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Solute carrier family 5

SMIT, SLC5A3, sodium/myo-inositol cotransporter
participate in osmoregulation in cells and tissues [RGD, Feb 2006] (from NCBI)
Top mentioned proteins: ACID, TonEBP, CAN, V1a, Rdl
Papers using SMIT antibodies
Systematic and integrative analysis of large gene lists using DAVID bioinformatics resources
Caselle Michele et al., In BMC Genomics, 2008
... The first line of the figure is MIR core sequence (Smit et al., 1995); the binding site of half-ERE is in ...
Papers on SMIT
Deficiency in the α1 subunit of Na+/K+-ATPase enhances the anti-proliferative effect of high osmolality in nucleus pulposus intervertebral disc cells.
Kletsas et al., Athens, Greece. In J Cell Physiol, Dec 2015
A 5- and a 24-h hyperosmotic treatment led to the differential expression of >100 and >200 genes, respectively, including nine genes encoding transporters (SLC4A11, SLC5A3, ATP1A1, SLC38A2, KCNK17, KCTD20, KCTD11, SLC7A5, and CLCA2).
NFAT5 Is Up-Regulated by Hypoxia: Possible Implications in Preeclampsia and Intrauterine Growth Restriction.
Illanes et al., Santiago, Chile. In Biol Reprod, Jul 2015
NFAT5 downstream targets aldose reductase (AR) and sodium-myo-inositol cotransporter (SMIT; official symbol SLC5A3) were not significantly up-regulated either in JAR cells exposed to hypoxia or in placentas of PE- and IUGR-complicated pregnancies, suggesting that hypoxia-dependent activation of NFAT5 serves as a separate function to its tonicity-dependent stimulation.
Conduction mechanism, impedance spectroscopic investigation and dielectric behavior of La0.5Ca0.5-xAgxMnO3 manganites with compositions below the concentration limit of silver solubility in perovskites (0 ≤ x ≤ 0.2).
Khirouni et al., Gabès, Tunisia. In Dalton Trans, Jul 2015
Experimental results are found to be in good agreement with the Smit and Wijn theory.
Spectrum of diverse genomic alterations define non-clear cell renal carcinoma subtypes.
Seshagiri et al., San Francisco, United States. In Nat Genet, 2015
We identified ten significantly mutated genes in pRCC, including MET, NF2, SLC5A3, PNKD and CPQ.
The rs9982601 polymorphism of the region between the SLC5A3/MRPS6 and KCNE2 genes associated with a prevalence of myocardial infarction and subsequent long-term mortality.
Kamiński et al., In Pol Arch Med Wewn, 2014
INTRODUCTION:  rs9982601 (C>T) is a polymorphism of the noncoding region between the SLC5A3/MRPS6 and KCNE2 genes.
Increased trophoblast expression of NFAT5/TonEBP in pre-eclamptic placentas and hyperosmolar-treated BeWo cells.
Arroyo et al., Kansas City, United States. In Eur J Obstet Gynecol Reprod Biol, 2014
OBJECTIVES: To assess the concentrations of inositol and sorbitol, and determine the expression of related osmolyte factors [nuclear factor of activated T cells 5, also known as tonicity responsive binding protein (NFAT5/TonEBP); sodium myo-inositol transporter (SLC5A3); and aldose reductase] in placentas of pre-eclamptic (PE) patients and trophoblast BeWo cells subjected to hypertonic stress in vitro.
A framework radiation hybrid map of buffalo chromosome 1 ordering scaffolds from buffalo genome sequence assembly.
Amaral-Trusty et al., Ribeirão Preto, Brazil. In Genet Mol Res, 2014
In this study, we constructed a new framework radiation hybrid (RH) map from BBU1 using BBURH5000 panel adding nine new genes (ADRB3, ATP2C1, COPB2, CRYGS, P2RY1, SLC5A3, SLC20A2, SST, and ZDHHC2) and one microsatellite (CSSM043) to the set of markers previously mapped on BBU1.
Hypotonic activation of the myo-inositol transporter SLC5A3 in HEK293 cells probed by cell volumetry, confocal and super-resolution microscopy.
Sukhorukov et al., Würzburg, Germany. In Plos One, 2014
The present study explores the SLC5A3 protein as a possible transporter of myo-inositol in hyponically swollen HEK293 cells.
Effect of ultraviolet A exposure on transport of compatible organic osmolytes in human lens epithelial cells.
