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Sorting nexin 12

This gene encodes a member of the sorting nexin family. Members of this family contain a phox (PX) domain, which is a phosphoinositide binding domain, and are involved in intracellular trafficking. This protein does not contain a coiled coil region, like some family members. A similar protein in mouse may be involved in regulating the neurite outgrowth. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Jan 2012] (from NCBI)
Top mentioned proteins: SNX4, APP, SNX1, Autoantigen, SNX5
Papers on SNX12
Expression of sorting nexin 12 is regulated in developing cerebral cortical neurons.
Tanoue et al., Tokyo, Japan. In J Neurosci Res, 2012
Sorting nexin 12 (SNX12) is one of the SNXs family members; however, its function remains unknown.
SNX12 role in endosome membrane transport.
Gruenberg et al., Genève, Switzerland. In Plos One, 2011
In this paper, we investigated the role of sorting nexin 12 (SNX12) in the endocytic pathway.
Sorting nexin 12 interacts with BACE1 and regulates BACE1-mediated APP processing.
Zhang et al., Xiamen, China. In Mol Neurodegener, 2011
In this study, we investigated whether BACE1 trafficking and BACE1-mediated APP processing/Aβ generation are affected by sorting nexin 12 (SNX12), a member of the sorting nexin (SNX) family that is involved in protein trafficking regulation.
The role of metallothionein in the pathogenesis of acute lung injury.
Leikauf et al., Cincinnati, United States. In Am J Respir Cell Mol Biol, 2006
Metallothionein deficient mice have a marked decrease in Snx12 during acute lung injury
A large family of endosome-localized proteins related to sorting nexin 1.
Gleeson et al., San Diego, United States. In Biochem J, 2001
Searches of human expressed sequence tag databases with SNX1 revealed eleven related human cDNA sequences, termed SNX2 to SNX12, eight of them novel.
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