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Single-strand-selective monofunctional uracil-DNA glycosylase 1

SMUG1, single-strand-selective monofunctional uracil-DNA glycosylase
This gene encodes a protein that participates in base excision repair by removing uracil from single- and double-stranded DNA. Many alternatively spliced transcript variants exist for this gene; the full-length nature is known for some but not all of the variants. [provided by RefSeq, Aug 2011] (from NCBI)
Top mentioned proteins: uracil-DNA glycosylase, CAN, TDG, XRCC1, hBD-4
Papers on SMUG1
DNA repair prognostic index modelling reveals an essential role for base excision repair in influencing clinical outcomes in ER negative and triple negative breast cancers.
Madhusudan et al., Nottingham, United Kingdom. In Oncotarget, Oct 2015
In the current study, a cohort of 880 ER- (including 635 TNBCs) was immuno-profiled for a panel of DNA repair proteins including: Pol β, FEN1, APE1, XRCC1, SMUG1, PARP1, BRCA1, ATR, ATM, DNA-PKcs, Chk1, Chk2, p53, and TOPO2.
AID expression in B-cell lymphomas causes accumulation of genomic uracil and a distinct AID mutational signature.
Krokan et al., Trondheim, Norway. In Dna Repair (amst), 2015
Moreover, we observed an inverse correlation of genomic uracil with uracil excision activity and expression of the uracil-DNA glycosylases UNG and SMUG1.
Is there a role for base excision repair in estrogen/estrogen receptor-driven breast cancers?
Madhusudan et al., Nottingham, United Kingdom. In Antioxid Redox Signal, 2015
To test this hypothesis, we investigated 1406 ER(+) early-stage breast cancers with 20 years' long-term clinical follow-up data for DNA polymerase β (pol β), flap endonuclease 1 (FEN1), AP endonuclease 1 (APE1), X-ray cross-complementation group 1 protein (XRCC1), single-strand monofunctional uracil glycosylase-1 (SMUG1), poly (ADP-ribose) polymerase 1 (PARP1), ataxia telangiectasia mutated and Rad3 related (ATR), ataxia telangiectasia mutated (ATM), DNA-dependent protein kinase catalytic subunit (DNA-PKcs), Chk1, Chk2, p53, breast cancer susceptibility gene 1 (BRCA1), and topoisomerase 2 (TOPO2) expression.
Human DNA glycosylase enzyme TDG repairs thymine mispaired with exocyclic etheno-DNA adducts.
Sugimura et al., Tokyo, Japan. In Free Radic Biol Med, 2014
To test this hypothesis, we examined the activities of the DNA glycosylase proteins OGG1, SMUG1, TDG, NEIL1, MUTYH, NTH1, MPG, and UNG2 against double-stranded oligonucleotides containing 1,N(6)-ethenoadenine (εA), 3,N(4)-ethenocytosine (εC), butanone-ethenocytosine (BεC), butanone-ethenoguanine (BεG), heptanone-ethenocytosine (HεC), or heptanone-ethenoguanine (HεG) using a DNA cleavage assay.
Clinicopathological significance of ATM-Chk2 expression in sporadic breast cancers: a comprehensive analysis in large cohorts.
Madhusudan et al., Nottingham, United Kingdom. In Neoplasia, 2014
Breast cancer 1, early onset negative, low XRCC1, low SMUG1, high FEN1, high MIB1, p53 mutants, low MDM2, low Bcl-2, low p21, low Bax, high CDK1, and low Chk2 were also more frequent in tumors with low nuclear ATM level (Ps < .05).
Excision of uracil from transcribed DNA negatively affects gene expression.
Khobta et al., Mainz, Germany. In J Biol Chem, 2014
In the case of U:A pairs, this effect was retarded significantly by knockdown of UNG1/2 but not by knockdown of SMUG1 or thymine-DNA glycosylase uracil-DNA glycosylases, proving that it is base excision by UNG1/2 that perturbs transcription of the affected gene.
Refining the Neuberger model: Uracil processing by activated B cells.
Gearhart et al., Baltimore, United States. In Eur J Immunol, 2014
44: 1925-1935] examine uracil processing in B cells in the absence of UNG and SMUG1 glycosylases.
Uracil excision by endogenous SMUG1 glycosylase promotes efficient Ig class switching and impacts on A:T substitutions during somatic mutation.
