How Does p73 Cause Neuronal Defects?
Leicester, United Kingdom. In Mol Neurobiol, Sep 2015
In particular, TAp73 is involved in the maintenance of neural stem/progenitor cell self-renewal and differentiation throughout the regulation of SOX-2, Hey-2, TRIM32 and Notch.
Pluripotency Genes and Their Functions in the Normal and Aberrant Breast and Brain.
Perth, Australia. In Int J Mol Sci, 2014
They share certain characteristics with ESCs, such as an inherent capacity to self-renew and differentiate into cells of the three germ layers, properties that are regulated by master pluripotency transcription factors (TFs) OCT4 (octamer-binding transcription factor 4), SOX2 (sex determining region Y-box 2), and homeobox protein NANOG.
Targeting Aggressive Cancer Stem Cells in Glioblastoma.
Australia. In Front Oncol, 2014
Targeting pluripotency transcription factors, SOX2, OCT4, and Nanog homeobox, demonstrates promising therapeutic potential that if applied in isolation or together with current treatments may improve overall survival, reduce tumor relapse, and achieve a cure for these patients.