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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Dec 2016.

Spermatogenesis and oogenesis specific basic helix-loop-helix 1

Sohlh1, GM110
Top mentioned proteins: CAN, Nobox, l-3, ACID, GDF9
Papers on Sohlh1
Gap junctions are essential for murine primordial follicle assembly immediately before birth.
Zhang et al., Beijing, China. In Reproduction, Feb 2016
In addition, the expression of ovarian somatic cell (OSC)-specific genes, such as Notch2, Foxl2 and Irx3, was negatively affected by GJC blockers, whereas oocyte-related genes, such as Ybx2, Nobox and Sohlh1, were hardly affected, implying that the establishment of GJC during this period may be more important to OSCs than to oocytes.
Mammalian target of rapamycin complex 1 (mTORC1) Is required for mouse spermatogonial differentiation in vivo.
Geyer et al., Greenville, United States. In Dev Biol, Dec 2015
In addition, rapamycin also blocked the RA-induced translational activation of mRNAs encoding KIT, SOHLH1, and SOHLH2 without affecting expression of STRA8.
Homozygous loss-of-function mutations in SOHLH1 in patients with nonsyndromic hypergonadotropic hypogonadism.
Lupski et al., Houston, United States. In J Clin Endocrinol Metab, May 2015
RESULTS: Exome sequencing analysis revealed two different truncating mutations in the same gene: SOHLH1 c.705delT (p.Pro235fs*4) and SOHLH1 c.27C>G (p.Tyr9stop).
Transcription factor SOHLH1 potentially associated with primary ovarian insufficiency.
Chen et al., Jinan, China. In Fertil Steril, Feb 2015
OBJECTIVE: To investigate whether gene variants of SOHLH1 exist in Chinese and Serbian patients with primary ovarian insufficiency (POI).
Association of genetic variants in SOHLH1 and SOHLH2 with non-obstructive azoospermia risk in the Chinese population.
Cao et al., Hefei, China. In Eur J Obstet Gynecol Reprod Biol, 2015
OBJECTIVE: Spermatogenesis and oogenesis specific basic helix-loop-helix 1 (SOHLH1) and spermatogenesis and oogenesis specific basic helix-loop-helix 2 (SOHLH2) play essential roles for both spermatogenesis and oogenesis.
Life-long in vivo cell-lineage tracing shows that no oogenesis originates from putative germline stem cells in adult mice.
Liu et al., Göteborg, Sweden. In Proc Natl Acad Sci U S A, 2015
By in vivo tracing of oocytes and follicles in the Sohlh1-CreER(T2);R26R and Foxl2-CreER(T2);mT/mG mouse models, respectively, we have shown that the initial pool of oocytes is the only source of germ cells throughout the life span of the mice and that no adult oogenesis ever occurs under physiological conditions.
Immunohistochemical Study of Expression of Sohlh1 and Sohlh2 in Normal Adult Human Tissues.
Hao et al., Jinan, China. In Plos One, 2014
The expression pattern of Sohlh1 (spermatogenesis and oogenesis specific basic helix-loop-helix 1) and Sohlh2 in mice has been reported in previous studies.
Adverse Effects of High Concentrations of Fluoride on Characteristics of the Ovary and Mature Oocyte of Mouse.
Zhang et al., China. In Plos One, 2014
The expression of genes, including Dazl, Stra8, Nobox, Sohlh1, and ZP3 gene, associated with oocyte formation were much lower in the experimental group as compared with the control group.
SOHLH1 and SOHLH2 directly down-regulate STIMULATED BY RETINOIC ACID 8 (STRA8) expression.
Farini et al., Roma, Italy. In Cell Cycle, 2014
In this study, we demonstrate a direct negative control of SOHLH1 and SOHLH2, 2 germ cell specific bHLH transcription factors, on Stra8 expression.
Lhx8 regulates primordial follicle activation and postnatal folliculogenesis.
Rajkovic et al., Pittsburgh, United States. In Bmc Biol, 2014
Previously, we discovered that global knockouts of germ cell-specific transcriptional co-regulators Sohlh1, Sohlh2, Lhx8, and Nobox, cause rapid oocyte loss and ovarian failure.
Transcriptional control of spermatogonial maintenance and differentiation.
Wilkinson et al., San Diego, United States. In Semin Cell Dev Biol, 2014
Several transcription factors have been identified that promote spermatogonial differentiation (DMRT1, NGN3, SOHLH1, SOHLH2, SOX3, and STAT3); some of these may influence the decision of an SSC to commit to differentiate while others may promote later spermatogonial differentiation steps.
Transcriptional control of KIT gene expression during germ cell development.
Rossi, Roma, Italy. In Int J Dev Biol, 2012
Variable mechanisms, involving different germ cell-specific transcription factors, are operating in the various developmental stages: SOX2 and SOHLH1/2 act as direct positive regulators in PGCs and in postnatal spermatogonia, respectively, whereas PLZF suppresses KIT expression in spermatogonial stem cells.
Oogenesis: transcriptional regulators and mouse models.
Rajkovic et al., Pittsburgh, United States. In Mol Cell Endocrinol, 2012
These transcriptional regulators include: Foxo3, Foxl2, Figla, Lhx8, Nobox, Sohlh1 and Sohlh2.
SOHLH1 and SOHLH2 coordinate spermatogonial differentiation.
Rajkovic et al., Pittsburgh, United States. In Dev Biol, 2012
SOHLH1 and SOHLH2 suppress genes involved in spermatogonial stem cell maintenance, and induce genes important for spermatogonial differentiation.
Mutations in SOHLH1 gene associate with nonobstructive azoospermia.
Shim et al., Seoul, South Korea. In Hum Mutat, 2010
Findings indicate that a splice-acceptor site mutation that probably causes a nonfunctional SOHLH1 protein results in nonobstructive azoospermia by the lack of normal spermatogenesis.
Oocyte-specific genes affect folliculogenesis, fertilization, and early development.
Dean et al., Bethesda, United States. In Semin Reprod Med, 2007
Mouse transgenesis has been particularly useful in defining germ-cell specific genes and their roles in folliculogenesis (e.g., DAZLA, FIGLA, NOBOX, SOHLH1, YBX2, CPEB1, GDF9), fertilization (e.g., ZP1, ZP2, ZP3), and preimplantation embryonic development (e.g., NPM2, ZAR1, NALP5, DPPA3).
New insights into male gametogenesis: what about the spermatogonial stem cell niche?
Dadoune, Paris, France. In Folia Histochem Cytobiol, 2006
Plzf, a transcriptional repressor protein, and TAF-4b, a germ cell specific component of the RNA polymerase complex, are considered to be essential for SSC renewal, whereas the transcription factors Sohlh1 and 2 appear to be crucial for spermatogonial differentiation.
Sohlh1 is essential for spermatogonial differentiation.
Rajkovic et al., Houston, United States. In Dev Biol, 2006
Sohlh1 represents the first testis-specific bHLH transcription factor that is essential for spermatogonial differentiation.
Oogenesis requires germ cell-specific transcriptional regulators Sohlh1 and Lhx8.
Rajkovic et al., Houston, United States. In Proc Natl Acad Sci U S A, 2006
Sohlh1 and Lhx8 are two germ cell-specific, critical regulators of oogenesis
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