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The hormone somatostatin has active 14 aa and 28 aa forms that are produced by alternate cleavage of the single preproprotein encoded by this gene. Somatostatin is expressed throughout the body and inhibits the release of numerous secondary hormones by binding to high-affinity G-protein-coupled somatostatin receptors. This hormone is an important regulator of the endocrine system through its interactions with pituitary growth hormone, thyroid stimulating hormone, and most hormones of the gastrointestinal tract. Somatostatin also affects rates of neurotransmission in the central nervous system and proliferation of both normal and tumorigenic cells. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: CAN, HAD, Insulin, Parvalbumin, SPINK5
Papers using somatostatin antibodies
A phase I/IIA study of AGS-PSCA for castration-resistant prostate cancer
Saeki Norihisa et al., In Anatomy & Cell Biology, 2011
... anti-PSCA, rabbit anti-insulin (sc-9186, Santa Cruz Biotechnology), rabbit anti-glucagon (ab18461, Abcam Japan, Tokyo, Japan), rabbit anti-somatostatin (A0566, Dako Japan, Tokyo, Japan) and ...
Identification of calcineurin regulated phosphorylation sites on CRHSP-24
Kumar Ujendra et al., In Journal of Molecular Signaling, 2008
... Somatostatin-14 was obtained from Bachem, Torrance, CA ...
An immunohistochemical study of the pancreatic endocrine cells of the nude mouse, Balb/c-nu/nu
Ku S.K. et al., In European Journal of Histochemistry : EJH, 2005
... SomatostatinA0566DAKO corp., Carpenteria, USA ...
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Papers on somatostatin
Synthesis, Characterization, and In Vitro Evaluation of New (99m)Tc/Re(V)-Cyclized Octreotide Analogues: An Experimental and Computational Approach.
Jurisson et al., Columbia, United States. In Inorg Chem, Feb 2016
UNASSIGNED: Radiolabeled proteolytic degradation-resistant somatostatin analogues have been of long-standing interest as cancer imaging and radiotherapy agents for targeting somatostatin receptor-positive tumors.
Pros and cons in endocrine practice: pre-surgical treatment with somatostatin analogues in acromegaly.
Bollerslev et al., Milano, Italy. In Endocrine, Feb 2016
UNASSIGNED: The aim of this commentary is to balance the pros and cons for pre-surgical SSA treatment in a modern perspective ending up with a pragmatic recommendation for treatment based on the current evidence and expertise of the authors.
Neuropeptide Y input to the rat basolateral amygdala complex and modulation by conditioned fear.
Urban et al., North Chicago, United States. In J Comp Neurol, Feb 2016
NPY innervation of the BLA was assessed in rats by examining the degree of NPY co-expression within interneurons or catecholaminergic fibers using somatostatin and tyrosine hydroxylase (TH) or dopamine β-hydroxylase (DβH), respectively.
BMP-6 modulates somatostatin effects on luteinizing hormone production by gonadrotrope cells.
Makino et al., Okayama, Japan. In Peptides, Feb 2016
UNASSIGNED: The effects of somatostatin analogs and roles of BMP-6 in the regulation of luteinizing hormone (LH) secretion were investigated using mouse gonadotrope LβT2 cells.
[(177)Lu-DOTA(0),Tyr(3)]-octreotate in the treatment of midgut neuroendocrine tumors.
Yao et al., Houston, United States. In Future Oncol, Feb 2016
Peptide receptor radionuclide therapy utilizes somatostatin analogs conjugated to radioactive isotopes in order to deliver high doses of radiation directly to tumor cells, which express somatostatin receptors.
Targeting "undruggable"proteins: design of synthetic Cyclopeptides.
Marasco et al., Napoli, Italy. In Curr Med Chem, Feb 2016
Typically macrocycles are 500-2000 Da, having 12-membered or more ring architecture: they don't obey the Lipinski's rule but, for them, nature offers many examples as therapeutic agents, such as erythromycin (antibiotic), cyclosporin (immunosuppressant) and somatostatin (hormone).
Octreotide and Lanreotide in Gastroenteropancreatic Neuroendocrine Tumors.
Iyer et al., Buffalo, United States. In Curr Oncol Rep, Jan 2016
They often secrete vasoactive substances resulting in carcinoid syndrome and the tumor cells exclusively express somatostatin receptors.
Management of pancreatic trauma: A pancreatic surgeon's point of view.
Guglielmi et al., Verona, Italy. In Pancreatology, Jan 2016
The majority of pancreatic traumas are managed by medical treatment (parenteral nutrition, antibiotic therapy and somatostatin analogues), haemostasis, debridement of devitalised tissue and closed external drainage.
