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SRY-box containing gene 6

Sox6, SoxD
This gene encodes a member of the D subfamily of sex determining region y-related transcription factors that are characterized by a conserved DNA-binding domain termed the high mobility group box and by their ability to bind the minor groove of DNA. The encoded protein is a transcriptional activator that is required for normal development of the central nervous system, chondrogenesis and maintenance of cardiac and skeletal muscle cells. The encoded protein interacts with other family members to cooperatively activate gene expression. Alternative splicing results in multiple transcript variants.[provided by RefSeq, Mar 2009] (from NCBI)
Top mentioned proteins: Sox, Sox5, CAN, SRY, miR
Papers on Sox6
SOX6 and PDCD4 enhance cardiomyocyte apoptosis through LPS-induced miR-499 inhibition.
Zhou et al., Beijing, China. In Apoptosis, Feb 2016
We found that LPS stimulation inhibited microRNA (miR)-499 expression and thereby upregulated the expression of SOX6 and PDCD4 in neonatal rat cardiomyocytes.
Pomalidomide reverses γ-globin silencing through the transcriptional reprogramming of adult hematopoietic progenitors.
Blanc et al., United States. In Blood, Jan 2016
Further, the transcription networks involved in γ-globin repression were selectively and differentially affected by pomalidomide including BCL11A, SOX6, IKZF1, KLF1, and LSD1.
Role of microRNA-21 in the formation of insulin-producing cells from pancreatic progenitor cells.
Guan et al., Beijing, China. In Biochim Biophys Acta, Jan 2016
We found that miR-21 acts as a bidirectional switch in the formation of IPCs by regulating the expression of target and downstream genes (SOX6, RPBJ and HES1).
High expression of microRNA-208 is associated with cardiac hypertrophy via the negative regulation of the sex-determining region Y-box 6 protein.
Li et al., Zhumadian, China. In Exp Ther Med, Sep 2015
UNASSIGNED: The aim of this study was to investigate the expression levels of microRNA-208 (miR-208) and sex-determining region Y-box 6 (SOX6) in patients with progressive cardiac hypertrophy.
Impact of epigenetic mechanisms on therapeutic approaches of hemoglobinopathies.
Napoli et al., Napoli, Italy. In Blood Cells Mol Dis, Aug 2015
Particularly interesting are the recent data on miRNAs showing the interaction of these molecules with different transcription factors such as MYB, KLF, BCL11A and SOX6.
From CNS stem cells to neurons and glia: Sox for everyone.
Wegner et al., Erlangen, Germany. In Cell Tissue Res, 2015
Sox transcription factors are central to this regulatory network, especially members of the SoxB, SoxC, SoxD, SoxE and SoxF groups.
Gene expression analysis at the onset of sex differentiation in turbot (Scophthalmus maximus).
Viñas et al., Santiago de Compostela, Spain. In Bmc Genomics, 2014
We also detected changes in the expression levels of several genes (ctnnb1, cyp11a, dmrt2 or sox6) depending on culture temperature.
MicroRNA-766 targeting regulation of SOX6 expression promoted cell proliferation of human colorectal cancer.
Zhang et al., Changchun, China. In Onco Targets Ther, 2014
Bioinformatic analysis predicted SOX6, a potential target of miR-766, acting as a tumor suppressor.
Hsa-mir-1269 genetic variant contributes to hepatocellular carcinoma susceptibility through affecting SOX6.
Yang et al., Nanjing, China. In Am J Transl Res, 2014
SOX6 was predicted as a potential target gene of miR-as.
MiR-202 promotes endometriosis by regulating SOX6 expression.
Wang et al., Kaifeng, China. In Int J Clin Exp Med, 2014
The protein expressions of SOX6 (sex determining region Y-box 6) and its downstream proteins (p21, cyclin D1 and pRb (retinoblastoma protein)) were detected by immunochemistry and western blot.
Cartilage development requires the function of Estrogen-related receptor alpha that directly regulates sox9 expression in zebrafish.
