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Nuclear receptor corepressor 1

SMRT, N-CoR, Trac
This gene encodes a protein that mediates ligand-independent transcription repression of thyroid-hormone and retinoic-acid receptors by promoting chromatin condensation and preventing access of the transcription machinery. It is part of a complex which also includes histone deacetylases and transcriptional regulators similar to the yeast protein Sin3p. This gene is located between the Charcot-Marie-Tooth and Smith-Magenis syndrome critical regions on chromosome 17. Alternate splicing results in multiple transcript variants. Pseudogenes of this gene are found on chromosomes 17 and 20.[provided by RefSeq, Jun 2010] (from NCBI)
Top mentioned proteins: Histone, CAN, ACID, V1a, HDAC3
Papers using SMRT antibodies
Curcumin Sensitizes Acute Promyelocytic Leukemia Cells to Unfolded Protein Response-induced Apoptosis by Blocking the Loss of Misfolded N-CoR Protein.
Defossez Pierre-Antoine, In PLoS ONE, 2010
... The N-CoR [C-20] (goat polyclonal) antibody was purchased from Santa Cruz Biotechnology (California, USA) and used ...
Regulation of E2F1 activity by acetylation.
Vanacker Jean-Marc, In PLoS ONE, 1999
... Polyclonal anti-Sirt-1 and anti-NCoR were purchased from Abcam PLC (Cambridge, UK) ...
Requirement for RAR-mediated gene repression in skeletal progenitor differentiation
Underhill T. Michael et al., In The Journal of Cell Biology, 1994
... herein) consists of the DNA binding domain of GAL4 fused to the 3′ region of N-CoR encompassing amino acids 2,174–2,453 as described (Heinzel et al., 1997).Reporter vectors from Systems 1 and 2 of CLONTECH Laboratories Inc.'s Mercury Pathway ...
Papers on SMRT
Autoregulatory loop of nuclear corepressor 1 expression controls invasion, tumor growth, and metastasis.
Aranda et al., Madrid, Spain. In Proc Natl Acad Sci U S A, Feb 2016
Nuclear corepressor 1 (NCoR) associates with nuclear receptors and other transcription factors leading to transcriptional repression.
SIK1 silencing promotes HCC progression and WNT/β-catenin activation.
Zhang et al., Changchun, China. In J Hepatol, Feb 2016
Mechanistically, SIK1 phosphorylates SMRT at T1391, which promotes the association of NCoR/SMRT with TBL1/TBLR1 and disrupts the binding of β-catenin to TBL1/TBLR1 complex, thereby inactivating the Wnt/β-catenin pathway.
A specific mutation in TBL1XR1 causes Pierpont syndrome.
Hennekam et al., Amsterdam, Netherlands. In J Med Genet, Feb 2016
The mutant TBL1XR1 protein assembled correctly into the nuclear receptor corepressor (NCoR)/ silencing mediator for retinoid and thyroid receptors (SMRT) complex, suggesting a dominant-negative mechanism.
The programming effects of nutrition-induced catch-up growth on gut microbiota and metabolic diseases in adult mice.
Wang et al., Beijing, China. In Microbiologyopen, Feb 2016
Then, the offspring were randomly weaned to either NC or high fat (HF) diet until 32 weeks of age, generating four experimental groups: NC-NC, NC-HF, LP-NC, and LP-HF.
Deciphering the streamlined genome of Streptomyces xiamenensis 318 as the producer of the anti-fibrotic drug candidate xiamenmycin.
Xu et al., Shanghai, China. In Sci Rep, Dec 2015
The whole genome sequence of strain 318 was obtained through long-read single-molecule real-time (SMRT) sequencing, high-throughput Illumina HiSeq and 454 pyrosequencing technologies.
Dissecting the Rev-erbα Cistrome and the Mechanisms Controlling Circadian Transcription in Liver.
Lazar et al., Philadelphia, United States. In Cold Spring Harb Symp Quant Biol, Oct 2015
Oscillation of clock genes was enforced by direct competition between Rev-erbα and RORα for binding to cognate motifs in the genome, whereas metabolic CCGs were governed by recruitment of the NCoR/HDAC3 complex to enhancers where Rev-erbα is tethered by tissue-specific TFs.
Perspective on unraveling the versatility of 'co-repressor' complexes.
Vermeulen et al., Nijmegen, Netherlands. In Biochim Biophys Acta, Aug 2015
During the last decades, several so-called co-repressor protein complexes that carry out the reverse process, histone deacetylation, have been identified and characterized, such as the Sin3, N-CoR/SMRT and NuRD complexes.
