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Smad nuclear interacting protein 1

SNIP1, Smad nuclear interacting protein 1
This gene encodes a protein that contains a coiled-coil motif and C-terminal forkhead-associated (FHA) domain. The encoded protein functions as a transcriptional coactivator that increases c-Myc activity and inhibits transforming growth factor beta (TGF-beta) and nuclear factor kappa-B (NF-kB) signaling. The encoded protein also regulates the stability of cyclin D1 mRNA, and may play a role in cell proliferation and cancer progression. Mutations in this gene are a cause of psychomotor retardation, epilepsy, and craniofacial dysmorphism (PMRED). [provided by RefSeq, Mar 2012] (from NCBI)
Top mentioned proteins: p300, PCNA, CBP, HAD, c-Myc
Papers on SNIP1
Neuroimaging data sharing on the neuroinformatics database platform.
Pearlson et al., Hartford, United States. In Neuroimage, Feb 2016
Data from the multi-site projects Autism Brain Imaging Data Exchange (ABIDE), Bipolar-Schizophrenia Network on Intermediate Phenotypes parts one and two (B-SNIP1, B-SNIP2), and Monetary Incentive Delay task (MID) are available for download from the public instance of NiDB, with more projects sharing data as it becomes available.
miR-301a promotes intestinal mucosal inflammation through induction of IL-17A and TNF-α in IBD.
Liu et al., Shanghai, China. In Gut, Oct 2015
SNIP1 as a functional target of miR-301a was reduced in miR-301a expression but increased in LV-anti-miR-301a expression.
Smad nuclear interacting protein, SNIP1, mediates the ecdysteroid signal transduction in red crayfish Procambarus clarkii.
Zhu et al., Hefei, China. In J Exp Zool A Ecol Genet Physiol, Feb 2015
A smad nuclear interacting protein 1 (SNIP1) homolog was identified in the crayfish Procambarus clarkii and this gene encoded a polypeptide of 288 amino acids.
Effects of ornithine decarboxylase antizyme 1 on the proliferation and differentiation of human oral cancer cells.
Jiang et al., Guangzhou, China. In Int J Mol Med, 2014
To elucidate the possible mechanism of LOR upregulation by OAZ1, further experiments were performed and it was found that the OAZ1 expression inhibited Smad nuclear interacting protein 1 (SNIP1) at the protein level and RNA interference of SNIP1 in SCC15 cells, which increased the expression of LOR.
lncRNA directs cooperative epigenetic regulation downstream of chemokine signals.
Yang et al., Houston, United States. In Cell, 2014
BCAR4 binding of SNIP1 and PNUTS in response to CCL21 releases the SNIP1's inhibition of p300-dependent histone acetylation, which in turn enables the BCAR4-recruited PNUTS to bind H3K18ac and relieve inhibition of RNA Pol II via activation of the PP1 phosphatase.
Sniff nasal inspiratory pressure does not decrease in elderly subjects.
Chen et al., Taiwan. In J Phys Ther Sci, 2014
The highest values among the first 10 and last 10 SNIP maneuvers were recorded as SNIP1-10, and SNIP11-20, respectively.
Identification of new mechanisms of cellular response to chemotherapy by tracking changes in post-translational modifications by ubiquitin and ubiquitin-like proteins.
Soubeyran et al., Marseille, France. In J Proteome Res, 2014
Importantly, we could validate the gemcitabine-induced PTMs variations of relevant candidates and we could demonstrate the biological significance of such altered PTMs by studying in detail the sumoylation of SNIP1, one of these new targets.
High expression of SNIP1 correlates with poor prognosis in non-small cell lung cancer and SNIP1 interferes with the recruitment of HDAC1 to RB in vitro.
Jen et al., Taegu, South Korea. In Lung Cancer, 2013
In this study, we demonstrate that SNIP1, RB and HDAC1 were significantly expressed in same lung cancer tissues in a tissue microarray (TMA) containing 300 non-small cell lung cancers (NSCLC).