Everolimus for the treatment of advanced, non-functional neuroendocrine tumours of the lung or gastrointestinal tract (RADIANT-4): a randomised, placebo-controlled, phase 3 study.
RAD001 in Advanced Neuroendocrine Tumours et al., Houston, United States. In Lancet, Jan 2016
Patients were stratified by tumour origin, performance status, and previous somatostatin analogue treatment.
Tumour-induced osteomalacia: a literature review and a case report.
Kacergius et al., Vilnius, Lithuania. In World J Surg Oncol, Dec 2015
Finding the tumour can be a major diagnostic challenge and may involve total body magnetic resonance imaging, computed tomography and scintigraphy using radiolabelled somatostatin analogue.
Combined ligand-observe (19)F and protein-observe (15)N,(1)H-HSQC NMR suggests phenylalanine as the key Δ-somatostatin residue recognized by human protein disulfide isomerase.
Howard et al., Canterbury, United Kingdom. In Sci Rep, Dec 2015
We report a detailed study of specificity, interaction and dissociation constants (Kd) of the peptide-ligand Δ-somatostatin (AGSKNFFWKTFTSS) binding to hPDI using (19)F ligand-observe and (15)N,(1)H-HSQC protein-observe NMR methods.
Cholangiocytes derived from human induced pluripotent stem cells for disease modeling and drug validation.
Vallier et al., Cambridge, United Kingdom. In Nat Biotechnol, Aug 2015
CLCs show functional characteristics of cholangiocytes, including bile acids transfer, alkaline phosphatase activity, γ-glutamyl-transpeptidase activity and physiological responses to secretin, somatostatin and vascular endothelial growth factor.
The Treatment of Cushing's Disease.
Colao et al., Napoli, Italy. In Endocr Rev, Aug 2015
Among this group of drugs, the dopamine agonist cabergoline and the somatostatin analog pasireotide result in disease remission in a consistent subgroup of patients with CD.
Urocortin3 mediates somatostatin-dependent negative feedback control of insulin secretion.
Huising et al., Davis, United States. In Nat Med, Jul 2015
Here we demonstrate that Ucn3 is stored and co-released with insulin and potentiates glucose-stimulated somatostatin secretion via cognate receptors on delta cells.
Branch-specific dendritic Ca(2+) spikes cause persistent synaptic plasticity.
Gan et al., New York City, United States. In Nature, May 2015
When somatostatin-expressing interneurons are inactivated, different motor tasks frequently induce Ca(2+) spikes on the same branches.
Synaptic relationship between somatostatin- and neurokinin-1 receptor-immunoreactive neurons in the pre-Bötzinger complex of rats.
Liu et al., Xi'an, China. In J Neurochem, 2012
This study provides structural evidence that SST immunoreactivity in the pre-BotC is highly expressed in somas, terminals, and primary dendrites, and overlapped with small fusiform NK1R-ir neurons.
PDZ domain-containing 1 (PDZK1) protein regulates phospholipase C-β3 (PLC-β3)-specific activation of somatostatin by forming a ternary complex with PLC-β3 and somatostatin receptors.
Suh et al., South Korea. In J Biol Chem, 2012
PDZ domain-containing 1 (PDZK1) protein regulates phospholipase C-beta3 (PLC-beta3)-specific activation of somatostatin by forming a ternary complex with PLC-beta3 and somatostatin receptors.
Somatostatin and neuropeptide Y neurons undergo different plasticity in parahippocampal regions in kainic acid-induced epilepsy.
Sperk et al., Innsbruck, Austria. In J Neuropathol Exp Neurol, 2012
Surviving somatostatin interneurons display increased mRNA levels at late intervals (3 months) after kainic acid-induced epilepsy.
Immunohistochemical identification and localisation of gastrin and somatostatin in endocrine cells of human pyloric gastric mucosa.
Lewandowska et al., Białystok, Poland. In Folia Morphol (warsz), 2012
Investigation of the healthy human pylorus shows characteristic distribution of cells that react with antisera to gastrin and somatostatin.
Somatostatin modulates insulin-degrading-enzyme metabolism: implications for the regulation of microglia activity in AD.
Marini et al., Roma, Italy. In Plos One, 2011
role played by somatostatin in preventing Abeta accumulation by partially restoring IDE activity
More papers using somatostatin antibodies
Direct inhibitory effects of a somatostatin analog, SMS 201-995, on AR4-2J cell proliferation via pertussis toxin-sensitive guanosine triphosphate-binding protein-independent mechanism
Morisset Jean et al., In International Journal of Endocrinology, 1988
... Somatostatin-14 (SS-14) was purchased from Bachem Bioscience (King of Prussia, ...
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