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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Dec 2016.

Grainyhead-like 3

Som, Grhl3, Get1
This gene encodes a member of the grainyhead family of transcription factors. The encoded protein may function as a transcription factor during development, and has been shown to stimulate migration of endothelial cells. Multiple transcript variants encoding distinct isoforms have been identified for this gene.[provided by RefSeq, Aug 2010] (from NCBI)
Top mentioned proteins: somatostatin, CAN, HAD, endothelin-1, V1a
Papers on Som
Irf6 directly regulates Klf17 in zebrafish periderm and Klf4 in murine oral epithelium, and dominant-negative KLF4 variants are present in patients with cleft lip and palate.
Cornell et al., Wuhan, China. In Hum Mol Genet, Jan 2016
Mutations in IRF6 (Interferon Regulatory Factor 6) and GRHL3 (Grainyhead-like 3) cause Van der Woude syndrome, which includes CL/P.
Recent discoveries concerning the involvement of transcription factors from the Grainyhead-like family in cancer.
Wilanowski et al., Warsaw, Poland. In Exp Biol Med (maywood), Nov 2015
The Grainyhead-like (GRHL) family of transcription factors has three mammalian members, which are currently termed Grainyhead-like 1 (GRHL1), Grainyhead-like 2 (GRHL2), and Grainyhead-like 3 (GRHL3).
Selective astrocytic endothelin-1 overexpression contributes to dementia associated with ischemic stroke by exaggerating astrocyte-derived amyloid secretion.
Chung et al., Hong Kong, Hong Kong. In J Cereb Blood Flow Metab, Oct 2015
Therefore, GET-1 mice were challenged with tMCAO to determine its effect on neurologic and cognitive deficit.
Toward an orofacial gene regulatory network.
Schutte et al., East Lansing, United States. In Dev Dyn, Oct 2015
Furthermore, IRF6 regulates GRHL3 and rare variants in this downstream target can also lead to Van der Woude syndrome.
Identification of a Novel Proto-oncogenic Network in Head and Neck Squamous Cell Carcinoma.
Darido et al., Australia. In J Natl Cancer Inst, Sep 2015
BACKGROUND: The developmental transcription factor Grainyhead-like 3 (GRHL3) plays a critical tumor suppressor role in the mammalian epidermis through direct regulation of PTEN and the PI3K/AKT/mTOR signaling pathway.
Targeted Overexpression of Astrocytic Endothelin-1 Attenuates Neuropathic Pain by Upregulating Spinal Excitatory Amino Acid Transporter-2.
Cheung et al., Hong Kong, Hong Kong. In J Mol Neurosci, Sep 2015
We previously demonstrated that endogenous endothelin-1 (ET-1) inhibits pathological pain in a transgenic mouse model with astrocyte-specific ET-1 overexpression (GET-1 mice); however, the underlying mechanism is unclear.
Loss-of-function de novo mutations play an important role in severe human neural tube defects.
Kibar et al., Montréal, Canada. In J Med Genet, Jul 2015
We also identified one nonsense DNM in PAX3 and two potentially causative missense DNMs in GRHL3 and PTPRS.
Comparative mtDNA analyses of three sympatric macropodids from a conservation area on the Huon Peninsula, Papua New Guinea.
Husband et al., United States. In Mitochondrial Dna, Jun 2015
UNASSIGNED: Matschie's tree kangaroo (Dendrolagus matschiei), New Guinea pademelon (Thylogale browni), and small dorcopsis (Dorcopsulus vanheurni) are sympatric macropodid taxa, of conservation concern, that inhabit the Yopno-Urawa-Som (YUS) Conservation Area on the Huon Peninsula, Papua New Guinea.
A LncRNA-MAF:MAFB transcription factor network regulates epidermal differentiation.
Khavari et al., Stanford, United States. In Dev Cell, Apr 2015
ChIP-seq analysis demonstrated MAF:MAFB binding to known epidermal differentiation TF genes whose expression they controlled, including GRHL3, ZNF750, KLF4, and PRDM1.
