol Reprod Dev, 2014
Here we demonstrate that a polyclonal antibody raised against the mouse acrosomal protein SP-10 is extremely useful for stage identification.
Validation of the pulse decomposition analysis algorithm using central arterial blood pressure.
Charlottesville, United States. In Biomed Eng Online, 2013
Bland-Altman comparisons between blood pressures obtained through the conversion of PDA parameters to blood pressures of non-invasively obtained pulse signatures with catheter-obtained blood pressures fell within the trend guidelines of the Association for the Advancement of Medical Instrumentation SP-10 standard (standard deviation: 8 mmHg(systole: 5.87 mmHg, diastole: 5.69 mmHg)).
Basigin null mutant male mice are sterile and exhibit impaired interactions between germ cells and Sertoli cells.
Urbana, United States. In Dev Biol, 2013
However, only punctate expression of the round spermatid marker SP-10 in the acrosomal granule of germ cells of Bsg KO mice was detected indicating that spermatogenesis in Bsg KO mice was arrested at the early round spermatid stages.
Acupuncture and in vitro fertilization: a retrospective chart review.
Portland, United States. In J Altern Complement Med, 2013
After transfer the points were LI-4, SP-10, ST-36, SP-6, KI-3; Uterus and Endocrine on the left ear; and Shenmen and Brain on the right ear.
Evaluation of efficacy and safety of recombinant sperm-specific contraceptive vaccine in albino mice.
Jaipur, India. In Am J Reprod Immunol, 2013
PROBLEM: This study was undertaken to evaluate the efficacy and safety of recombinant SP-10 protein for male contraception.
Involvement of the prostate and testis expression (PATE)-like proteins in sperm-oocyte interaction.
Tel Aviv-Yafo, Israel. In Hum Reprod, 2012
They are localized in the sperm head and are homologous to SP-10, the acrosomal vesicle protein also named ACRV1.
Differentiation of murine male germ cells to spermatozoa in a soft agar culture system.
Beersheba, Israel. In Asian J Androl, 2012
Immunofluorescence and real-time PCR were used to analyse specific markers expressed in undifferentiated and differentiated spermatogonia (Vasa, Dazl, OCT-4, C-Kit, GFR-α-1, CD9 and α-6-integrin), meiotic cells (LDH, Crem-1 and Boule) and post-meiotic cells (Protamine-1, Acrosin and SP-10).
Developmental expression of ACRV1 in humans and mice.
GeneRIF
Shenzhen, China. In Andrologia, 2012
Using RT-PCR analysis of mouse ACRV1, we determined that ACRV1 was expressed specifically in the testis, and its expression began at days 35.
TDP-43 is a transcriptional repressor: the testis-specific mouse acrv1 gene is a TDP-43 target in vivo.
GeneRIF
Charlottesville, United States. In J Biol Chem, 2011
TDP-43 is a transcriptional repressor and that it regulates spatiotemporal expression of the acrv1 gene during spermatogenesis.
Members of the murine Pate family are predominantly expressed in the epididymis in a segment-specific fashion and regulated by androgens and other testicular factors.
Turku, Finland. In Reprod Biol Endocrinol, 2010
RESULTS: A revised family tree of Pate genes is presented, including a previously uncharacterized Pate gene named Pate-X, and the data revealed that Acrv1 and Sslp1 should also be considered as members of the Pate family.
NF45 and NF90 in murine seminiferous epithelium: potential role in SP-10 gene transcription.
GeneRIF
Charlottesville, United States. In J Androl, 2008
we propose that NF45 and NF90 have the potential to activate SP-10 gene transcription, and that a chromatin modification event must occur first in order to provide access to these transcription factors.
A novel CpG-free vertebrate insulator silences the testis-specific SP-10 gene in somatic tissues: role for TDP-43 in insulator function.
GeneRIF
Charlottesville, United States. In J Biol Chem, 2008
A novel CpG-free vertebrate insulator silences the testis-specific SP-10 gene in somatic tissues: role for TDP-43 in insulator function.
Role of an insulator in testis-specific gene transcription.
Review
Charlottesville, United States. In Ann N Y Acad Sci, 2007
Studies from our laboratory using the round spermatid-specific SP-10 gene as an experimental model have provided some insights into the mechanisms involved.
Immunological response in the primate oviduct to a defined recombinant sperm immunogen.
Review
Charlottesville, United States. In J Reprod Immunol, 1997
Subsequent assays of relative and absolute concentrations of antibodies in oviductal fluid and serum demonstrated the presence of IgA and IgG specific for the recombinant sperm immunogen SP-10 in fluid collected from the periovulatory oviduct of primates after intramuscular inoculations.
Sperm antigens and their use in the development of an immunocontraceptive.
Review
Charlottesville, United States. In Am J Reprod Immunol, 1997
Studies that utilized monoclonal antibodies and polyclonal antisera generated against sperm preparations have identified such promising candidates as PH-20, fertilin, SP-17, and SP-10.
Sperm antigens and immunocontraception.
Review
Edinburgh, United Kingdom. In Reprod Fertil Dev, 1994
SP-10, PH-20 and PH-30).
Vaccines for control of fertility.
Review
New Delhi, India. In Indian J Exp Biol, 1992
SP-10, which is a testis-specific human sperm protein, is also a promising candidate.
