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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Dec 2016.

Smg-8 homolog, nonsense mediated mRNA decay factor

Top mentioned proteins: LIP, SMG, caspase-3, UPF1, STEP
Papers on SMG-8
A network of SMG-8, SMG-9 and SMG-1 C-terminal insertion domain regulates UPF1 substrate recruitment and phosphorylation.
Schaffitzel et al., Grenoble, France. In Nucleic Acids Res, Oct 2015
Phosphorylation of the essential NMD effector UPF1 by the phosphoinositide-3-kinase-like kinase (PIKK) SMG-1 is a key step in NMD and occurs when SMG-1, its two regulatory factors SMG-8 and SMG-9, and UPF1 form a complex at a terminating ribosome.
Inhibition of SMG-8, a subunit of SMG-1 kinase, ameliorates nonsense-mediated mRNA decay-exacerbated mutant phenotypes without cytotoxicity.
Ohno et al., Minamata, Japan. In Proc Natl Acad Sci U S A, 2013
Of the 15 NMD factors tested, knockdown of SMG-8 produced the best effect for restoring defective mRNA and protein levels without affecting cell growth, cell-cycle progression, or endoplasmic reticulum stress.
Genetic characterization of smg-8 mutants reveals no role in C. elegans nonsense mediated decay.
Mango et al., Cambridge, United States. In Plos One, 2011
In mammals, SMG-8 has been implicated in the NMD pathway, in part by its association with SMG-1 kinase.
Role of a tyrosine phosphorylation of SMG-9 in binding of SMG-9 to IQGAP and the NMD complex.
Konishi et al., Shōbara, Japan. In Biochem Biophys Res Commun, 2011
SMG-9 is a component of the NMD complex, a heterotetramer that also includes SMG-1 and SMG-8 in the complex.
The nonsense-mediated mRNA decay SMG-1 kinase is regulated by large-scale conformational changes controlled by SMG-8.
Llorca et al., Madrid, Spain. In Genes Dev, 2011
large-scale conformational changes induced by SMG-8 after SMG-9-mediated recruitment tune SMG-1 kinase activity to modulate nonsense-mediated mRNA decay
Characterization of SMG-9, an essential component of the nonsense-mediated mRNA decay SMG1C complex.
Llorca et al., Madrid, Spain. In Nucleic Acids Res, 2011
SMG-9 is part of a protein kinase complex, SMG1C, which consists of the SMG-1 kinase, SMG-8 and SMG-9.
SMG-8 and SMG-9, two novel subunits of the SMG-1 complex, regulate remodeling of the mRNA surveillance complex during nonsense-mediated mRNA decay.
Ohno et al., Yokohama, Japan. In Genes Dev, 2009
We identified SMG-8 and SMG-9 as novel subunits of the SMG-1 complex.
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