Silencing of the Smad nuclear interacting protein 1 (SNIP1) by siRNA inhibits proliferation and induces apoptosis in pituitary adenoma cells.
Luo et al., Shanghai, China. In Tumour Biol, 2013
Smad nuclear interacting protein 1 (SNIP1) gene encodes a protein that contains a conservative C-terminal forkhead-associated domain and functions as a transcriptional coactivator to regulate cell proliferation and cancer progression.
TWIST1 promoter methylation is associated with prognosis in tonsillar squamous cell carcinoma.
Cho et al., Anyang, South Korea. In Hum Pathol, 2013
Immunohistochemical analyses of TWIST1, Snail, and SMAD nuclear interacting protein-1 (SNIP1) were performed in 65 formalin-fixed, paraffin-embedded blocks of surgically resected specimens.
Expression, covariation, and genetic regulation of miRNA Biogenesis genes in brain supports their role in addiction, psychiatric disorders, and disease.
Hamre et al., Memphis, United States. In Front Genet, 2012
However, in mouse striatum, many members of the miRNA pathway are correlated-including Dicer, Drosha, Pasha, Ars2 (Srrt), Eif2c1 (Ago1), Eif2c2 (Ago2), Zcchc11, and Snip1.
SNIP1: a new activator of HSE signaling pathway.
Yu et al., Shanghai, China. In Mol Cell Biochem, 2012
SNIP1 in cells strongly activated the heat shock element signaling pathway, and SNIP1 might selectively regulate the transcription of some heat shock proteins through associating with heat shock elements
Genetic mapping and exome sequencing identify variants associated with five novel diseases.
Strauss et al., United States. In Plos One, 2011
Study identified sequence variants in the known disease-causing genes SLC6A3 and FLVCR1, and present evidence to strongly support the pathogenicity of variants identified in TUBGCP6, BRAT1, SNIP1, CRADD, and HARS.
Hypoxia-inducible factor-1 alpha, in association with TWIST2 and SNIP1, is a critical prognostic factor in patients with tongue squamous cell carcinoma.
Tang et al., Chengdu, China. In Oral Oncol, 2011
overexpression of HIF-1alpha, TWIST2 or SNIP1 correlated with poor disease-free survival in patients with tongue squamous cell carcinoma
Regulation of cyclin D1 gene expression.
Perkins et al., Bristol, United Kingdom. In Biochem Soc Trans, 2010
Here, we discuss the ability of the NF-kappaB (nuclear factor kappaB)/IKK [IkappaB (inhibitor of NF-kappaB) kinase] pathways to regulate cyclin D1 gene transcription and also consider the newly discovered role of the SNARP (SNIP1/SkIP-associated RNA processing) complex as a co-transcriptional regulator of cyclin D1 RNA stability.
Regulation of cyclin D1 RNA stability by SNIP1.
Perkins et al., Dundee, United Kingdom. In Cancer Res, 2008
Study shows a novel mechanism regulating Cyclin D1 expression and offers new insight into the role of SNIP1 and associated proteins as regulators of proliferation and cancer.
The FHA domain proteins DAWDLE in Arabidopsis and SNIP1 in humans act in small RNA biogenesis.
Chen et al., Riverside, United States. In Proc Natl Acad Sci U S A, 2008
SNIP1, the human homolog of DDL, is involved in miRNA biogenesis and interacts with Drosha
The 26S proteasome system in the signaling pathways of TGF-beta superfamily.
Wang, Seattle, United States. In Front Biosci, 2003
Through the interaction with proteasome beta subunit HsN3 and the substrate marker protein ornithine decarboxylase antizyme (AZ), the BMP responsive Smad1 regulates the proteasomal targeting events that contribute to the degradation of Smad1 and its interacting proteins, one of which is SNIP1, a repressor of the transcriptional co-activator CBP/p300.
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