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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Dec 2016.


smoothelin, SMTN
This gene encodes a structural protein that is found exclusively in contractile smooth muscle cells. It associates with stress fibers and constitutes part of the cytoskeleton. This gene is localized to chromosome 22q12.3, distal to the TUPLE1 locus and outside the DiGeorge syndrome deletion. Alternative splicing of this gene results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, May 2011] (from NCBI)
Top mentioned proteins: Actin, SM22alpha, CAN, MUC4, Desmin
Papers on smoothelin
Regional specific modulation of the glycocalyx and smooth muscle cell contractile apparatus in conduit arteries of tail-suspended rats.
Deng et al., Beijing, China. In J Appl Physiol, Jan 2016
The relative mRNA levels of syndecan-2, 3, 4, glypican-1, smooth muscle protein 22 (SM22), smoothelin (SMTN), and calponin were enhanced to 1.40, 1.53, 1.70, 1.90, 2.93, 2.30, and 5.23-fold respectively in the common carotid artery of the TS rat.
Increased IGF-IEc expression and mechano-growth factor production in intestinal muscle of fibrostenotic Crohn's disease and smooth muscle hypertrophy.
Kuemmerle et al., Richmond, United States. In Am J Physiol Gastrointest Liver Physiol, Jan 2016
Smooth muscle-specific protein expression of α-smooth muscle actin, γ-smooth muscle actin, and smoothelin was increased in affected intestine.
New Amniotic Membrane Based Biocomposite for Future Application in Reconstructive Urology.
Drewa et al., Bydgoszcz, Poland. In Plos One, Dec 2015
RESULTS: Immunohistohemical analysis (hematoxylin and eosin [H&E], anti-smoothelin and Masson's trichrome staining [TRI]) revealed effective regeneration of the urothelial and smooth muscle layers.
In situ analysis of smoothelin-like 1 and calmodulin interactions in smooth muscle cells by proximity ligation.
MacDonald et al., Calgary, Canada. In J Cell Biochem, Nov 2015
The smoothelin-like 1 (SMTNL1) protein is the newest member of the smoothelin family of muscle proteins.
Tubular Compressed Collagen Scaffolds for Ureteral Tissue Engineering in a Flow Bioreactor System.
Frey et al., Lausanne, Switzerland. In Tissue Eng Part A, Sep 2015
This was confirmed by their gene expression of smooth muscle alpha-actin, smoothelin, collagen type I and III, elastin, laminin type 1 and 5, cytokeratin 8, and uroplakin 2. In addition, smooth muscle cell alignment predominantly perpendicular to the flow direction was observed, comparable to the cell orientation in native ureteral tissue.
Pregnancy and Smoothelin-like Protein 1 (SMTNL1) Deletion Promote the Switching of Skeletal Muscle to a Glycolytic Phenotype in Human and Mice.
Haystead et al., Debrecen, Hungary. In J Biol Chem, Aug 2015
We conducted global microarray, proteomic, and metabolic analyses to study the role of the progesterone receptor and its transcriptional regulator, smoothelin-like protein 1 (SMTNL1) in the adaptation of skeletal muscle to pregnancy.
[Effect of platelet-derived growth factor-BB on rat corpus cavernosum smooth muscle cell proliferation, migration and phenotypic modulation].
Wei et al., Guangzhou, China. In Nan Fang Yi Ke Da Xue Xue Bao, Jul 2015
RESULT: In CCSM cell culture, 96.5%and 96% of the cells were positive for αSMA and smoothelin, respectively.
External vibration enhances macromolecular crowding for construction of aligned three-dimensional collagen fibril scaffolds.
Wu et al., Taiwan. In Biofabrication, Jun 2015
The aligned reconstituted collagen fibril matrix also enhanced the expression of smoothelin (a specific marker of contractile phenotype) of thoracic aortic smooth muscle cell (A7r5) relative to the randomly distributed collagen fibril matrix.
Mutation specific functions of EGFR result in a mutation-specific downstream pathway activation.