Rada et al., Cambridge, United Kingdom. In Eur J Immunol, 2014
We now show that most of the residual class switching in Ung(-/-) mice depends upon the endogenous SMUG1 uracil-DNA glycosylase, with in vitro switching to IgG1 as well as serum IgG3, IgG2b, and IgA greatly diminished in Ung(-/-) Smug1(-/-) mice, and that Smug1 partially compensates for Ung deficiency over time.
Regulatory mechanisms of RNA function: emerging roles of DNA repair enzymes.
Nilsen et al., Norway. In Cell Mol Life Sci, 2014
We also discuss the roles of two base excision repair enzymes, SMUG1 and APE1, in RNA quality control.
Error-free versus mutagenic processing of genomic uracil--relevance to cancer.
Slupphaug et al., Trondheim, Norway. In Dna Repair (amst), 2014
Thus, the alternative uracil-removing glycosylases, SMUG1, TDG and MBD4 cannot efficiently complement UNG2-deficiency.
Adverse prognostic and predictive significance of low DNA-dependent protein kinase catalytic subunit (DNA-PKcs) expression in early-stage breast cancers.
Madhusudan et al., Nottingham, United Kingdom. In Breast Cancer Res Treat, 2014
The absence of BRCA1, low XRCC1, low SMUG1, low APE1 and low Polβ was also more likely in low DNA-PKcs expressing tumours (ps < 0.05).
Germline ablation of SMUG1 DNA glycosylase causes loss of 5-hydroxymethyluracil- and UNG-backup uracil-excision activities and increases cancer predisposition of Ung-/-Msh2-/- mice.
Neuberger et al., Cambridge, United Kingdom. In Nucleic Acids Res, 2012
SMUG1 is the dominant glycosylase responsible for 5-hydroxymethyluracil-excision in mice as well as the major UNG-backup for U-excision.
Strikingly different properties of uracil-DNA glycosylases UNG2 and SMUG1 may explain divergent roles in processing of genomic uracil.
Kavli et al., Trondheim, Norway. In Dna Repair (amst), 2012
Data show that uracil-DNA glycosylases SMUG1 and UNG2 display widely different sequence preferences.
Genetic variability in DNA repair proteins in age-related macular degeneration.
Kaarniranta et al., Łódź, Poland. In Int J Mol Sci, 2011
We observed that the g.4235T>C (rs2337395) and c.-32A>G (rs3087404) polymorphisms in two genes encoding such glycosylases, UNG and SMUG1, respectively, could be associated with the occurrence of AMD.
Single nucleotide polymorphisms in uracil-processing genes, intake of one-carbon nutrients and breast cancer risk.
Shields et al., Washington, D.C., United States. In Eur J Clin Nutr, 2011
there was increased risk of breast cancer among postmenopausal women heterozygous for either SMUG1 rs2029166 or rs7296239. Among premenopausal women, the increased risk associated with SMUG1 rs2029166 was limited to those with low folate intake.
Uracil-DNA glycosylase in base excision repair and adaptive immunity: species differences between man and mouse.
Kavli et al., Trondheim, Norway. In J Biol Chem, 2011
analysis of species specific differences between mouse and humans in regulation of SMUG1 and UNG2
Opposite-base dependent excision of 5-formyluracil from DNA by hSMUG1.
Bjelland et al., Stavanger, Norway. In Int J Radiat Biol, 2009
hSMUG1 excised fU from DNA opposite all normal bases with the highest activity when opposite non-cognate C or T followed by G and cognate A
Uracil in DNA and its processing by different DNA glycosylases.
Krokan et al., Trondheim, Norway. In Philos Trans R Soc Lond B Biol Sci, 2009
Five mammalian uracil-DNA glycosylases have been identified; these are mitochondrial UNG1 and nuclear UNG2, both encoded by the UNG gene, and the nuclear proteins SMUG1, TDG and MBD4.
[Uracil-DNA glycosylases].
Błasiak et al., Philadelphia, United States. In Postepy Biochem, 2007
Eukaryotes have at least four nuclear UDGs: UNG2, SMUG1, TDG i MBD4, while UNG1 operates in the mitochondrium.
Uracil-DNA glycosylase acts by substrate autocatalysis.
Karplus et al., Oxford, United Kingdom. In Nature, 2001
A corresponding catalytic mechanism could apply to the DNA glycosylases TDG and SMUG1, which belong to the same structural superfamily as UDG.
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