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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Dec 2016.


This intronless gene encodes a member of the SRY-related HMG-box (SOX) family of transcription factors involved in the regulation of embryonic development and in the determination of cell fate. The product of this gene is required for stem-cell maintenance in the central nervous system, and also regulates gene expression in the stomach. Mutations in this gene have been associated with optic nerve hypoplasia and with syndromic microphthalmia, a severe form of structural eye malformation. This gene lies within an intron of another gene called SOX2 overlapping transcript (SOX2OT). [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: Nanog, CAN, KLF4, c-Myc, HAD
Papers using Sox2 antibodies
The karyopherin Kap142p/Msn5p mediates nuclear import and nuclear export of different cargo proteins
Rottier Robbert J. et al., In The Journal of Cell Biology, 2000
... Other antibodies were against Flag (M2; Sigma-Aldrich), Sox2 (Millipore), Oct3/4 (Santa Cruz Biotechnology, Inc.), nestin, and RC2 ...
Papers on Sox2
P53 and SOX2 Protein Expression Predicts Esophageal Adenocarcinoma in Response to Neoadjuvant Chemoradiotherapy.
Looijenga et al., Rotterdam, Netherlands. In Ann Surg, Feb 2016
OBJECTIVE: The aim of the study was to investigate the association between p53, SOX2, and CD44 protein expression and tumor response, and to validate potential predictive biomarker(s) in an independent cohort.
Conversion of Prostate Adenocarcinoma to Small Cell Carcinoma-Like by Reprogramming.
Liu et al., Goiânia, Brazil. In J Cell Physiol, Feb 2016
Expression of four stem cell transcription factor (TF) genes, LIN28A, NANOG, POU5F1, SOX2, were analyzed in the LuCaP lines.
Overexpression of SDF-1 activates the NF-κB pathway to induce epithelial to mesenchymal transition and cancer stem cell-like phenotypes of breast cancer cells.
Li et al., Mudanjiang, China. In Int J Oncol, Feb 2016
accompanied by the apparently elevated ALDH activity and the upregulation of the stem cell markers OCT-4, Nanog, and SOX2 compared with parental (P<0.01).
WNT pathway inhibitor pyrvinium pamoate inhibits the self-renewal and metastasis of breast cancer stem cells.
Zhang et al., Shanghai, China. In Int J Oncol, Feb 2016
Moreover, in-depth analysis revealed that PP caused inhibition of WNT pathway activity and stemness regulator expression including NANOG, SOX2 and OCT4, which were inherently upregulated in the BCSCs as compared with the bulk of cells within the tumor.
NANOG alone induces germ cells in primed epiblast in vitro by activation of enhancers.
Azim Surani et al., Kōbe, Japan. In Nature, Feb 2016
Furthermore, while SOX2 and NANOG promote the pluripotent state in ES cells, they show contrasting roles in EpiLCs, as Sox2 specifically represses PGCLC induction by Nanog.
Stepwise Clearance of Repressive Roadblocks Drives Cardiac Induction in Human ESCs.
Greber et al., Münster, Germany. In Cell Stem Cell, Jan 2016
First, BMP and WNT signals pattern mesendoderm through cooperative repression of SOX2, a potent mesoderm antagonist.
Regulatory System for Stem/Progenitor Cell Niches in the Adult Rodent Pituitary.
Kato et al., Japan. In Int J Mol Sci, Dec 2015
Although the turnover rate of pituitary endocrine cells is as low as about 1.6% per day, recent studies have demonstrated that Sex-determining region Y-box 2 (SOX2)⁺-cells exist as pituitary stem/progenitor cells in the adult anterior lobe and contribute to cell regeneration.
Mutations in TP53 increase the risk of SOX2 copy number alterations and silencing of TP53 reduces SOX2 expression in non-small cell lung cancer.
Zienolddiny et al., Oslo, Norway. In Bmc Cancer, Dec 2015
BACKGROUND: Amplifications of the transcription factor, SRY (sex determining region Y)-box 2 (SOX2), are common in non-small cell lung cancer (NSCLC).
Ground State Conditions Induce Rapid Reorganization of Core Pluripotency Factor Binding before Global Epigenetic Reprogramming.
