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SRY-box containing gene 11

Sox11, END1, Vps11, PEP5
This intronless gene encodes a member of the SOX (SRY-related HMG-box) family of transcription factors involved in the regulation of embryonic development and in the determination of the cell fate. The encoded protein may act as a transcriptional regulator after forming a protein complex with other proteins. The protein may function in the developing nervous system and play a role in tumorigenesis. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: HAD, CAN, PCNA, Sox, V1a
Papers on Sox11
Diagnostic utility of SOX11 immunohistochemistry in differentiating cutaneous spread of mantle cell lymphoma from primary cutaneous B-cell lymphomas.
Schaffer et al., Saint Louis, United States. In J Cutan Pathol, Feb 2016
BACKGROUND: The GATA family of transcription factors is an essential regulator of cellular proliferation and differentiation.
SOX11 and HIG-2 are cross-regulated and affect growth in mantle cell lymphoma.
Ek et al., Lund, Sweden. In Leuk Lymphoma, Feb 2016
UNASSIGNED: The transcriptional factor SOX11 is a disease-defining antigen in mantle cell lymphoma (MCL) and absent in most non-malignant tissues.
Dead end1 is an essential partner of NANOS2 for selective binding of target RNAs in male germ cell development.
Saga et al., Yokohama, Japan. In Embo Rep, Jan 2016
We show that another RBP, Dead end1 (DND1), directly interacts with NANOS2 to load unique RNAs into the CNOT complex.
Search for regulatory factors of the pituitary-specific transcription factor PROP1 gene.
Kato et al., Japan. In J Reprod Dev, Jan 2016
Reporter assays for another 39 factors using the 3 kb upstream regions in CHO cells ultimately revealed that 8 factors, MSX2, PAX6, PIT1, PITX1, PITX2, RPF1, SOX8 and SOX11, but not RBP-J, regulate Prop1 expression.
Deletions and de novo mutations of SOX11 are associated with a neurodevelopmental disorder with features of Coffin-Siris syndrome.
McNeill et al., Ulm, Germany. In J Med Genet, Dec 2015
BACKGROUND: SOX11 is a transcription factor proposed to play a role in brain development.
The many faces of small B cell lymphomas with plasmacytic differentiation and the contribution of MYD88 testing.
Campo et al., Pittsburgh, United States. In Virchows Arch, Nov 2015
The workshop also highlighted how plasmacytic differentiation can occur in chronic lymphocytic leukemia/small lymphocytic lymphoma, follicular lymphoma, SOX11 negative MCL, and particularly in marginal zone lymphomas, all of which can cause diagnostic confusion with LPL.
Mantle cell lymphoma-a spectrum from indolent to aggressive disease.
Campo et al., Huddinge, Sweden. In Virchows Arch, Sep 2015
These were identified by SOX11 immunohistochemistry and found to carry CCND2 translocations and/or to express high levels of cyclin D2 mRNA.
Identification of potential biomarkers to differentially diagnose solid pseudopapillary tumors and pancreatic malignancies via a gene regulatory network.
Wang et al., Nanjing, China. In J Transl Med, 2014
43 new SPN-relevant genes were discovered, among which, we found hsa-miR-194 and hsa-miR-7 along with 7 transcription factors (TFs) such as SOX11, SMAD3 and SOX4 etc. could correctly differentiate SPN from PanNET, while hsa-miR-204 and 4 TFs such as SOX9, TCF7 and PPARD etc. were demonstrated as the potential markers for SPN versus PDAC.
Adherence of Candida sp. to host tissues and cells as one of its pathogenicity features.
Kurnatowski et al., Łódź, Poland. In Ann Parasitol, 2014
Various researchers specify a range of genes which contribute to adhesion, such as: CZF1, EFG1, TUP1, TPK1, TPK2, HGC1, RAS1, RIM101, VPS11, ECM1, CKA2, BCR1, BUD2, RSR1, IRS4, CHS2, SCS7, UBI4, UME6, TEC1 and GAT2.
Cytogenetic Study and Analysis of Protein Expression in Plasma Cell Myeloma with t(11;14)(q13;q32): Absence of BCL6 and SOX11, and Infrequent Expression of CD20 and PAX5.
Miura et al., In J Clin Exp Hematop, 2014
Cyclin D1, CD38, and BCL2 were detected in all patients; on the other hand, neither BCL6 nor SOX11 was detected in any of the evaluated patients.
Coffin-Siris syndrome and related disorders involving components of the BAF (mSWI/SNF) complex: historical review and recent advances using next generation sequencing.
Carey et al., In Am J Med Genet C Semin Med Genet, 2014
The identification of two additional causative genes (PHF6, SOX11) followed.
Are we a step forward with targeted agents in resolving the enigma of mantle cell lymphoma?
Vrbić et al., Niš, Serbia. In Contemp Oncol (pozn), 2013
Cyclin D1 and recently SOX11 are the hallmarks for this disease.
New syndrome of paraganglioma and somatostatinoma associated with polycythemia.
Zhuang et al., Bethesda, United States. In J Clin Oncol, 2013
An increase in the half-life of HIF2α was associated with upregulation of the hypoxia-related genes EPO, VEGFA, GLUT1, and END1 in tumors.
Sox11 modulates neocortical development by regulating the proliferation and neuronal differentiation of cortical intermediate precursors.
Li et al., Harbin, China. In Acta Biochim Biophys Sin (shanghai), 2012
Sox11 modulates neocortical development by regulating the proliferation and neuronal differentiation of cortical intermediate precursors
WT1 and Sox11 regulate synergistically the promoter of the Wnt4 gene that encodes a critical signal for nephrogenesis.
Vainio et al., Oulu, Finland. In Exp Cell Res, 2012
Sox11 represents a synergistic factor for WT1 in regulating the Wnt4 gene expression that is critical for nephrogenesis during kidney ontogeny.
Cis-regulatory control of corticospinal system development and evolution.
Sestan et al., New Haven, United States. In Nature, 2012
We find that SOX4 and SOX11 functionally compete with the repressor SOX5 in the transactivation of E4.
Sox11 modulates brain-derived neurotrophic factor expression in an exon promoter-specific manner.
Albers et al., Pittsburgh, United States. In J Neurosci Res, 2012
The results of this study indicted that cell type and contextual specificity of Sox11 in modulation of BDNF transcription.
SoxC transcription factors are required for neuronal differentiation in adult hippocampal neurogenesis.
Lie et al., München, Germany. In J Neurosci, 2012
SoxC transcription factors Sox11 and Sox4 target the promoters of genes that are induced upon neuronal differentiation of adult neural stem cells (NSCs).
Sequentially acting Sox transcription factors in neural lineage development.
Muhr et al., Stockholm, Sweden. In Genes Dev, 2012
genome-wide binding for Sox11, which have vital functions in ES cells, neural precursor cells (NPCs), and maturing neurons, respectively. (Sox11)
Two yeast mutants defective in endocytosis are defective in pheromone response.
Riezman et al., In Cell, 1986
end1 accumulates invaginations of the plasma membrane, and end2, an internal membrane-bound organelle.
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