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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Dec 2016.

Sorting nexin 17

SNX17, sorting nexin 17, KIAA0064
This gene encodes a member of the sorting nexin family. Members of this family contain a phox (PX) domain, which is a phosphoinositide binding domain, and are involved in intracellular trafficking. This protein does not contain a coiled coil region, like some family members, but contains a B41 domain. This protein interacts with the cytoplasmic domain of P-selectin, and may function in the intracellular trafficking of P-selectin. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: V1a, P-selectin, CAN, Ezrin, ACID
Papers on SNX17
A Novel PDZ Domain Interaction Mediates the Binding between Human Papillomavirus 16 L2 and Sorting Nexin 27 and Modulates Virion Trafficking.
Banks et al., Poznań, Poland. In J Virol, Oct 2015
UNLABELLED: Previous studies have demonstrated an interaction between sorting nexin 17 and the L2 capsid proteins from a variety of papillomavirus types.
SNX17 affects T cell activation by regulating TCR and integrin recycling.
Billadeau et al., Rochester, United States. In J Immunol, Jun 2015
One protein potentially involved in TCR transport is sorting nexin 17 (SNX17).
The recognition of membrane-bound PtdIns3P by PX domains.
Mark et al., Brisbane, Australia. In Proteins, 2014
In this work, molecular dynamic simulations have been used to explore the structure and dynamics of the p40(phox) -PX domain and the SNX17-PX domain and their interaction with membrane-bound PtdIns3P.
Sorting nexin 31 binds multiple β integrin cytoplasmic domains and regulates β1 integrin surface levels and stability.
Böttcher et al., Martinsried, Germany. In J Mol Biol, 2014
Trafficking of α5β1 integrin to lysosomes and its subsequent degradation is influenced by ligand occupancy and the binding of SNX17 via its protein 4.1, ezrin, radixin, moesin (FERM) domain to the membrane-distal NPxY motif in the cytoplasmic domain of β1 integrin in early endosomes.
Structural determinants for binding of sorting nexin 17 (SNX17) to the cytoplasmic adaptor protein Krev interaction trapped 1 (KRIT1).
Boggon et al., New Haven, United States. In J Biol Chem, 2014
Sorting nexin 17 (SNX17) is a member of the family of cytoplasmic sorting nexin adaptor proteins that regulate endosomal trafficking of cell surface proteins.
Sorting nexin 17 regulates ApoER2 recycling and reelin signaling.
Marzolo et al., Santiago, Chile. In Plos One, 2013
A previous yeast two-hybrid screen showed that ApoER2 is a binding partner of sorting nexin 17 (SNX17) - a cytosolic adaptor protein that regulates the trafficking of several membrane proteins in the endosomal pathway, including LRP1, P-selectin and integrins.
A sorting nexin 17-binding domain within the LRP1 cytoplasmic tail mediates receptor recycling through the basolateral sorting endosome.
Marzolo et al., Santiago, Chile. In Traffic, 2013
Sorting nexin 17 (SNX17) is an adaptor protein present in early endosomal antigen 1 (EEA1)-positive sorting endosomes that promotes the efficient recycling of low-density lipoprotein receptor-related protein 1 (LRP1) to the plasma membrane through recognition of the first NPxY motif in the cytoplasmic tail of this receptor.
Structural basis for endosomal trafficking of diverse transmembrane cargos by PX-FERM proteins.
Collins et al., Australia. In Proc Natl Acad Sci U S A, 2013
Here we present the crystal structure of the SNX17 FERM domain bound to the sorting motif of the P-selectin adhesion protein, revealing both the architecture of the atypical FERM domain and the molecular basis for recognition of these essential sorting sequences.
SNX17 facilitates infection with diverse papillomavirus types.
Banks et al., Trieste, Italy. In J Virol, 2013
Previous studies have shown that the human papillomavirus type 16 (HPV-16) L2 capsid protein plays an essential role in viral infection, in part through its interaction with sorting nexin 17 (SNX17).
Cell adhesion: a FERM grasp of the tail sorts out integrins.
Calderwood et al., New Haven, United States. In Curr Biol, 2012
As well as modulating integrin activation, a conserved NPxY motif in integrin cytoplasmic tails that binds the FERM-domain-containing proteins kindlin and sorting nexin 17 plays pivotal roles in integrin recycling and degradation.
Sorting nexin 17 prevents lysosomal degradation of β1 integrins by binding to the β1-integrin tail.
Fässler et al., Martinsried, Germany. In Nat Cell Biol, 2012
results identify SNX17 as a beta1-integrin-tail-binding protein that interacts with the free Kindlin-binding site in endosomes to stabilize beta1 integrins, resulting in their recycling to the cell surface where they can be reused
SNX17 protects integrins from degradation by sorting between lysosomal and recycling pathways.
Cullen et al., Bristol, United Kingdom. In J Cell Biol, 2012
depletion of SNX17 in HeLa cells resulted in lysosomal degradation of multiple members of the integrin family of extracellular matrix recep-tors.
SNX17 regulates Notch pathway and pancreas development through the retromer-dependent recycling of Jag1.
Pei et al., Guangzhou, China. In Cell Regen (lond), 2011
RESULTS: Here we identified SNX17 as a novel regulator of the Notch pathway.
PX-FERM proteins: A link between endosomal trafficking and signaling?
Collins et al., Australia. In Small Gtpases, 2011
We recently showed that several proteins that regulate endosomal recycling, SNX17, SNX27 and SNX31 are structurally and functionally related.2
Multifunctional receptor stabilin-1 in homeostasis and disease.
Kzhyshkowska, Mannheim, Germany. In Scientificworldjournal, 2009
Degradation of stabilin-1 seems to depend on the interaction with sorting nexin 17.
Adaptor protein sorting nexin 17 regulates amyloid precursor protein trafficking and processing in the early endosomes.
Bu et al., Saint Louis, United States. In J Biol Chem, 2008
SNX17 regulates amyloid precursor protein trafficking and processing in the early endosomes
Sorting nexin 17, a non-self-assembling and a PtdIns(3)P high class affinity protein, interacts with the cerebral cavernous malformation related protein KRIT1.
Bohnensack et al., Magdeburg, Germany. In Biochem Biophys Res Commun, 2006
SNX17 has a role in the indicated KRIT1 function in cell adhesion processes by integrin signaling
Sorting nexin 17 facilitates LRP recycling in the early endosome.
Bu et al., Saint Louis, United States. In Embo J, 2005
Snx 17 binds to a motif in the low-density lipoprotein (LDL) receptor-related protein (LRP) tail distinct from the endocytosis signals and promotes LRP sorting to the recycling pathway in the early endosomes.
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