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Suppressor of cytokine signaling 3

SOCS3, cis-3, suppressor of cytokine signaling 3
This gene encodes a member of the STAT-induced STAT inhibitor (SSI), also known as suppressor of cytokine signaling (SOCS), family. SSI family members are cytokine-inducible negative regulators of cytokine signaling. The expression of this gene is induced by various cytokines, including IL6, IL10, and interferon (IFN)-gamma. The protein encoded by this gene can bind to JAK2 kinase, and inhibit the activity of JAK2 kinase. Studies of the mouse counterpart of this gene suggested the roles of this gene in the negative regulation of fetal liver hematopoiesis, and placental development. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: CIs, STAT3, Interleukin-6, V1a, CAN
Papers using SOCS3 antibodies
Adipose triglyceride lipase deficiency causes tissue-specific changes in insulin signaling
Alquier Thierry, In PLoS ONE, 2008
... The SOCS3 construct was linearized with Stu I and injected into pronuclei of fertilized eggs from FVB mice in the Transgenic Core Facility at Beth ...
Intranasal administration of alpha interferon reduces seasonal influenza A virus morbidity in ferrets.
Zhang Linqi, In PLoS ONE, 2008
... Antibodies against p-STAT1, p-STAT2, p-STAT3, STAT1, STAT3, HA, SOCS1, and SOCS3 were purchased from Cell signaling.
Distinct impaired regulation of SOCS3 and long and short isoforms of the leptin receptor in visceral and subcutaneous fat of lean and obese women.
Lucia Alejandro, In PLoS ONE, 2005
... The polyclonal rabbit anti-human SOCS3 antibody was obtained from Santa Cruz Biotechnology (Santa Cruz, CA, USA) ...
Suppressor of cytokine Signaling-3 inhibits interleukin-1 signaling by targeting the TRAF-6/TAK1 complex
Li Jun, In PLoS ONE, 2005
... SOCS3 primary antibodies were from Abcam (Cambridge, MA) and Cell ...
Direct effects of leptin on brown and white adipose tissue
Calbet Jose A. L., In PLoS ONE, 1996
... phosphorylated (p)-Ser473-Akt, p-Ser727-signal transducer and activator of transcription factor 3 (pSer727-STAT3) and suppressor of cytokine signaling 3 (SOCS3) were from Cell Signaling Technology (Danvers, MA, USA), ...
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Papers on SOCS3
Leptin signalling pathways in hypothalamic neurons.
Kim et al., Seoul, South Korea. In Cell Mol Life Sci, Feb 2016
These include SOCS3, tyrosine phosphatase PTP1B, and inflammatory signaling pathways such as IKK-NFκB and JNK signaling, and ER stress-mitochondrial signaling.
Tetraspanin CD37 protects against the development of B cell lymphoma.
van Spriel et al., In J Clin Invest, Feb 2016
We discovered that CD37 interacts with suppressor of cytokine signaling 3 (SOCS3); therefore, absence of CD37 drives tumor development through constitutive activation of the IL-6 signaling pathway.
Restoration of Visual Function by Enhancing Conduction in Regenerated Axons.
He et al., Boston, United States. In Cell, Feb 2016
Here, in both juvenile and adult mice, we show that either PTEN and SOCS3 co-deletion, or co-overexpression of osteopontin (OPN)/insulin-like growth factor 1 (IGF1)/ciliary neurotrophic factor (CNTF), induces regrowth of retinal axons and formation of functional synapses in the superior colliculus (SC) but not significant recovery of visual function.
Exposure to TiO2 Nanoparticles Induces Immunological Dysfunction in Mouse Testitis.
Wang et al., Huaiyin, China. In J Agric Food Chem, Feb 2016
Furthermore, these were associated with decreased expression of Tyro3 (-18.16 to -66.6%), Axl (-14.7 to -57.99%), Mer (-7.98 to -72.62%), and IκB (-11.25 to -63.16%), suppression of cytokine signaling (SOCS) 1 (-21.99 to -73.8%) and SOCS3 (-8.11 to -34.86%), and increased expression of Toll-like receptor (TLR)-3 (21.4-156.03%),
Downregulation of microRNA-218 relieves neuropathic pain by regulating suppressor of cytokine signaling 3.
Zhao et al., Changchun, China. In Int J Mol Med, Feb 2016
A dual-luciferase reporter assay, RT-qPCR, and western blot analysis results demonstrated that miR-218 directly targeted the 3'-UTR of the suppressor of cytokine signaling 3 (SOCS3) and regulated mRNA and protein expression of SOCS3.
Investigation of FIH-1 and SOCS3 expression in KRAS mutant and wild-type patients with colorectal cancer.
Javadi et al., Qazvīn, Iran. In Tumour Biol, Feb 2016
Next, we investigated the expression of two tumor suppressor genes, factor-inhibiting hypoxia-inducible factor 1 (FIH-1) and suppressor of cytokine signaling (SOCS3), in both KRAS mutant and wild-type groups and looked for any correlation between their expression and clinicopathological parameters.
IL-6 promotes an increase in human mast cell numbers and reactivity through suppression of suppressor of cytokine signaling 3.
Metcalfe et al., Bethesda, United States. In J Allergy Clin Immunol, Feb 2016
Epigenetic changes in suppressor of cytokine signaling 3 (SOCS3) were determined by using methylation-specific PCR.