Zhang et al., Shenyang, China. In Genet Mol Res, 2014
This osmolyte strategy requires the expression of specific osmolyte transporters such as betaine (BGT-1), myoinositol (SMIT), and taurine (TAUT).
Glucose transport families SLC5 and SLC50.
Wright, Los Angeles, United States. In Mol Aspects Med, 2013
However, the choline transporter CHT is encoded in by the 8 exon SLC5A7 gene and the myoinositol SMIT transporter by the 1 exon SLC5A3 gene.
Mus spicilegus endogenous retrovirus HEMV uses murine sodium-dependent myo-inositol transporter 1 as a receptor.
Coffin et al., Boston, United States. In J Virol, 2012
These findings add Mus spicilegus endogenous retrovirus HEMV as a second member to the murine leukemia virus subgroup that uses mSMIT1 to gain entry into cells.
Sodium/myo-inositol cotransporter 1 and myo-inositol are essential for osteogenesis and bone formation.
Kung et al., Hong Kong, Hong Kong. In J Bone Miner Res, 2011
Sodium/MI cotransporter 1 (SMIT1, the major cotransporter of MI) knockout (SMIT1(-/-)) mice with markedly reduced tissue myoinositol (MI) levels were used to characterize the essential roles of MI and SMIT1 in osteogenesis.
Sodium/myo-Inositol transporters: substrate transport requirements and regional brain expression in the TgCRND8 mouse model of amyloid pathology.
McLaurin et al., Toronto, Canada. In Plos One, 2010
brain SMIT1 levels were higher than SMIT2, however, regional differences were observed
Significance of SGK1 in the regulation of neuronal function.
Lang et al., Tübingen, Germany. In J Physiol, 2010
NHE3, NKCC2, NCC, NaPiIIb, SMIT, GLUT1,4, SGLT1, NaDC, EAAT1-5, SN1, ASCT2, 4F2/LAT, PepT2), and the Na(+)/K(+)-ATPase.
Genome-wide association of early-onset myocardial infarction with single nucleotide polymorphisms and copy number variants.
Altshuler et al., Boston, United States. In Nat Genet, 2009
SNPs at nine loci reached genome-wide significance: three are newly identified (21q22 near MRPS6-SLC5A3-KCNE2, 6p24 in PHACTR1 and 2q33 in WDR12) and six replicated prior observations (9p21, 1p13 near CELSR2-PSRC1-SORT1, 10q11 near CXCL12, 1q41 in MIA3, 19p13 near LDLR and 1p32 near PCSK9).
Human sodium/inositol cotransporter 2 (SMIT2) transports inositols but not glucose in L6 cells.
Ostlund et al., Saint Louis, United States. In Arch Biochem Biophys, 2009
Expression and/or function of SMIT2 may be reduced in diabetes mellitus, insulin resistance and polycystic ovary syndrome causing abnormal inositol meteabolism
Characterization of the null murine sodium/myo-inositol cotransporter 1 (Smit1 or Slc5a3) phenotype: myo-inositol rescue is independent of expression of its cognate mitochondrial ribosomal protein subunit 6 (Mrps6) gene and of phosphatidylinositol levels in neonatal brain.
Berry et al., Philadelphia, United States. In Mol Genet Metab, 2008
Mrps6 gene expression may not be contingent on function of Slc5a3 gene, while inositide deficiency may not be the cause of lethal apnea in null Slc5a3 mice.
Dealing with stable structures at ribosome binding sites: bacterial translation and ribosome standby.
Wagner et al., Uppsala, Sweden. In Rna Biol, 2007
de Smit and van Duin(1) proposed a "ribosome standby" model to theoretically solve this paradox: the 30S ribosome binds nonspecifically to an accessible site on the mRNA (standby site), waiting for a transient opening of a stable RBS hairpin.
Imbalance of glial-neuronal interaction in synapses: a possible mechanism of the pathophysiology of bipolar disorder.
Mitterauer, Salzburg, Austria. In Neuroscientist, 2004
Smit and coworkers proposed a model of a cholinergic tripartite synapse based on the identification of a glial-derived binding protein (BP) that is secreted into the synapse and binds free acetylcholine (ACh), thus reducing the levels of ACh available for stimulating the postsynapse.
Neurodevelopment and mood stabilizers.
Harwood, London, United Kingdom. In Curr Mol Med, 2003
All three mood stabilizers suppress inositol signaling, results further supported by studies on the enzyme prolyl oligopeptidase (PO) and the sodium myo-inositol transporter (SMIT).
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