Park et al., Iksan, South Korea. In Sci Rep, 2014
Loss of function analysis shows that knockdown of esrra impairs expression of genes including sox9, col2a1, sox5, sox6, runx2 and col10a1 thus induces abnormally formed cartilage in pharyngeal arches.
Fetal globin gene repressors as drug targets for molecular therapies to treat the β-globinopathies.
Engel et al., Sendai, Japan. In Mol Cell Biol, 2014
Multiple reports have now identified several transcription factors that are involved in fetal globin gene repression in definitive (adult)-stage erythroid cells (the TR2/TR4 heterodimer, MYB, KLFs, BCL11A, and SOX6).
Clinical review: Genome-wide association studies of skeletal phenotypes: what we have learned and where we are headed.
Kiel et al., Boston, United States. In J Clin Endocrinol Metab, 2012
Among 59 novel BMD GWAS loci that have not been reported by previous candidate gene association studies, some have been shown to be involved in key biological pathways involving the skeleton, particularly Wnt signaling (AXIN1, LRP5, CTNNB1, DKK1, FOXC2, HOXC6, LRP4, MEF2C, PTHLH, RSPO3, SFRP4, TGFBR3, WLS, WNT3, WNT4, WNT5B, WNT16), bone development: ossification (CLCN7, CSF1, MEF2C, MEPE, PKDCC, PTHLH, RUNX2, SOX6, SOX9, SPP1, SP7), mesenchymal-stem-cell differentiation (FAM3C, MEF2C, RUNX2, SOX4, SOX9, SP7), osteoclast differentiation (JAG1, RUNX2), and TGF-signaling (FOXL1, SPTBN1, TGFBR3).
L-Sox5 and Sox6 proteins enhance chondrogenic miR-140 microRNA expression by strengthening dimeric Sox9 activity.
Asahara et al., Tokyo, Japan. In J Biol Chem, 2012
L-Sox5 and Sox6 proteins enhance chondrogenic miR-140 microRNA expression by strengthening dimeric Sox9 activity
Prdm1a and miR-499 act sequentially to restrict Sox6 activity to the fast-twitch muscle lineage in the zebrafish embryo.
Ingham et al., Singapore, Singapore. In Development, 2011
identify sox6 cis-regulatory sequences that drive fast-twitch-specific expression in a Prdm1a-dependent manner
Concerted regulation of myofiber-specific gene expression and muscle performance by the transcriptional repressor Sox6.
Olson et al., Dallas, United States. In Proc Natl Acad Sci U S A, 2011
These results identify Sox6 as a robust regulator of muscle contractile phenotype and metabolism, and elucidate a mechanism by which functionally related muscle fiber-type specific gene isoforms are collectively controlled.
SOX trio decrease in the articular cartilage with the advancement of osteoarthritis.
Im et al., South Korea. In Connect Tissue Res, 2010
SOX trio gene and protein decreased with advancement of osteoarthritis in human articular cartilage.
Genome-wide mapping of Sox6 binding sites in skeletal muscle reveals both direct and indirect regulation of muscle terminal differentiation by Sox6.
Hagiwara et al., Davis, United States. In Bmc Dev Biol, 2010
during development, Sox6 functions as a transcriptional suppressor of fiber type-specific and developmental isoform genes to promote functional specification of muscle which is critical for optimum muscle performance and health.
Targeted therapeutic strategies for fetal hemoglobin induction.
Sankaran, Boston, United States. In Hematology Am Soc Hematol Educ Program, 2010
This article reviews these developments and discusses how molecules including BCL11A, KLF1, MYB, SOX6, miRNAs 15a and 16-1, and histone deacetylase 1 and 2 (HDAC1/2) could be important targets for HbF induction in humans.
Twenty bone-mineral-density loci identified by large-scale meta-analysis of genome-wide association studies.
Genetic Factors for Osteoporosis (GEFOS) Consortium et al., Rotterdam, Netherlands. In Nat Genet, 2009
(LRP4, ARHGAP1, F2), 11p14.1 (DCDC5), 11p15 (SOX6), 16q24 (FOXL1), 17q21 (HDAC5) and 17q12 (CRHR1).
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