Meissner et al., Cambridge, United States. In Cell Stem Cell, Nov 2015
Here we show that 2i conditions rapidly alter the global binding landscape of OCT4, SOX2, and NANOG.
SMARCA4 inactivation defines a group of undifferentiated thoracic malignancies transcriptionally related to BAF-deficient sarcomas.
Tirode et al., Lyon, France. In Nat Genet, Oct 2015
Transcriptome analyses, further validated by immunohistochemistry, highlighted strong expression of SOX2, a marker that supports the differential diagnosis of these tumors from SMARCA4-deficient lung carcinomas.
How Does p73 Cause Neuronal Defects?
Agostini et al., Leicester, United Kingdom. In Mol Neurobiol, Sep 2015
In particular, TAp73 is involved in the maintenance of neural stem/progenitor cell self-renewal and differentiation throughout the regulation of SOX-2, Hey-2, TRIM32 and Notch.
Engineering Human Stem Cell Lines with Inducible Gene Knockout using CRISPR/Cas9.
Zhang et al., Madison, United States. In Cell Stem Cell, Sep 2015
This two-step strategy was used to establish human embryonic stem cell (hESC) and induced pluripotent stem cell (iPSC) lines with iKO of SOX2, PAX6, OTX2, and AGO2, genes that exhibit diverse structural layout and temporal expression patterns.
Pluripotency Genes and Their Functions in the Normal and Aberrant Breast and Brain.
Kakulas et al., Perth, Australia. In Int J Mol Sci, 2014
They share certain characteristics with ESCs, such as an inherent capacity to self-renew and differentiate into cells of the three germ layers, properties that are regulated by master pluripotency transcription factors (TFs) OCT4 (octamer-binding transcription factor 4), SOX2 (sex determining region Y-box 2), and homeobox protein NANOG.
Targeting Aggressive Cancer Stem Cells in Glioblastoma.
Kakulas et al., Australia. In Front Oncol, 2014
Targeting pluripotency transcription factors, SOX2, OCT4, and Nanog homeobox, demonstrates promising therapeutic potential that if applied in isolation or together with current treatments may improve overall survival, reduce tumor relapse, and achieve a cure for these patients.
Long non-coding RNA SOX2OT: expression signature, splicing patterns, and emerging roles in pluripotency and tumorigenesis.
Mowla et al., Gorgān, Iran. In Front Genet, 2014
SOX2 overlapping transcript (SOX2OT) is a long non-coding RNA which harbors one of the major regulators of pluripotency, SOX2 gene, in its intronic region.
Co-motif discovery identifies an Esrrb-Sox2-DNA ternary complex as a mediator of transcriptional differences between mouse embryonic and epiblast stem cells.
Robson et al., Singapore, Singapore. In Stem Cells, 2013
Sox2 forms a heterodimer complex with Esrrb in ES cells to regulate transcriptional differences between mouse embryonic and epiblast stem cells.
Sox2+ stem cells contribute to all epithelial lineages of the tooth via Sfrp5+ progenitors.
Michon et al., Helsinki, Finland. In Dev Cell, 2012
Sox2 expression was regulated by the tooth initiation marker FGF8 and specific miRNAs, suggesting a fine-tuning to maintain homeostasis of the dental epithelium
Regulation of p27Kip1 by Sox2 maintains quiescence of inner pillar cells in the murine auditory sensory epithelium.
Zuo et al., Memphis, United States. In J Neurosci, 2012
This study demonistrated that Sox2 or p27(Kip1) expression is an effective approach to inducing proliferation of neonatal auditory inner pillar cells.
Cord blood-derived neuronal cells by ectopic expression of Sox2 and c-Myc.
Izpisua Belmonte et al., Barcelona, Spain. In Proc Natl Acad Sci U S A, 2012
Cord blood-derived neuronal cells by ectopic expression of Sox2 and c-Myc.
Regulation of XFGF8 gene expression through SRY (sex-determining region Y)-box 2 in developing Xenopus embryos.
Kim et al., Seoul, South Korea. In Reprod Fertil Dev, 2011
Suggest that SOX2 directly upregulates FGF8 gene expression in the early embryonic development of Xenopus.
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