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Sortilin-related VPS10 domain containing receptor 1

SorCS1, SorCS
This gene encodes one family member of vacuolar protein sorting 10 (VPS10) domain-containing receptor proteins. The VPS10 domain name comes from the yeast carboxypeptidase Y sorting receptor Vps10 protein. Members of this gene family are large with many exons but the CDS lengths are usually less than 3700 nt. Very large introns typically separate the exons encoding the VPS10 domain; the remaining exons are separated by much smaller-sized introns. These genes are strongly expressed in the central nervous system. Two of the five family members (sortilin and sortilin-related receptor) are synthesized as preproproteins; it is not yet known if this encoded protein is also a preproprotein. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: LR11, APP, HAD, AGE, CAN
Papers on SorCS1
Protein sorting gone wrong - VPS10P domain receptors in cardiovascular and metabolic diseases.
Willnow et al., Berlin, Germany. In Atherosclerosis, Jan 2016
In this review, we discuss current findings that uncovered some of the molecular mechanisms whereby sorting receptors, such as SORLA, sortilin, and SORCS1 control homeostasis in cardiovascular and metabolic tissues, and how they promote hypercholesterolemia, atherosclerosis, obesity, and diabetes, when being altered.
Using the Coriell Personalized Medicine Collaborative Data to conduct a genome-wide association study of sleep duration.
Christman et al., Camden, United States. In Am J Med Genet B Neuropsychiatr Genet, Dec 2015
In addition, we have identified novel candidate genes for involvement in sleep duration including SORCS1 and ELOVL2.
Sortilin-related receptor CNS expressed 2 (SorCS2) is localized to Bunina bodies in amyotrophic lateral sclerosis.
Wakabayashi et al., Hirosaki, Japan. In Neurosci Lett, Dec 2015
We immunohistochemically examined the spinal cord from patients with ALS and control subjects using antibodies against VPS10Ps (sortilin, SorLA, SorCS1, SorCS2 and SorCS3).
The A-B-C for SORting APP.
Andersen et al., Brisbane, Australia. In J Neurochem, Oct 2015
In their study, the authors provide novel insights into single-nucleotide polymorphisms associated with Alzheimer's disease and linked to the SorCS1 gene, toward a better understanding of the interaction of sorting receptor proteins which physically interact with the amyloid-beta protein precursor (APP).
Candidate genes for Alzheimer's disease are associated with individual differences in plasma levels of beta amyloid peptides in adults with Down syndrome.
Lee et al., New York City, United States. In Neurobiol Aging, Oct 2015
For Aβ42 levels, the strongest gene-wise association was found for a single nucleotide polymorphism (SNP) on CAHLM1; for Aβ40 levels, the strongest gene-wise associations were found for SNPs in IDE and SOD1, while the strongest gene-wise associations with levels of the Aβ42/Aβ40 ratio were found for SNPs in SORCS1.
SorCS1 variants and amyloid precursor protein (APP) are co-transported in neurons but only SorCS1c modulates anterograde APP transport.
Kins et al., Hamburg, Germany. In J Neurochem, Oct 2015
The sorting receptor SorCS1 has been genetically linked to AD, but the underlying molecular mechanisms are poorly understood.
The Sorting Receptor SorCS1 Regulates Trafficking of Neurexin and AMPA Receptors.
de Wit et al., Los Angeles, United States. In Neuron, Sep 2015
Here, we identify the sorting receptor SorCS1 as a key regulator of synaptic receptor trafficking.
The role of the retromer complex in aging-related neurodegeneration: a molecular and genomic review.
Reitz, New York City, United States. In Mol Genet Genomics, Apr 2015
In addition to their functions in protein trafficking, the members of the Vps10 receptor family (sortilin, SorL1, SorCS1, SorCS2, and SorCS3) modulate neurotrophic signaling pathways.
SORCS1 is necessary for normal insulin secretory granule biogenesis in metabolically stressed β cells.
Attie et al., In J Clin Invest, 2014
We previously positionally cloned Sorcs1 as a diabetes quantitative trait locus.
The genetic basis of obesity-associated type 2 diabetes (diabesity) in polygenic mouse models.