Early oral feeding following thoracolaparoscopic oesophagectomy for oesophageal cancer.
Li et al., Zhengzhou, China. In Eur J Cardiothorac Surg, Feb 2015
RESULTS: The mean preoperative half gastric emptying time (GET1/2) was 66.4 ± 38.4 min for all 68 patients, and the mean GET1/2 at postoperative day (POD) 1 and POD 7 was statistically significantly shorter than preoperative GET1/2 (23.9 ± 15.7 min and 24.1 ± 7.9 min, respectively, both P-values <0.001).
A GRHL3-regulated repair pathway suppresses immune-mediated epidermal hyperplasia.
Andersen et al., In J Clin Invest, 2014
Here, we determined that the prodifferentiation transcription factor grainyhead-like 3 (GRHL3), which is essential during epidermal development, is dispensable for adult skin homeostasis, but required for barrier repair after adult epidermal injury.
Endothelin-1 overexpression exacerbate experimental allergic encephalomyelitis.
Chan et al., Hong Kong, Hong Kong. In J Neuroimmunol, 2014
METHODS: EAE is induced in transgenic mice overexpressing endothelial ET-1 (TET-1), transgenic mice overexpressing astrocytic ET-1 (GET-1) and non-transgenic (NTg) mice by immunization with myelin oligodendrocyte glycoprotein (MOG)35-55 peptide.
Grainyhead-like 3 regulation of endothelin-1 in the pharyngeal endoderm is critical for growth and development of the craniofacial skeleton.
Jane et al., Australia. In Mech Dev, 2014
Here, we demonstrate that morpholino (MO)-mediated knockdown in zebrafish of the highly conserved transcription factor grainyhead-like 3 (grhl3), which is selectively expressed in the pharyngeal endoderm, leads to severe hypoplasia of the lower jaw cartilages.
Progenitor function in self-renewing human epidermis is maintained by the exosome.
Sen et al., San Diego, United States. In Cell Stem Cell, 2012
EXOSC9 promotes self-renewal and prevents premature differentiation by maintaining transcript levels of a transcription factor necessary for epidermal differentiation, GRHL3, at low levels through mRNA degradation.
Targeting of the tumor suppressor GRHL3 by a miR-21-dependent proto-oncogenic network results in PTEN loss and tumorigenesis.
Jane et al., Australia. In Cancer Cell, 2011
The developmental transcription factor Grhl3 is a potent tumor suppressor of squamous cell carcinoma in mice.
The transcription factor Grainyhead like 3 (GRHL3) affects endothelial cell apoptosis and migration in a NO-dependent manner.
Haendeler et al., Düsseldorf, Germany. In Biochem Biophys Res Commun, 2011
loss of GRHL3 may result in endothelial dysfunction in vivo.
Structural basis for tail-anchored membrane protein biogenesis by the Get3-receptor complex.
Sinning et al., Frankfurt am Main, Germany. In Science, 2011
crystal structures of Get3 in complex with cytosolic domain of Get1 and Get2 in different states; data show Get1 and Get2 can bind simultaneously to Get3;docking to Get1/2 complex allows for conformational change in Get3 required for TA protein insertion
ABI3 and PIL5 collaboratively activate the expression of SOMNUS by directly binding to its promoter in imbibed Arabidopsis seeds.
Choi et al., Taejŏn, South Korea. In Plant Cell, 2011
ABI3 and PIL5 collaboratively activate the expression of SOM mRNA by directly binding to and interacting with each other at the SOM promoter.
The unique and cooperative roles of the Grainy head-like transcription factors in epidermal development reflect unexpected target gene specificity.
Jane et al., Melbourne, Australia. In Dev Biol, 2011
Both GRHL2 and GRHL3 bind to and regulate expression of the wound repair gene Rho GEF 19, but regulation of the barrier forming gene, Transglutaminase 1 (TGase1), is unique to GRHL3.
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