The Xist lncRNA interacts directly with SHARP to silence transcription through HDAC3.
Guttman et al., Pasadena, United States. In Nature, Jun 2015
We show that SHARP, which interacts with the SMRT co-repressor that activates HDAC3, is not only essential for silencing, but is also required for the exclusion of RNA polymerase II (Pol II) from the inactive X.
TBL1XR1 in physiological and pathological states.
Zhang et al., North Bay Shore, United States. In Am J Clin Exp Urol, 2014
Transducin (beta)-like 1X related protein 1 (TBL1XR1/TBLR1) is an integral subunit of the NCoR (nuclear receptor corepressor) and SMRT (silencing mediator of retinoic acid and thyroid hormone receptors) repressor complexes.
The use of human pluripotent stem cells for the in vitro derivation of cranial placodes and neural crest cells.
Barberi et al., San Antonio, United States. In Curr Top Dev Biol, 2014
Here, we discuss the current state of the art in directing hPSCs into NC or CP cells, which in spite of their importance is still in its infancy.
Nuclear receptor corepressor complexes in cancer: mechanism, function and regulation.
Zhang et al., Saint Louis, United States. In Am J Clin Exp Urol, 2013
Nuclear receptor corepressor (NCoR) and silencing mediator for retinoid and thyroid hormone receptors (SMRT) function as corepressors for diverse transcription factors including nuclear receptors such as estrogen receptors and androgen receptors.
NCoR repression of LXRs restricts macrophage biosynthesis of insulin-sensitizing omega 3 fatty acids.
Olefsky et al., San Diego, United States. In Cell, 2013
The corepressor NCoR interacts with inflammatory pathway genes in macrophages, suggesting that its removal would result in increased activity of inflammatory responses.
Activity-dependent phosphorylation of MeCP2 threonine 308 regulates interaction with NCoR.
Greenberg et al., Boston, United States. In Nature, 2013
Here we show that the phosphorylation of T308 blocks the interaction of the repressor domain of MeCP2 with the nuclear receptor co-repressor (NCoR) complex and suppresses the ability of MeCP2 to repress transcription.
Rev-Erbs repress macrophage gene expression by inhibiting enhancer-directed transcription.
Glass et al., San Diego, United States. In Nature, 2013
Rev-Erbs function as transcriptional repressors by recruiting nuclear receptor co-repressor (NCoR)-HDAC3 complexes to Rev-Erb response elements in enhancers and promoters of target genes, but the molecular basis for cell-specific programs of repression is not known.
Metabolic stress modulates Alzheimer's β-secretase gene transcription via SIRT1-PPARγ-PGC-1 in neurons.
Liao et al., Memphis, United States. In Cell Metab, 2013
The interference on the BACE1 gene identified here represents a unique noncanonical mechanism of PPARγ-PGC-1 in transcriptional repression in neurons in response to metabolic signals that may involve recruitment of corepressor NCoR.
Altered corepressor SMRT expression and recruitment to target genes as a mechanism that change the response to androgens in prostate cancer progression.
Onate et al., Concepción, Chile. In Biochem Biophys Res Commun, 2012
altered recruitment and loss of corepressors SMRT/NCoR may provide a mechanism that changes the response of AR function to ligands and contributes to the progression of the advanced stages of human prostate cancer.
Estrogen receptor beta binds Sp1 and recruits a corepressor complex to the estrogen receptor alpha gene promoter.
Andò et al., Rende, Italy. In Breast Cancer Res Treat, 2012
A novel mechanism by which overexpression of estrogen receptor (ER) beta through NCoR is able to down regulate ER alpha gene expression, thus blocking ER alpha's driving role on breast cancer cell growth.
Integrative genomics identifies the corepressor SMRT as a gatekeeper of adipogenesis through the transcription factors C/EBPβ and KAISO.
Deplancke et al., Lausanne, Switzerland. In Mol Cell, 2012
SMRT is an adipogenic gatekeeper as it directly fine-tunes transcription of pro- and antiadipogenic genes.
The Bcl6-SMRT/NCoR cistrome represses inflammation to attenuate atherosclerosis.
Evans et al., Los Angeles, United States. In Cell Metab, 2012
These results reveal that Bcl6-SMRT/NCoR complexes constrain immune responses and contribute to the prevention of atherosclerosis.
Role of misfolded N-CoR mediated transcriptional deregulation of Flt3 in acute monocytic leukemia (AML)-M5 subtype.
Khan et al., Singapore, Singapore. In Plos One, 2011
Findings suggest that N-CoR-induced repression of Flt3 might be crucial for limiting the contribution of the Flt3 signaling pathway on the growth potential of leukemic cells.
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