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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Dec 2016.

Sorting nexin 19

SNX19, sorting nexin 19
Top mentioned proteins: Insulin, OUT, IA-2, HAD, STEP
Papers on SNX19
Genome-wide associations between genetic and epigenetic variation influence mRNA expression and insulin secretion in human pancreatic islets.
Ling et al., Malmö, Sweden. In Plos Genet, 2014
Functional analyses further demonstrated that identified candidate genes (GPX7, GSTT1 and SNX19) directly affect key biological processes such as proliferation and apoptosis in pancreatic β-cells.
Structural basis for different phosphoinositide specificities of the PX domains of sorting nexins regulating G-protein signaling.
Collins et al., Australia. In J Biol Chem, 2014
The one exception to this is mammalian SNX19, which lacks the typical RGS structure but preserves all other domains.
Sorting nexin 19 regulates the number of dense core vesicles in pancreatic β-cells.
Inagaki et al., Kyoto, Japan. In J Diabetes Investig, 2012
We examined the effect of sorting nexin 19 (SNX19), an IA-2 interacting protein, on insulin secretion and the number of dense core vesicles (DCV).
Diagnosis and fine mapping of a deletion in distal 11q in two Chinese patients with developmental delay.
Jiang et al., Beijing, China. In J Hum Genet, 2010
Candidate genes for DD/MR in this region include SNX19, THYN1, OPCML, NCAPD3 and NTM.
Screening of chondrogenic factors with a real-time fluorescence-monitoring cell line ATDC5-C2ER: identification of sorting nexin 19 as a novel factor.
Kawaguchi et al., Tokyo, Japan. In Arthritis Rheum, 2009
Screening using the ATDC5-C2ER system identified several chondrogenic factors, including sorting nexin 19 (SNX19).
Overexpression of the autoantigen IA-2 puts beta cells into a pre-apoptotic state: autoantigen-induced, but non-autoimmune-mediated, tissue destruction.
Notkins et al., Bethesda, United States. In Clin Exp Immunol, 2007
A search for IA-2 interacting proteins revealed that IA-2 interacts with sorting nexin (SNX)19 and that SNX19, but not IA-2, inhibits the conversion of PtdIns(4,5)P2 to PtdIns(3,4,5)P3 and thereby suppresses the phosphorylation of proteins in the Akt signalling pathway resulting in apoptosis.
Five common gene variants identify elevated genetic risk for coronary heart disease.
Boerwinkle et al., Alameda, United States. In Genet Med, 2007
METHODS: We considered five variants that were associated with coronary heart disease in two studies and confirmed in the Atherosclerosis Risk in Communities study: rs20455 (KIF6), rs3900940 (MYH15), rs7439293 (PALLD), rs2298566 (SNX19), and rs1010 (VAMP8).
Amplified, lost, and fused genes in 11q23-25 amplicon in acute myeloid leukemia, an array-CGH study.
Knuutila et al., Helsinki, Finland. In Genes Chromosomes Cancer, 2006
Expression microarray of case 1 revealed that three of these genes, FLI1, NFRKB, and SNX19, were also overexpressed.
The IA-2 interactome.
Notkins et al., Bethesda, United States. In Diabetologia, 2005
RESULTS: Six new interacting proteins were identified by this approach: mitogen-activated protein kinase-activating death domain (MADD), the MADD isoform IG20, PTPrho, PTPsigma, sorting nexin 19 (SNX19) and cyclophilin A. Using a series of IA-2 deletion mutants, we identified the regions on the IA-2 molecule to which five of the interacting proteins bound.
Two-step differential expression analysis reveals a new set of genes involved in thyroid oncocytic tumors.
Reynier et al., Angers, France. In J Clin Endocrinol Metab, 2005
Seven of the 18 nuclear-encoded genes are involved in protein metabolism: DKFZP434I116, B3GTL, SNX19, RP42, SENP1, UBE2D3, and the CTSB gene, which is known to be particularly deregulated in most thyroid tumors.
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