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Sorting nexin 2

SNX2, sorting nexin-2
This gene encodes a member of the sorting nexin family. Members of this family contain a phox (PX) domain, which is a phosphoinositide binding domain, and are involved in intracellular trafficking. This protein associates with formin-binding protein 17, but its function is unknown. This protein may form oligomeric complexes with family members. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: SNX1, VPS35, Vps29, Vps26, CAN
Papers on SNX2
Genome-Wide Association Study of Event-Free Survival in Diffuse Large B-Cell Lymphoma Treated With Immunochemotherapy.
Cerhan et al., Bordeaux, France. In J Clin Oncol, Dec 2015
RESULTS: In a meta-analysis of the four studies, the top loci for EFS were marked by rs7712513 at 5q23.2 (near SNX2 and SNCAIP; HR, 1.39; 95% CI, 1.23 to 1.57; P = 2.08 × 10(-7)), and rs7765004 at 6q21 (near MARCKS and HDAC2; HR, 1.38; 95% CI, 1.22 to 1.57; P = 7.09 × 10(-7)), although they did not reach conventional genome-wide significance (P = 5 × 10(-8)).
Identification of the receptor tyrosine kinases (RTKs)-oriented functional targets of miR-206 by an antibody-based protein array.
Han et al., China. In Febs Lett, Aug 2015
Within this network, we analyzed two validated targets, PAX3 and SNX2, and one candidate target, EIF4E, may account for the inhibitory effect of miR-206 on MET phosphorylation.
Subcellular localisation of retromer in post-endocytic pathways of polarised Madin-Darby canine kidney cells.
Verges et al., Valencia, Spain. In Biol Cell, 2014
Although subunits of the cargo-selective complex were enriched in early endosomes (EEs), levels of SNX2 were greater in sorting endosomes.
Biogenesis of lysosome-related organelles complex-1 subunit 1 (BLOS1) interacts with sorting nexin 2 and the endosomal sorting complex required for transport-I (ESCRT-I) component TSG101 to mediate the sorting of epidermal growth factor receptor into endosomal compartments.
Li et al., Beijing, China. In J Biol Chem, 2014
BLOS1 interacted with SNX2 (a retromer subunit) and TSG101 (an endosomal sorting complex required for transport subunit-I) to mediate EGFR lysosomal trafficking.
Rapid mapping of interactions between Human SNX-BAR proteins measured in vitro by AlphaScreen and single-molecule spectroscopy.
Gambin et al., Australia. In Mol Cell Proteomics, 2014
We find that while nine SNX-BAR proteins are able to form homo-dimers, several including the retromer-associated SNX1, SNX2, and SNX5 require heteromeric interactions for dimerization.
Loss of PiT-1 results in abnormal endocytosis in the yolk sac visceral endoderm.
Giachelli et al., Seattle, United States. In Mech Dev, 2014
The endocytosis genes Tfeb, Lamtor2 and Snx2 are increased at the RNA level.
Sorting Nexin 2 (SNX2): a potential marker of active thyrocytes in normal and hyperfunctioning thyroid disorders.
Itoh et al., Kōbe, Japan. In Appl Immunohistochem Mol Morphol, 2014
In this study, we demonstrated that SNX2 is expressed in columnar and active thyroid follicular cells but not in flattened inactive thyrocytes.
Sensitivity of SNX2-ABL1 toward tyrosine kinase inhibitors distinct from that of BCR-ABL1.
Kiyokawa et al., Tokyo, Japan. In Leuk Res, 2014
We introduced SNX2-ABL1, a novel ABL1-related chimeric transcript lacks SH3 and SH2 domains, into murine Ba/F3 cells and compared their function with that of BCR-ABL1.
Poor responses to tyrosine kinase inhibitors in a child with precursor B-cell acute lymphoblastic leukemia with SNX2-ABL1 chimeric transcript.
Mori et al., Japan. In Eur J Haematol, 2014
We have identified the fusion gene SNX2-ABL1 in a pediatric case of acute lymphoblastic leukemia (ALL), which has only once previously been reported in an adult patient.