Schürmann et al., Potsdam, Germany. In Mamm Genome, 2014
Outcross populations of these models have been employed in the genome-wide search for mouse diabetes genes, and have led to positional cloning of the strong candidates Pctp, Tbc1d1, Zfp69, and Ifi202b (NZO-derived obesity) and Sorcs1, Lisch-like, Tomosyn-2, App, Tsc2, and Ube2l6 (obesity caused by the ob or db mutation).
Effects of genetic variation on the dynamics of neurodegeneration in Alzheimer's disease.
Alzheimer's Disease Neuroimaging Initiative et al., In Conf Proc Ieee Eng Med Biol Soc, 2013
After false discovery rate correction, we observed 53 significant associations between SNPs and our imaging features, including associations of ventricular enlargement with SNPs on estrogen receptor 1 (ESR1) and sortilin-related VPS10 domain containing receptor 1 (SORCS1), hippocampal atrophy with SNPs on ESR1, and cerebral atrophy with SNPs on transferrin (TF) and amyloid beta precursor protein (APP).
Sortilins in neurotrophic factor signaling.
Vaegter et al., Århus, Denmark. In Handb Exp Pharmacol, 2013
The sortilin family of Vps10p-domain receptors includes sortilin, SorLA, and SorCS1-3.
Vps10 family proteins and the retromer complex in aging-related neurodegeneration and diabetes.
Gandy et al., New York City, United States. In J Neurosci, 2012
Members of the vacuolar protein sorting 10 (Vps10) family of receptors (including sortilin, SorL1, SorCS1, SorCS2, and SorCS3) play pleiotropic functions in protein trafficking and intracellular and intercellular signaling in neuronal and non-neuronal cells.
SORCS1 and APOE polymorphisms interact to confer risk for late-onset Alzheimer's disease in a Northern Han Chinese population.
Tan et al., Qingdao, China. In Brain Res, 2012
Our data suggested that SORCS1 was in interaction with APOE in the development of late-onset Alzheimer's disease in a Northern Han Chinese population
Evaluation of four novel genetic variants affecting hemoglobin A1c levels in a population-based type 2 diabetes cohort (the HUNT2 study).
Njølstad et al., Bergen, Norway. In Bmc Med Genet, 2010
the 4 recently reported SNPs,located near BNC2, SORCS1, GSC and WDR72 loci, affecting glycemic control in type 1 diabetes had no apparent effect on HbA1c in type 2 diabetes; but, for SORCS1 SNP, findings do not rule out possible relationship with HbA1c
Impact of genetic variation in SORCS1 on memory retention.
Mayeux et al., New York City, United States. In Plos One, 2010
suggest that genetic variation in SORCS1 is associated with memory performance
Diabetes-associated SorCS1 regulates Alzheimer's amyloid-beta metabolism: evidence for involvement of SorL1 and the retromer complex.
Gandy et al., New York City, United States. In J Neurosci, 2010
Dysfunction of SorCS1 may contribute to both the amyloid precursor protein/amyloidbeta disturbance underlying Alzheimer disease and the insulin/glucose disturbance underlying diabetes mellitus.
A novel method for testing association of multiple genetic markers with a multinomial trait.
Guo et al., Houston, United States. In Proc Am Stat Assoc, 2010
Applying the method to study 32 genes in our Mexican-American samples for association with prediabetes through either impaired glucose tolerance (IGT) or impaired fasting glucose (IFG), we found 3 genes (SORCS1, AMPD1, PPAR) associated with both IGT and IFG, while 5 genes (AMPD2, PRKAA2, C5, TCF7L2, ITR) with the IGT mechanism only and 6 genes (CAPN10, IL4,NOS3, CD14, GCG, SORT1) with the IFG mechanism only.
A genome-wide association study identifies a novel major locus for glycemic control in type 1 diabetes, as measured by both A1C and glucose.
Diabetes Control and Complications Trial/Epidemiology of Diabetes Interventions and Complications Research Group et al., Toronto, Canada. In Diabetes, 2010
SNP which is nearest to SORCS1 is highly significantly associated with glycemic control in individuals with type 1 diabetes
Positional cloning of Sorcs1, a type 2 diabetes quantitative trait locus.
Attie et al., Madison, United States. In Nat Genet, 2006
identification of the Sorcs1 gene provides insight into the pathway underlying the pathophysiology of obesity-induced type 2 diabetes mellitus
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