Reaching the brain: Advances in optic nerve regeneration.
Goldberg et al., In Exp Neurol, Jan 2016
More recently, some degree of regeneration has been achieved through the optic nerve itself by factors associated with intraocular inflammation (oncomodulin) or by altering levels of particular transcription factors (Klf-4, -9, c-myc), cell-intrinsic suppressors of axon growth (PTEN, SOCS3), receptors to cell-extrinsic inhibitors of axon growth (Nogo receptor, LAR, PTP-σ) or the intracellular signaling pathway activated by these receptors (RhoA).
Resistin's, obesity and insulin resistance: the continuing disconnect between rodents and humans.
Yang et al., Chongqing, China. In J Endocrinol Invest, Jan 2016
Resistin plays a causative role in the development of insulin resistance in rodents via 5' AMP-activated protein kinase (AMPK)-dependent and AMPK-independent suppressor of cytokine signaling-3 (SOCS-3) signaling.
SOCS2: physiological and pathological functions.
Haan et al., Luxembourg, Luxembourg. In Front Biosci (elite Ed), Dec 2015
The most studied family members, CIS, SOCS1, SOCS2 and SOCS3 are important regulators of the JAK-STAT pathway.
The role of probiotics in the prevention of severe infections following abdominal surgery.
Kotzampassi et al., Thessaloníki, Greece. In Int J Antimicrob Agents, Dec 2015
Recent experimental studies have demonstrated that probiotics may decrease expression of the SOCS3 gene, which encodes the protein SOCS3 that suppresses cytokine production, implying a direct interaction of probiotics with the innate immune system.
The histone lysine methyltransferase KMT2D sustains a gene expression program that represses B cell lymphoma development.
Wendel et al., New York City, United States. In Nat Med, Oct 2015
Notably, other KMT2D target genes include frequently mutated tumor suppressor genes such as TNFAIP3, SOCS3 and TNFRSF14.
Out-of-Sequence Signal 3 Paralyzes Primary CD4(+) T-Cell-Dependent Immunity.
Murphy et al., Sacramento, United States. In Immunity, Sep 2015
This suppression targeted naive CD4(+) but not CD8(+) T cells and was mediated through transient suppressor of cytokine signaling-3 (SOCS3) inhibition of the STAT5b transcription factor signaling pathway.
IL-1 signaling modulates activation of STAT transcription factors to antagonize retinoic acid signaling and control the TH17 cell-iTreg cell balance.
Weaver et al., Birmingham, United States. In Nat Immunol, Mar 2015
By repressing expression of the negative regulator SOCS3 dependent on the transcription factor NF-κB, IL-1 increased the amplitude and duration of phosphorylation of the transcription factor STAT3 induced by TH17-polarizing cytokines, which led to an altered balance in the binding of STAT3 and STAT5 to shared consensus sequences in developing T cells.
The transcription factors Egr2 and Egr3 are essential for the control of inflammation and antigen-induced proliferation of B and T cells.
Wang et al., United Kingdom. In Immunity, 2012
We discovered that Egr2 and/or Egr3 directly induced expression of suppressor of cytokine signaling-1 (SOCS1) and SOCS3, inhibitors of STAT1 and STAT3, and also blocked the function of Batf, an AP-1 inhibitor, in B and T cells.
Mesenchymal stem/stromal cells induce the generation of novel IL-10-dependent regulatory dendritic cells by SOCS3 activation.
Zhao et al., Beijing, China. In J Immunol, 2012
IL-10-activated SOCS3 is fundamental for regulatory dendritic cell generation from embryonic fibroblast-mesenchymal stem/stromal cells to finally regulate immune response.
SOCS3 in immune regulation of inflammatory bowel disease and inflammatory bowel disease-related cancer.
van der Woude et al., Rotterdam, Netherlands. In Cytokine Growth Factor Rev, 2012
SOCS3 protein is an important regulator of cytokine signaling associated with inflammatory bowel disease and IBD-colorectal cancer[review]
A requirement for SOCS-1 and SOCS-3 phosphorylation in Bcr-Abl-induced tumorigenesis.
Chen et al., Beijing, China. In Neoplasia, 2012
Bcr-Abl may critically requires tyrosine phosphorylation of SOCS-1 and SOCS-3 to mediate tumorigenesis when these SOCS proteins are present in cells.
Angiotensin II induces angiogenic factors production partly via AT1/JAK2/STAT3/SOCS3 signaling pathway in MHCC97H cells.
Zhang et al., Xi'an, China. In Cell Physiol Biochem, 2011
present study demonstrates that Ang II induces angiogenic factors production partly via AT1/ JAK2/STAT3/SOCS3 signaling pathway in MHCC97H cells
Expression of SOCS1, SOCS2, and SOCS3 in growth hormone-stimulated skin fibroblasts from children with idiopathic short stature.
Fernando et al., Santiago, Chile. In J Pediatr Endocrinol Metab, 2011
High SOCS3 is associated with idiopathic short stature.
More papers using SOCS3 antibodies
A Role of Suppressor of Cytokine Signaling 3 (SOCS3/CIS3/SSI3) in CD28-mediated Interleukin 2 Production
Kubo Masato et al., In The Journal of Experimental Medicine, 1995
... The myc-tagged SOCS3 transgenic (Tg) mice under the ...
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