French et al., Rotterdam, Netherlands. In Eur J Cancer, May 2015
Differential binding was confirmed using a proximity ligation assay and/or Western Blot for the dedicator of cytokinesis 4 (DOCK4), UDP-glucose glycoprotein glucosyltransferase 1 (UGGT1), MYC binding protein 2 (MYCBP2) and Smoothelin (SMTN).
Antigenic profile of muscularis mucosae and muscularis propria of the urinary bladder.
Górnicka et al., Warsaw, Poland. In Iran J Immunol, Mar 2015
Antibodies against actin, caldesmon, type IV collagen, cytokeratin, desmin, elastin, fibronectin, filamin, laminin, miotilin, smoothelin, and vimentin were used.
Best practices recommendations in the application of immunohistochemistry in the bladder lesions: report from the International Society of Urologic Pathology consensus conference.
Members of the ISUP Immunohistochemistry in Diagnostic Urologic Pathology Group et al., Córdoba, Spain. In Am J Surg Pathol, 2014
Limited experience and conflicting data preclude smoothelin or vimentin to be recommended routinely for subclassifying muscle type at this time.
Novel contributions of the smoothelin-like 1 protein in vascular smooth muscle contraction and its potential involvement in myogenic tone.
MacDonald et al., Calgary, Canada. In Microcirculation, 2014
Of particular interest is the SMTN family of proteins, consisting of SMTN-A, SMTN-B, and the SMTN-like protein, SMTNL1.
Clinicopathological features of primary leiomyosarcoma of the gastrointestinal tract following recognition of gastrointestinal stromal tumours.
Oda et al., Fukuoka, Japan. In Histopathology, 2013
Immunohistochemically, the tumours were positive for α-smooth muscle actin (86%), muscle-specific actin (71%), desmin (86%), calponin (71%), h-caldesmon (57%) and smoothelin (71%).
Limited smoothelin expression within the muscularis mucosae: validation in bladder diverticula.
Amin et al., Cleveland, United States. In Hum Pathol, 2011
Smoothelin immunoreactivity in bladder diverticula confirms limited nature of smoothelin expression in muscularis mucosae and represents useful ancillary technique in proper histopathologic evaluation of diverticular and nondiverticular bladder carcinoma
Expression of smoothelin and smooth muscle actin in the skin.
Aneiros et al., Granada, Spain. In Histol Histopathol, 2011
We report the first study of smoothelin expression in normal skin
Immunohistochemical staining for smoothelin in the duplicated versus the true muscularis mucosae of Barrett esophagus.
Streutker et al., Toronto, Canada. In Am J Surg Pathol, 2011
Immunohistochemistry for smoothelin identifies differential staining between the neomuscularis mucosa and the true muscularis mucosa in Barrett's esophagus.
Clinical utility of immunohistochemistry in the diagnoses of urinary bladder neoplasia.
Cheng et al., Indianapolis, United States. In Appl Immunohistochem Mol Morphol, 2010
In this article, we review the clinical utility of immunohistochemistry in a series of diagnostic scenarios, including flat urothelial lesions with atypia, rare variants of urothelial carcinoma, primary adenocarcinoma versus secondary colorectal tumors, distinguishing prostate from urothelial carcinoma, and the utility of smoothelin in staging bladder carcinoma.
Smoothelin is a specific and robust marker for distinction of muscularis propria and muscularis mucosae in the gastrointestinal tract.
Kristiansen et al., Zürich, Switzerland. In Histopathology, 2010
The expression of smoothelin was analysed immunohistochemically in comparison with alpha-smooth muscle actin (alpha-SMA) in specimens from colon, stomach and oesophagus (n = 107).
Smoothelin immunohistochemistry is a useful adjunct for assessing muscularis propria invasion in bladder carcinoma.
Allan et al., Gainesville, United States. In Histopathology, 2010
Smoothelin immunohistochemistry has diagnostic utility in the evaluation of muscularis propria invasion in urothelial carcinoma.
Smoothelin in vascular smooth muscle cells.
Rensen et al., Maastricht, Netherlands. In Trends Cardiovasc Med, 2007
Smoothelin-A and -B have only been found in fully differentiated contractile smooth muscle cells.
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