Sorting nexin 2-mediated membrane trafficking of c-Met contributes to sensitivity of molecular-targeted drugs.
Ono et al., Fukuoka, Japan. In Cancer Sci, 2013
SNX1 and SNX2 are components of the mammalian retromer complex and they also play critical roles in the membrane trafficking of growth factor receptors including epidermal growth factor receptor (EGFR) and c-Met.
A SNX3-dependent retromer pathway mediates retrograde transport of the Wnt sorting receptor Wntless and is required for Wnt secretion.
Korswagen et al., Utrecht, Netherlands. In Nat Cell Biol, 2011
Here, we report that Wls recycling is mediated through a retromer pathway that is independent of the retromer sorting nexins SNX1-SNX2 and SNX5-SNX6.
Identification of FOXP1 and SNX2 as novel ABL1 fusion partners in acute lymphoblastic leukaemia.
Grand et al., Southampton, United Kingdom. In Br J Haematol, 2011
Molecular analysis revealed a FOXP1-ABL1 fusion for the t(3;9) and a SNX2-ABL1 fusion for the t(5;9).
A novel, retromer-independent role for sorting nexins 1 and 2 in RhoG-dependent membrane remodeling.
Ngsee et al., Ottawa, Canada. In Traffic, 2010
SNX1 and SNX2 interact with the Rac1 and RhoG guanine nucleotide exchange factor Kalirin-7. Overexpression of SNX1 or SNX2 and Kalirin-7 partially redistributes both SNXs to the plasma membrane, and results in RhoG-dependent lamellipodia formation.
Hurley et al., Bethesda, United States. In Curr Opin Cell Biol, 2008
The mammalian retromer complex comprises a sorting nexin dimer composed of a still undefined combination of SNX1, SNX2, SNX5 and SNX6, and a cargo-recognition trimer composed of Vps26, Vps29 and Vps35.
Retromer: multipurpose sorting and specialization in polarized transport.
Vergés, Valencia, Spain. In Int Rev Cell Mol Biol, 2007
A dimer of two sorting nexins-typically, SNX1 and/or SNX2-deforms the membrane and thus cooperates with retromer to ensure cargo sorting.
Functional architecture of the retromer cargo-recognition complex.
Hurley et al., Bethesda, United States. In Nature, 2007
Human retromer consists of two smaller complexes: the cargo recognition VPS26-VPS29-VPS35 heterotrimer and a membrane-targeting heterodimer or homodimer of SNX1 and/or SNX2 (ref.
Phosphoinositide-regulated retrograde transport of ricin: crosstalk between hVps34 and sorting nexins.
Sandvig et al., Oslo, Norway. In Traffic, 2007
study indicates that hVps34 and its product PI(3)P are involved in endosome to Golgi transport of ricin, and that SNX2 and SNX4 are likely to be effectors in this pathway
Interchangeable but essential functions of SNX1 and SNX2 in the association of retromer with endosomes and the trafficking of mannose 6-phosphate receptors.
Bonifacino et al., Bethesda, United States. In Mol Cell Biol, 2007
These observations indicate that the mammalian retromer complex assembles by sequential association of SNX1/2 and Vps26-Vps29-Vps35 subcomplexes on endosomal membranes and that SNX1 and SNX2 play interchangeable but essential roles.
Genetic evidence for a mammalian retromer complex containing sorting nexins 1 and 2.
Magnuson et al., Chapel Hill, United States. In Proc Natl Acad Sci U S A, 2005
Data describe a functional interaction between Hbeta58, sorting nexin 1 (SNX1), and SNX2 and strongly suggest that SNX2 plays a more critical role than SNX1 in retromer activity during embryonic development.
Sorting nexin-2 is associated with tubular elements of the early endosome, but is not essential for retromer-mediated endosome-to-TGN transport.
Cullen et al., Bristol, United Kingdom. In J Cell Sci, 2005
Data suggest that sorting nexin-2 is not essential for the regulation of endosome-to-trans Golgi network retrieval of the cation-independent mannose 6-phosphate receptor.
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